Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Thiago Arzua"'
Publikováno v:
Translational Psychiatry, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract Alcohol consumption during pregnancy can significantly impact the brain development of the fetus, leading to long-term cognitive and behavioral problems. However, the underlying mechanisms are not well understood. In this study, we investiga
Externí odkaz:
https://doaj.org/article/b10d38aa368c4e4e8762178753f33733
Autor:
Gihan S. Gunaratne, Robyn T. Rebbeck, Lindsey M. McGurran, Yasheng Yan, Thiago Arzua, Talia Frolkis, Daniel J. Sprague, Xiaowen Bai, Razvan L. Cornea, Timothy F. Walseth, Jonathan S. Marchant
Publikováno v:
iScience, Vol 25, Iss 1, Pp 103706- (2022)
Summary: Ryanodine receptors (RyRs) are large, intracellular ion channels that control Ca2+ release from the sarco/endoplasmic reticulum. Dysregulation of RyRs in skeletal muscle, heart, and brain has been implicated in various muscle pathologies, ar
Externí odkaz:
https://doaj.org/article/94f636ca50da4ffaa3d30ac7bc2841a5
Autor:
Yasheng Yan, Sarah Logan, Xiaojie Liu, Bixuan Chen, Congshan Jiang, Thiago Arzua, Ramani Ramchandran, Qing-song Liu, Xiaowen Bai
Publikováno v:
Cells, Vol 11, Iss 16, p 2497 (2022)
Emerging evidence from human epidemiologic and animal studies has demonstrated that developmental anesthesia neurotoxicity could cause long-term cognitive deficits and behavioral problems. However, the underlying mechanisms remain largely unknown. We
Externí odkaz:
https://doaj.org/article/2c74bd1492984ed6b0765a70a870a2b8
Publikováno v:
Cellular Physiology and Biochemistry, Vol 49, Iss 6, Pp 2496-2510 (2018)
Background: Propofol induces acute neurotoxicity (e.g., neuroapoptosis) followed by impairment of long-term memory and learning in animals. However, underlying mechanisms remain largely unknown. Long non-coding RNAs (lncRNAs) are found to participate
Externí odkaz:
https://doaj.org/article/9c8e3384c35d4062820a36760fcbb90e
Autor:
Thiago Arzua, Yasheng Yan, Congshan Jiang, Sarah Logan, Reilly L. Allison, Clive Wells, Suresh N. Kumar, Richard Schäfer, Xiaowen Bai
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-1 (2021)
A Correction to this paper has been published: https://doi.org/10.1038/s41398-021-01214-z.
Externí odkaz:
https://doaj.org/article/08071854a11c43ba97ebbe2b1ac37bcc
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 3, p 1389 (2021)
Sevoflurane, one of the most commonly used pediatric anesthetics, was found to cause developmental neurotoxicity. To understand specific risk groups and develop countermeasures, a better understanding of its mechanisms is needed. We hypothesize that,
Externí odkaz:
https://doaj.org/article/8c9568e4139745a78c3dea769847c3fc
Autor:
Sarah Logan, Thiago Arzua, Yasheng Yan, Congshan Jiang, Xiaojie Liu, Lai-Kang Yu, Qing-Song Liu, Xiaowen Bai
Publikováno v:
Cells, Vol 9, Iss 5, p 1301 (2020)
Background: The development of 3D cerebral organoid technology using human-induced pluripotent stem cells (iPSCs) provides a promising platform to study how brain diseases are appropriately modeled and treated. So far, understanding of the characteri
Externí odkaz:
https://doaj.org/article/257fd78aa4264e87b4d3a98220a78e95
Autor:
Francie Moehring, Ashley M Cowie, Anthony D Menzel, Andy D Weyer, Michael Grzybowski, Thiago Arzua, Aron M Geurts, Oleg Palygin, Cheryl L Stucky
Publikováno v:
eLife, Vol 7 (2018)
The first point of our body’s contact with tactile stimuli (innocuous and noxious) is the epidermis, the outermost layer of skin that is largely composed of keratinocytes. Here, we sought to define the role that keratinocytes play in touch sensatio
Externí odkaz:
https://doaj.org/article/9c7dcf58ac494d61a51cc38ddb4ec57e
Autor:
Yasheng Yan, Shigang Qiao, Chika Kikuchi, Ivan Zaja, Sarah Logan, Congshan Jiang, Thiago Arzua, Xiaowen Bai
Publikováno v:
Brain Sciences, Vol 7, Iss 10, p 130 (2017)
It has been shown that propofol can induce widespread apoptosis in neonatal mouse brains followed by long-term cognitive dysfunction. However, selective brain area and cell vulnerability to propofol remains unknown. This study was aimed to dissect to
Externí odkaz:
https://doaj.org/article/ffc99dc5561047aaa94729f9e34e9c6e
Publikováno v:
Neurosci Biobehav Rev
Brain development is a dynamic and lengthy process that includes cell proliferation, migration, neurogenesis, gliogenesis, synaptogenesis, and pruning. Disruption of any of these developmental events can result in long-term outcomes ranging from brai