Zobrazeno 1 - 10 of 47 pro vyhledávání: '"Thiago Trovati Maciel"'
2
Akademický článek
Innate immune cells, major protagonists of sickle cell disease pathophysiology
Autor: Slimane Allali, Thiago Trovati Maciel, Olivier Hermine, Mariane de Montalembert
Publikováno v: Haematologica, Vol 105, Iss 2 (2020)
Sickle cell disease (SCD), considered the most common monogenic disease worldwide, is a severe hemoglobin disorder. Although the genetic and molecular bases have long been characterized, the pathophysiology remains incompletely elucidated and therape
Externí odkaz: https://doaj.org/article/92a6c406221341a7b2f8c81d304e469f
Zobrazit plný text záznamu
3
Akademický článek
Vitamin D Receptor Controls Cell Stemness in Acute Myeloid Leukemia and in Normal Bone Marrow
Autor: Etienne Paubelle, Florence Zylbersztejn, Thiago Trovati Maciel, Caroline Carvalho, Annalisa Mupo, Meyling Cheok, Liesbet Lieben, Pierre Sujobert, Justine Decroocq, Akihiko Yokoyama, Vahid Asnafi, Elizabeth Macintyre, Jérôme Tamburini, Valérie Bardet, Sylvie Castaigne, Claude Preudhomme, Hervé Dombret, Geert Carmeliet, Didier Bouscary, Yelena Z. Ginzburg, Hughes de Thé, Marc Benhamou, Renato C. Monteiro, George S. Vassiliou, Olivier Hermine, Ivan C. Moura
Publikováno v: Cell Reports, Vol 30, Iss 3, Pp 739-754.e4 (2020)
Summary: Vitamin D (VD) is a known differentiating agent, but the role of VD receptor (VDR) is still incompletely described in acute myeloid leukemia (AML), whose treatment is based mostly on antimitotic chemotherapy. Here, we present an unexpected r
Externí odkaz: https://doaj.org/article/53df66dd75014af1bb8489c5bd9cd832
Zobrazit plný text záznamu
4
Akademický článek
XPO1 regulates erythroid differentiation and is a new target for the treatment of β-thalassemia
Autor: Flavia Guillem, Michaël Dussiot, Elia Colin, Thunwarat Suriyun, Jean Benoit Arlet, Nicolas Goudin, Guillaume Marcion, Renaud Seigneuric, Sebastien Causse, Patrick Gonin, Marc Gastou, Marc Deloger, Julien Rossignol, Mathilde Lamarque, Zakia Belaid Choucair, Emilie Fleur Gautier, Sarah Ducamp, Julie Vandekerckhove, Ivan C. Moura, Thiago Trovati Maciel, Carmen Garrido, Xiuli An, Patrick Mayeux, Narla Mohandas, Geneviève Courtois, Olivier Hermine
Publikováno v: Haematologica, Vol 105, Iss 9 (2019)
β-thalassemia major (β-TM) is an inherited hemoglobinopathy caused by a quantitative defect in the synthesis of β-globin chains of hemoglobin, leading to the accumulation of free a-globin chains that aggregate and cause ineffective erythropoiesis.
Externí odkaz: https://doaj.org/article/9c8681ff1975469eabfa5bbd4e3b3606
Zobrazit plný text záznamu
5
Akademický článek
Lessons to Learn From Low-Dose Cyclosporin-A: A New Approach for Unexpected Clinical Applications
Autor: Camila Flores, Guillemette Fouquet, Ivan Cruz Moura, Thiago Trovati Maciel, Olivier Hermine
Publikováno v: Frontiers in Immunology, Vol 10 (2019)
Cyclosporin-A has been known and used for a long time, since its “fast track” approval in the early 80's. This molecule has rapidly demonstrated unexpected immunosuppressive properties, transforming the history of organ transplantation. Cyclospor
Externí odkaz: https://doaj.org/article/5db5500af8f347448bbb24c2bc090b4d
Zobrazit plný text záznamu
6
Akademický článek
Innate-like T cells in children with sickle cell disease.
Autor: Slimane Allali, Céline Dietrich, François Machavoine, Rachel Rignault-Bricard, Valentine Brousse, Mariane de Montalembert, Olivier Hermine, Thiago Trovati Maciel, Maria Leite-de-Moraes
Publikováno v: PLoS ONE, Vol 14, Iss 6, p e0219047 (2019)
BACKGROUND:The implication of lymphocytes in sickle cell disease pathogenesis is supported by a number of recent reports. These studies provided evidence for the activation of invariant natural killer T (iNKT) cells in adult patients, but did not inv
Externí odkaz: https://doaj.org/article/a2fff78dcc0d4b788d7f409f8e4b019c
Zobrazit plný text záznamu
9
IL-6 levels are dramatically high in the sputum from children with sickle cell disease during acute chest syndrome
Autor: Rachel Rignault-Bricard, Slimane Allali, Jean-Marc Talbot, Valentine Brousse, Florence Moulin, Olivier Hermine, Joséphine Brice, Melissa Taylor, Claire Heilbronner, Mariane de Montalembert, Thiago Trovati Maciel
Publikováno v: Blood Adv
Key Points Sputum interleukin-6 (IL-6) level is high during acute chest syndrome (ACS) in pediatric sickle cell disease, supporting anti–IL-6 trials. Sputum IL-8, CCL2, and CCL3 levels are also high during ACS, possibly contributing to recruitment
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b44dfbb9e2dea5666356a5fc5b0ef6a2
https://doi.org/10.1182/bloodadvances.2020003519
Zobrazit plný text záznamu
10
Mast cell-mediated inflammation relies on insulin-regulated aminopeptidase controlling cytokine export from the Golgi
Autor: Mirjana Weimershaus, Caroline Carvalho, Rachel Rignault, Emmanuelle Waeckel-Enee, Michael Dussiot, Peter van Endert, Thiago Trovati Maciel, Olivier Hermine
Publikováno v: Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology, 2023, pp.S0091-6749(23)00090-8. ⟨10.1016/j.jaci.2023.01.014⟩
International audience; Background: Upon activation, mast cells rapidly release preformed inflammatory mediators from large cytoplasmic granules via regulated exocytosis. This acute degranulation is followed by a late activation phase involving synth
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e84e82b8cef69a122a8ba44a67be530
https://doi.org/10.1101/2022.01.21.477149
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje