Výsledky vyhledávání - "Thiazolidine 2 4 dione"

Synthesis, characterization, anticancer and in silico studies of a pyrazole-tethered thiazolidine-2,4-dione derivative

Autor: Ashanul Haque, Meher Rizvi, Khalaf M. Alenezi, Raoudha Soury, Md. Mushtque, Musherah M. Alshammari

Publikováno v: Journal of Biomolecular Structure and Dynamics. 40:13075-13082

A new pyrazole-tethered thiazolidine-2,4-dione derivative (8) has been synthesized by the Knoevenagel condensation of 3-(4-nitrophenyl)-1-phenyl-1H-pyrazole-4-carbaldehyde (4) and 3-(2,4-dioxothiazolidin-3-yl)propanenitrile (7). The structure of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::355f9977f831d730d9fe2c721f232832
https://doi.org/10.1080/07391102.2021.1981451

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Design and synthesis of a new tripod-chromogenic sensor based on a s-triazine and thiazolidine-2,4-dione ring (TCST) for naked-eye detection of Li+

Autor: Nosrat O. Mahmoodi, Hadiseh Yazdani Nyaki, Meysam Pasandideh Nadamani

Publikováno v: Canadian Journal of Chemistry. 99:482-490

A novel tripod-chromogenic sensor based on a s-triazine and thiazolidine-2,4-dione ring (TCST) was designed, synthesized, and applied as a colorimetric probe in aqueous solutions of dimethyl sulfoxide (DMSO). The probe showed a highly sensitive and s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::01011d1ca76d1e024093c2533437e31a
https://doi.org/10.1139/cjc-2020-0366

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De-novo design and synthesis of conformationally restricted thiazolidine-2,4-dione analogues: highly selective PPAR-γ agonist in search of anti-diabetic agent

Autor: Mala Parab, Santosh S. Chhajed, Pramodkumar P. Gupta, Jayprakash N. Sangshetti, Sanjay J. Kshirsagar, Debjani Dasgupta, Pooja E. Shinde

Publikováno v: Structural Chemistry. 31:1375-1385

In the present investigation, design, molecular docking simulations, and synthesis of few 2,4-thiazolidinedione for selective modulation of PPAR-gamma are reported. Further evaluation of anti-diabetic activity of few thiazolidine-2,4-diones is assess

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ad23381312d58a21d2712d2292292399
https://doi.org/10.1007/s11224-020-01500-4

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Concise perspectives on some synthetic thiazolidine-2,4-dione derivatives and their specific pharmacodynamic aspects

Autor: Rupak Kumar, Natália Cruz-Martins, Atul Kabra, Srinivasa Rao Vulichi, Kapur Suman, Chunduri Venkata Rao

Publikováno v: Life sciences. 271

Glitazones are synthetic derivatives of thiazolidinedione, and are designated as oral anti-diabetic agents, primarily acting on peroxisome proliferator-activated receptor-gamma (PPAR-γ) receptors and driving some crucial metabolic pathways linked to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ef1c2b9445c7ddfcd45208148d5367a
https://pubmed.ncbi.nlm.nih.gov/33577851

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Antitubercular properties of thiazolidin-4-ones - A review

Autor: Nazar Trotsko

Publikováno v: European journal of medicinal chemistry. 215

Thiazolidin-4-one scaffold has great potential for medicinal chemistry and is of interest to scientists in view of wide spectrum of biological activity. This scaffold is often used for designing of small molecules with various biological activity inc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cea0d7d00100b4ecc7df19a2008e806
https://pubmed.ncbi.nlm.nih.gov/33588179

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Design, synthesis, molecular docking, anticancer evaluations, and in silico pharmacokinetic studies of novel 5-[(4-chloro/2,4-dichloro)benzylidene]thiazolidine-2,4-dione derivatives as VEGFR-2 inhibitors

Autor: Khaled El-Adl, Rezk R. Ayyad, Mohamed Nasser, Hamada S. Abulkhair, Helmy Sakr, Hazem A. Mahdy, Sanadelaslam S. A. El‐Hddad, Abdel-Ghany A. El-Helby

Publikováno v: Archiv der PharmazieREFERENCES. 354(2)

The anticancer activity of novel thiazolidine-2,4-diones was evaluated against HepG2, HCT-116, and MCF-7 cells. MCF-7 was the most sensitive cell line to the cytotoxicity of the new derivatives. In particular, compounds 18, 12, 17, and 16 were found

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c2af2a5e3d142b366a022b3cfb99d8c
https://pubmed.ncbi.nlm.nih.gov/33073374

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