Cattle Tick Rhipicephalus microplus-Host Interface: A Review of Resistant and Susceptible Host Responses

Autor: Ala E. Tabor, Abid Ali, Gauhar Rehman, Gustavo Rocha Garcia, Amanda Fonseca Zangirolamo, Thiago Malardo, Nicholas N. Jonsson

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 7 (2017)

Ticks are able to transmit tick-borne infectious agents to vertebrate hosts which cause major constraints to public and livestock health. The costs associated with mortality, relapse, treatments, and decreased production yields are economically signi

Externí odkaz: https://doaj.org/article/396b7d0b3f7e40c398e1ea0efe88e0b1

B cells expressing IL-10 mRNA modulate memory T cells after DNA-Hsp65 immunization

Autor: R. L. L. Silva, Ademilson Panunto-Castelo, Célio Lopes Silva, Isabela C Fontoura, Arlete Aparecida Martins Coelho-Castelo, A. P. F. Trombone, W. Schluchting, Julio C. C. Lorenzi, Thiago Malardo, E. Padilha, Ana Flávia Gembre, Renata Ariza Marques Rossetti, J. E. C. Fiuza, L. R. Almeida

Publikováno v: Brazilian Journal of Medical and Biological Research v.48 n.12 2015
Brazilian Journal of Medical and Biological Research
Associação Brasileira de Divulgação Científica (ABDC)
instacron:ABDC
Brazilian Journal of Medical and Biological Research, Vol 48, Iss 12, Pp 1095-1100 (2015)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Brazilian Journal of Medical and Biological Research, Volume: 48, Issue: 12, Pages: 1095-1100, Published: 18 SEP 2015

In DNA vaccines, the gene of interest is cloned into a bacterial plasmid that is engineered to induce protein production for long periods in eukaryotic cells. Previous research has shown that the intramuscular immunization of BALB/c mice with a naked

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f1fb4b3dc0502c91f9704a5224c0d50
https://doi.org/10.1590/1414-431x20154409

Dissecting Tuberculosis Through Transcriptomic Studies

Autor: Célio Lopes Silva, Thiago Malardo, Rodrigo Ferracine Rodrigues, Wendy Martin Rios, Rogério Silva Rosada

Publikováno v: Transcriptomics in Health and Disease ISBN: 9783319119847

Tuberculosis (TB) remains one of the biggest treats in public health, infecting approximately one-third of the human population and killing almost two million people per year. Prophylaxis and treatment methods present some weakness, and HIV co-infect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::72176a1894a62182efe29738202ad649
https://doi.org/10.1007/978-3-319-11985-4_15

Intranasal vaccination with messenger RNA as a new approach in gene therapy: Use against tuberculosis

Autor: Isabela C Fontoura, Aristóbolo M. Silva, Carolina D. Rocha, Célio Lopes Silva, Ana Flávia Gembre, Ricardo L Lousada, Thiago Malardo, Renata Ariza Marques Rossetti, Ana Paula Favaro Trombone, Luciana P Almeida, Arlete Aparecida Martins Coelho-Castelo, Julio C. C. Lorenzi

Publikováno v: BMC Biotechnology
BMC Biotechnology, Vol 10, Iss 1, p 77 (2010)

Background mRNAs are highly versatile, non-toxic molecules that are easy to produce and store, which can allow transient protein expression in all cell types. The safety aspects of mRNA-based treatments in gene therapy make this molecule one of the m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ca70d57e4325b0605089e51b26e2a1a
https://doi.org/10.1186/1472-6750-10-77

B cells Can Modulate the CD8 Memory T Cell after DNA Vaccination Against Experimental Tuberculosis

Autor: A. P. F. Trombone, Ademilson P Castelo, Arlete Am Coelho-Castelo, Carolina D. Rocha, Célio Lopes Silva, Luciana P Almeida, Isabela C Fontoura, Ana Flávia Gembre, Ricardo Ll Silva, Julio C. C. Lorenzi, Thiago Malardo

Publikováno v: Genetic Vaccines and Therapy

Background Although B cells are important as antigen presenting cells (APC) during the immune response, their role in DNA vaccination models is unknown. Methods In this study in vitro and in vivo experiments were performed to evaluate the ability of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a9ca787fd7293c77cc873a03c0b075b