Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Thiago C. Genaro-Mattos"'
Autor:
Thiago C. Genaro-Mattos, Zeljka Korade, Namood-e Sahar, Jose Pedro Friedmann Angeli, Károly Mirnics, Eric S. Peeples
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Neonatal hypoxic-ischemic brain injury (HIBI) results in part from excess reactive oxygen species and iron-dependent lipid peroxidation (i.e. ferroptosis). The vitamin D precursor 7-dehydrocholesterol (7-DHC) may inhibit iron-dependent lipid
Externí odkaz:
https://doaj.org/article/663ea1161d9047ec88b4bd932d98b045
Publikováno v:
Journal of Lipid Research, Vol 63, Iss 8, Pp 100249- (2022)
Polypharmacy, or the simultaneous use of multiple drugs to treat a single patient, is a common practice in psychiatry. Unfortunately, data on the health effects of commonly used combinations of medications are very limited. In this study, we therefor
Externí odkaz:
https://doaj.org/article/0097b70b7532453c88d7285e8fbd493f
Autor:
Zeljka Korade, Luke B. Allen, Allison Anderson, Keri A. Tallman, Thiago C. Genaro-Mattos, Ned A. Porter, Karoly Mirnics
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Trazodone (TRZ) is a commonly prescribed antidepressant with significant off-label use for insomnia. A recent drug screening revealed that TRZ interferes with sterol biosynthesis, causing elevated levels of sterol precursor 7-dehydrocholeste
Externí odkaz:
https://doaj.org/article/67ed1de6baf7469e8270dfd73a93f59e
Publikováno v:
ACS Omega, Vol 6, Iss 8, Pp 5490-5498 (2021)
Externí odkaz:
https://doaj.org/article/8dea239fbc734c998cd7829b64523e9e
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 13, p 7420 (2022)
Ferroptosis is a type of programmed cell death caused by phospholipid peroxidation that has been implicated as a mechanism in several diseases resulting from ischemic-reperfusion injury. Most recently, ferroptosis has been identified as a possible ke
Externí odkaz:
https://doaj.org/article/bddc20986edd46c1afb01ce22b1d4859
Publikováno v:
Metabolites, Vol 12, Iss 5, p 467 (2022)
Hypoxic-ischemic brain injury (HIBI) leads to depletion of ATP, mitochondrial dysfunction, and enhanced oxidant formation. Measurement of acylcarnitines may provide insight into mitochondrial dysfunction. Plasma acylcarnitine levels are altered in ne
Externí odkaz:
https://doaj.org/article/21a7b54ab7394659a1ff8ca070665ee0
Autor:
Lucas S. Dantas, Adriano B. Chaves-Filho, Fernando R. Coelho, Thiago C. Genaro-Mattos, Keri A. Tallman, Ned A. Porter, Ohara Augusto, Sayuri Miyamoto
Publikováno v:
Redox Biology, Vol 19, Iss , Pp 105-115 (2018)
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by degeneration of upper and lower motor neurons. While the fundamental causes of the disease are still unclear, the accumulation of Cu,Zn-superoxide dismutase (SOD1) i
Externí odkaz:
https://doaj.org/article/eaaf64f788d74ebea9fb4310d3dfd13a
Autor:
Venugopal Gunda, Thiago C. Genaro-Mattos, Jyoti B. Kaushal, Ramakanth Chirravuri-Venkata, Gopalakrishnan Natarajan, Kavita Mallya, Paul M. Grandgenett, Karoly Mirnics, Surinder K. Batra, Zeljka Korade, Satyanarayana Rachagani
Publikováno v:
Metabolites, Vol 12, Iss 1, p 47 (2022)
Pancreatic cancer (PC) is characterized by metabolic deregulations that often manifest as deviations in metabolite levels and aberrations in their corresponding metabolic genes across the clinical specimens and preclinical PC models. Cholesterol is o
Externí odkaz:
https://doaj.org/article/59e26ebcfb55434f8d9198cdd707ce65
Autor:
Zeljka Korade, Thiago C. Genaro-Mattos, Keri A. Tallman, Wei Liu, Krassimira A. Garbett, Katalin Koczok, Istvan Balogh, Karoly Mirnics, Ned A. Porter
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 11, Pp 2139-2146 (2017)
Smith-Lemli-Opitz syndrome is a recessive disorder caused by mutations in 7-dehydrocholesterol reductase (DHCR)7 with a heterozygous (HET) carrier frequency of 1–3%. A defective DHCR7 causes accumulation of 7-dehydrocholesterol (DHC), which is a hi
Externí odkaz:
https://doaj.org/article/fa4381a31948402ab99163f966358465
Autor:
Chelsey McConnell, Melissa Thoene, Matthew Van Ormer, Jeremy D. Furtado, Zeljka Korade, Thiago C. Genaro-Mattos, Corrine Hanson, Ann Anderson-Berry
Publikováno v:
Antioxidants, Vol 10, Iss 9, p 1409 (2021)
Carotenoids are antioxidant nutrients with the potential to provide protection against oxidative stress. Plasma carotenoid concentrations are lower in newborn infants compared to their mothers; however, limited information is available regarding how
Externí odkaz:
https://doaj.org/article/1485f4855ba64e149afb045df22c0734