Zobrazeno 1 - 10
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pro vyhledávání: '"Thi Nhu Quynh Phan"'
Akademický článek
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Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 151:1-8
Aim The study was aimed to investigate the impact of superassociation of hydrophobic ion pairs (HIPs) on membrane permeability. Methods Toluidine blue O (TBO) as a cationic model compound was complexed with anionic counter ions having different physi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b6a9e682adc3b4b13635b7c6d39a66f
https://doi.org/10.1016/j.ejpb.2020.03.016
https://doi.org/10.1016/j.ejpb.2020.03.016
Autor:
Barbara Matuszczak, Aida Dizdarević, Andreas Bernkop-Schnürch, Thi Nhu Quynh Phan, Nuri Ari Efiana
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 142:92-100
Hypothesis Because of its hydrophilic character the peptide drug Polymyxin B (PMB) cannot be incorporated in lipophilic nanocarrier systems such as self-emulsifying drug delivery systems (SEDDS) for oral administration. Due to the formation of imine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9069d40d44686682b31905fd8b2070ba
https://doi.org/10.1016/j.ejpb.2019.06.002
https://doi.org/10.1016/j.ejpb.2019.06.002
Publikováno v:
Journal of Controlled Release. 304:146-155
Membrane permeability of charged BCS class 3 drugs can be tremendously improved by the formation of hydrophobic ion-pairs (HIPs), as the lipophilic character of the drug is strongly improved so that it can move across the phospholipid bilayer of epit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b7661f51292d963e1e7b519ad42840e
https://doi.org/10.1016/j.jconrel.2019.05.011
https://doi.org/10.1016/j.jconrel.2019.05.011
Autor:
Andreas Bernkop-Schnürch, Flavia Laffleur, Thi Nhu Quynh Phan, Sergey Zaichik, Bao Le-Vinh, Ruba Ismail
Publikováno v:
ACS biomaterials scienceengineering. 6(9)
The aim of this study was to evaluate the potential of n-octadecyl sulfate (SOS) as a counterion for hydrophobic ion pairing (HIP) with exenatide—a potent glucagon-like peptide-1 (GLP-1) analogue i...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::956813319a4d0377f7611858a7f2ec06
https://pubmed.ncbi.nlm.nih.gov/33455296
https://pubmed.ncbi.nlm.nih.gov/33455296
Akademický článek
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Publikováno v:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 162
Aim The aim of this study was to form hydrophobic ion-pairs of proteinase with cationic surfactants and to incorporate them into self-emulsifying drug delivery systems (SEDDS) to improve their mucus permeating properties. Methods Proteinase was ion-p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fa6151dc2659553b369cccc03805411
https://pubmed.ncbi.nlm.nih.gov/33271277
https://pubmed.ncbi.nlm.nih.gov/33271277
Publikováno v:
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 152
The lipophilic character of peptides can be tremendously improved by hydrophobic ion pairing (HIP) with counterions to be efficiently incorporated into lipid-based nanocarriers (NCs). Herein, HIPs of exenatide with the cationic surfactant tetraheptyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f77f0300c0c4eb69146b6076c9d5789
https://pubmed.ncbi.nlm.nih.gov/32371152
https://pubmed.ncbi.nlm.nih.gov/32371152
Publikováno v:
Colloids and Surfaces B: Biointerfaces. 161:228-235
This study aimed to improve the mucus permeating properties of self-emulsifying drug delivery systems (SEDDS) by anchoring lipidized bromelain, papain and trypsin using palmitoyl chloride. SEDDS containing enzyme-palmitate conjugates were characteriz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72fa9cf5c5fcc8b6a4fbe10132fd3577
https://doi.org/10.1016/j.colsurfb.2017.10.032
https://doi.org/10.1016/j.colsurfb.2017.10.032
Akademický článek
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