Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Thi M-D Nguyen"'
Autor:
Jordan D Lewicky, Alexandrine L Martel, Nya L Fraleigh, Amanda Boraman, Thi M-D Nguyen, Peter W Schiller, Tze Chieh Shiao, René Roy, Hoang-Thanh Le
Publikováno v:
PLoS ONE, Vol 13, Iss 9, p e0204472 (2018)
The therapeutic application of peptide-based drugs is significantly limited by the rapid proteolytic degradation that occurs when in blood. Encapsulation of these peptide structures within a delivery system, such as liposomes, can greatly improve bot
Externí odkaz:
https://doaj.org/article/84e1b41a2ce54f7cad73c25d5a19d4af
Autor:
Anh D. Lê, Alexandrine L. Martel, Leila Mousavifar, Jordan D. Lewicky, Hoang-Thanh Le, Thi M.-D. Nguyen, René Roy, Douglas Funk, Nya L. Fraleigh, Peter W. Schiller
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 15
International Journal of Molecular Sciences, Vol 22, Iss 7996, p 7996 (2021)
Volume 22
Issue 15
International Journal of Molecular Sciences, Vol 22, Iss 7996, p 7996 (2021)
Peptide therapeutics offer numerous advantages in the treatment of diseases and disorders of the central nervous system (CNS). However, they are not without limitations, especially in terms of their pharmacokinetics where their metabolic lability and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c96bed9f96be01a94d61a9d016a901c6
Autor:
Shigeki Yamaguchi, Thi M.-D. Nguyen, Lena Libertad Huerta-Esquivel, Peter W. Schiller, Tony L. Yaksh, Kelly A. Eddinger, Shinichi Kokubu
Publikováno v:
Scandinavian Journal of Pain. 19:193-206
Background and aims We systematically characterized the potency and side effect profile of a series of small opioid peptides with high affinity for the mu opioid receptor. Methods Male Sprague Dawley rats were prepared with intrathecal (IT) catheters
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8401756182d00e628eb870bd8a947546
https://doi.org/10.1515/sjpain-2018-0120
https://doi.org/10.1515/sjpain-2018-0120
Akademický článek
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Autor:
Jordan D. Lewicky, Thi M.-D. Nguyen, Tze Chieh Shiao, Amanda Boraman, René Roy, Peter W. Schiller, Nya L. Fraleigh, Hoang-Thanh Le, Sabine Montaut, Alexandrine L. Martel
Publikováno v:
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 154
Dynantin is a potent and selective synthetic polypeptide kappa opioid receptor antagonist which has potential antidepressant and anxiolytic-like therapeutic applications, however its clinical development has been hampered by plasma stability issues a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4bcb04819e3e29bb57aa3fa2c4adb2c
https://pubmed.ncbi.nlm.nih.gov/32717389
https://pubmed.ncbi.nlm.nih.gov/32717389
Publikováno v:
Pain Practice
Introduction Epidural infusion of local anesthetics with opioids is widely used for pain control during the perioperative-and peripartum-periods. Selection of the opioid, appropriate dosing, and follow-up by the acute pain service are critical in pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa0b4deff417f1592e92885410963d7f
http://hdl.handle.net/1887/120893
http://hdl.handle.net/1887/120893
Autor:
Peter W. Schiller, Jolanta Gutkowska, Carolane Blais, Thi M.-D. Nguyen, Julie L. Lavoie, Paul Tan
Publikováno v:
Obesity. 24:1946-1954
Objective Administration of the handle region peptide (HRP), a (pro)renin receptor blocker, decreases body weight gain and visceral adipose tissue (VAT) in high-fat/high-carbohydrate (HF/HC) diet-fed mice. The objective of this study was to elucidate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c2d957c02c411ac29916a9b0b37c7ff
https://doi.org/10.1002/oby.21592
https://doi.org/10.1002/oby.21592
Autor:
Tze Chieh Shiao, Nya L. Fraleigh, Jordan D. Lewicky, René Roy, Hoang-Thanh Le, Alexandrine L. Martel, Peter W. Schiller, Thi M.-D. Nguyen, Amanda Boraman
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 9, p e0204472 (2018)
PLoS ONE, Vol 13, Iss 9, p e0204472 (2018)
The therapeutic application of peptide-based drugs is significantly limited by the rapid proteolytic degradation that occurs when in blood. Encapsulation of these peptide structures within a delivery system, such as liposomes, can greatly improve bot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c28f8bd2c181f1796c32b69e0208c8a7
http://europepmc.org/articles/PMC6160049
http://europepmc.org/articles/PMC6160049
Autor:
Annie Wing Hoi Poon, Terence J. Coderre, Thi M.-D. Nguyen, Peter W. Schiller, André Laferrière, Amy Saray
Publikováno v:
ACS Chemical Neuroscience. 6:1789-1793
Reactive oxygen species (ROS) play an important role in the development of complex regional pain syndrome-Type I (CRPS-I), as also demonstrated with the chronic post ischemia pain (CPIP) animal model of CRPS-I. We show that morphine and the antioxida
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19c3b32739eb5fe400839dfe25176731
https://doi.org/10.1021/acschemneuro.5b00228
https://doi.org/10.1021/acschemneuro.5b00228
Autor:
Paul Tan, Catherine Michel, Thi M.-D. Nguyen, Peter W. Schiller, Rémi Rabasa-Lhoret, Sandra Bisotto, Julie L. Lavoie, Zulaykho Shamansurova, Jolanta Gutkowska, Marie-Soleil Gauthier
Publikováno v:
Obesity. 22:2201-2209
Objective Obesity is a worldwide epidemic and current treatments have limited success thus, novel therapies are warranted. Our objective was to determine whether the prorenin/renin receptor [(P)RR] is implicated in obesity. Methods Mice received a no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eef73c7bdfb16c486c51eb73295d73bf
https://doi.org/10.1002/oby.20844
https://doi.org/10.1002/oby.20844