Výsledky vyhledávání - "Thi My Anh Neildez"

Akademický článek

Stochastic fluctuations and distributed control of gene expression impact cellular memory.

Autor: Guillaume Corre, Daniel Stockholm, Ophélie Arnaud, Gaël Kaneko, José Viñuelas, Yoshiaki Yamagata, Thi My Anh Neildez-Nguyen, Jean-Jacques Kupiec, Guillaume Beslon, Olivier Gandrillon, András Paldi

Publikováno v: PLoS ONE, Vol 9, Iss 12, p e115574 (2014)

Despite the stochastic noise that characterizes all cellular processes the cells are able to maintain and transmit to their daughter cells the stable level of gene expression. In order to better understand this phenomenon, we investigated the tempora

Externí odkaz: https://doaj.org/article/07a7d8a2887c4d85b9cfc1bf069cba8e

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Akademický článek

Bistable cell fate specification as a result of stochastic fluctuations and collective spatial cell behaviour.

Autor: Daniel Stockholm, Frédérique Edom-Vovard, Sophie Coutant, Peggy Sanatine, Yoshiaki Yamagata, Guillaume Corre, Laurent Le Guillou, Thi My Anh Neildez-Nguyen, Andràs Pàldi

Publikováno v: PLoS ONE, Vol 5, Iss 12, p e14441 (2010)

BACKGROUND: In culture, isogenic mammalian cells typically display enduring phenotypic heterogeneity that arises from fluctuations of gene expression and other intracellular processes. This diversity is not just simple noise but has biological releva

Externí odkaz: https://doaj.org/article/ce338b04a5e345839f26ad4545577deb

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Akademický článek

The origin of phenotypic heterogeneity in a clonal cell population in vitro.

Autor: Daniel Stockholm, Rachid Benchaouir, Julien Picot, Philippe Rameau, Thi My Anh Neildez, Gabriel Landini, Corinne Laplace-Builhé, Andras Paldi

Publikováno v: PLoS ONE, Vol 2, Iss 4, p e394 (2007)

BACKGROUND: The spontaneous emergence of phenotypic heterogeneity in clonal populations of mammalian cells in vitro is a rule rather than an exception. We consider two simple, mutually non-exclusive models that explain the generation of diverse cell

Externí odkaz: https://doaj.org/article/a83aec74cadd41a0a6170c656ec1e2cc

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Temporary Reduction of Membrane CD4 with the Antioxidant MnTBAP Is Sufficient to Prevent Immune Responses Induced by Gene Transfer

Autor: Thi My Anh Neildez-Nguyen, Fanny Onodi, Sylvie Da Rocha, Jérôme Poupiot, David Fenard, J.L. Bigot, Guillaume Corre, Jérémie Cosette, Anne Galy, Bernard Gjata

Publikováno v: Mol Ther Methods Clin Dev
Mol Ther Methods Clin Dev, 2019, 14, pp.285-299. ⟨10.1016/j.omtm.2019.06.011⟩
Molecular Therapy. Methods & Clinical Development
Molecular Therapy-Methods and Clinical Development
Molecular Therapy-Methods and Clinical Development, 2019, pp.285-299. ⟨10.1016/j.omtm.2019.06.011⟩

International audience; Unexpectedly, the synthetic antioxidant MnTBAP was found to cause a rapid and reversible downregulation of CD4 on T cells in vitro and in vivo. This effect resulted from the internalization of membrane CD4 T cell molecules int

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4902724e7f741823e6835b6214e49ac
https://hal.archives-ouvertes.fr/hal-02880792

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Epigenetic gene expression noise and phenotypic diversification of clonal cell populations

Autor: Andras Paldi, Corinne Laplace, Thi My Anh Neildez-Nguyen, Céline Vignal, Christine Le Bec, Julien Picot, Valérie Allo, Philippe Rameau, Aurélie Parisot, Daniel Stockholm

Publikováno v: Differentiation. 76:33-40

Spontaneous emergence of phenotypic heterogeneity in cultures of genetically identical cells is a frequently observed phenomenon that provides a simple in vitro experimental system to model the problems of in vivo differentiation. In the present stud

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dd77d90e8c23cb253b6fce53797247f
https://doi.org/10.1111/j.1432-0436.2007.00219.x

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Hypoxic culture conditions enhance the generation of regulatory T cells

Autor: Thi My Anh Neildez-Nguyen, Guillaume Corre, Sylvie Da Rocha, Florence Boisgerault, Andras Paldi, J.L. Bigot, Anne Galy

Publikováno v: Immunology
Immunology, Wiley, 2015, 144 (3), pp.431-443. ⟨10.1111/imm.12388⟩
Immunology, 2015, 144 (3), pp.431-443. ⟨10.1111/imm.12388⟩

Summary The generation of large amounts of induced CD4+ CD25+ Foxp3+ regulatory T (iTreg) cells is of great interest for several immunotherapy applications, therefore a better understanding of signals controlling iTreg cell differentiation and expans

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3765c2d705ffd95a68ed5148a7da3f4
https://hal-univ-evry.archives-ouvertes.fr/hal-02178266

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Single Cell Dynamics Causes Pareto-Like Effect in Stimulated T Cell Populations

Autor: Thi My Anh Neildez-Nguyen, Jérémie Cosette, Alice Moussy, Fanny Onodi, Daniel Stockholm, Adrien Auffret-Cariou, Andras Paldi

Publikováno v: Scientific Reports
Scientific Reports, Nature Publishing Group, 2015, 5, pp.17756. ⟨10.1038/srep17756⟩
Scientific Reports, 2015, 5, pp.17756. ⟨10.1038/srep17756⟩

Cell fate choice during the process of differentiation may obey to deterministic or stochastic rules. In order to discriminate between these two strategies we used time-lapse microscopy of individual murine CD4 + T cells that allows investigating the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2ecb96957b12fb5dc6648f197e36de0
https://hal.archives-ouvertes.fr/hal-02880977

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Stochastic Fluctuations and Distributed Control of Gene Expression Impact Cellular Memory

Autor: Yoshiaki Yamagata, Ophélie Arnaud, José Viñuelas, Thi My Anh Neildez-Nguyen, Guillaume Corre, Guillaume Beslon, Gaël Kaneko, Jean-Jacques Kupiec, Daniel Stockholm, Andras Paldi, Olivier Gandrillon

Publikováno v: PLoS ONE
PLoS ONE, Public Library of Science, 2014, 9 (12), pp.e115574. ⟨10.1371/journal.pone.0115574⟩
PLoS ONE, Vol 9, Iss 12, p e115574 (2014)
PLoS ONE, 2014, 9 (12), pp.e115574. ⟨10.1371/journal.pone.0115574⟩

International audience; Despite the stochastic noise that characterizes all cellular processes the cells are able to maintain and transmit to their daughter cells the stable level of gene expression. In order to better understand this phenomenon, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3da9c785fdc063e9ca288d7feeb345dd
https://hal.archives-ouvertes.fr/hal-01370311/file/PlosOne.pdf

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