LETC inhibits α-Syn aggregation and ameliorates motor deficiencies in the L62 mouse model of synucleinopathy.

Autor: Schwab K; School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK; Institute of Pharmacology, Charité - Universitätsmedizin Berlin, Hessische Str. 3-4, 10115, Berlin, Germany. Electronic address: karima.schwab@abdn.ac.uk., Frahm S; Institute of Pharmacology, Charité - Universitätsmedizin Berlin, Hessische Str. 3-4, 10115, Berlin, Germany., Magbagbeolu M; Institute of Pharmacology, Charité - Universitätsmedizin Berlin, Hessische Str. 3-4, 10115, Berlin, Germany., Horsley D; School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK., Goatman EA; School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK., Melis V; School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK., Theuring F; Institute of Pharmacology, Charité - Universitätsmedizin Berlin, Hessische Str. 3-4, 10115, Berlin, Germany., Ishaq A; Department of Chemistry, University of Aberdeen, Aberdeen, UK., Storey JMD; Department of Chemistry, University of Aberdeen, Aberdeen, UK; TauRx Therapeutics Ltd., 395 King Street, Aberdeen, AB24 5RP, UK., Harrington CR; School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK; TauRx Therapeutics Ltd., 395 King Street, Aberdeen, AB24 5RP, UK., Wischik CM; School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK; TauRx Therapeutics Ltd., 395 King Street, Aberdeen, AB24 5RP, UK., Riedel G; School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK.

Publikováno v: European journal of pharmacology [Eur J Pharmacol] 2024 May 05; Vol. 970, pp. 176505. Date of Electronic Publication: 2024 Mar 18.

Transient overexpression of the 5-HT 1A receptor impairs water-maze but not hole-board performance

Autor: Bert, B., Dere, E., Wilhelmi, N., Kusserow, H., Theuring, F., Huston, J.P., Fink, H.

Publikováno v: In Neurobiology of Learning and Memory 2005 84(1):57-68

Proteomic Analysis of Hydromethylthionine in the Line 66 Model of Frontotemporal Dementia Demonstrates Actions on Tau-Dependent and Tau-Independent Networks.

Autor: Schwab K; School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK.; Charité-Universitätsmedizin Berlin, Hessische Str. 3-4, 10115 Berlin, Germany., Melis V; School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK., Harrington CR; School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK.; TauRx Therapeutics Ltd., 395 King Street, Aberdeen AB24 5RP, UK., Wischik CM; School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK.; TauRx Therapeutics Ltd., 395 King Street, Aberdeen AB24 5RP, UK., Magbagbeolu M; Charité-Universitätsmedizin Berlin, Hessische Str. 3-4, 10115 Berlin, Germany., Theuring F; Charité-Universitätsmedizin Berlin, Hessische Str. 3-4, 10115 Berlin, Germany., Riedel G; School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK.

Publikováno v: Cells [Cells] 2021 Aug 22; Vol. 10 (8). Date of Electronic Publication: 2021 Aug 22.

Cu, Fe, and Zn isotope ratios in murine Alzheimer's disease models suggest specific signatures of amyloidogenesis and tauopathy.

Autor: Solovyev N; Department of Chemistry, Atomic & Mass Spectrometry-A&MS Research Unit, Ghent University, Ghent, Belgium., El-Khatib AH; BAM Bundesanstalt für Materialforschung und -prüfung, Division 1.1 Inorganic Trace Analysis, Berlin, Germany; Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, African Union Authority St, Abbassia, Ain Shams University, Cairo, Egypt., Costas-Rodríguez M; Department of Chemistry, Atomic & Mass Spectrometry-A&MS Research Unit, Ghent University, Ghent, Belgium., Schwab K; Institute of Medical Sciences, School of Medicine, Medical Sciences & Nutrition, Foresterhill, University of Aberdeen, Aberdeen, Scotland, United Kingdom., Griffin E; Trace Element Speciation Laboratory (TESLA), Department of Chemistry, University of Aberdeen, Aberdeen, Scotland, United Kingdom., Raab A; Trace Element Speciation Laboratory (TESLA), Department of Chemistry, University of Aberdeen, Aberdeen, Scotland, United Kingdom; Institute of Chemistry, Environmental Analytical Chemistry, University of Graz, Graz, Austria., Platt B; Institute of Medical Sciences, School of Medicine, Medical Sciences & Nutrition, Foresterhill, University of Aberdeen, Aberdeen, Scotland, United Kingdom., Theuring F; Charité - Universitätsmedizin Berlin, Institute of Pharmacology, Berlin, Germany., Vogl J; BAM Bundesanstalt für Materialforschung und -prüfung, Division 1.1 Inorganic Trace Analysis, Berlin, Germany., Vanhaecke F; Department of Chemistry, Atomic & Mass Spectrometry-A&MS Research Unit, Ghent University, Ghent, Belgium. Electronic address: frank.vanhaecke@ugent.be.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2021 Jan-Jun; Vol. 296, pp. 100292. Date of Electronic Publication: 2021 Jan 14.

Cholinergic and inflammatory phenotypes in transgenic tau mouse models of Alzheimer's disease and frontotemporal lobar degeneration.

Autor: Cranston AL; School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK., Wysocka A; Nencki Institute of Experimental Biology, Polish Academy of Science, Warsaw 02-093, Poland., Steczkowska M; Mossakowski Medical Research Centre, Warsaw 02-106, Poland., Zadrożny M; Mossakowski Medical Research Centre, Warsaw 02-106, Poland., Palasz E; Mossakowski Medical Research Centre, Warsaw 02-106, Poland., Harrington CR; School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK.; TauRx Therapeutics Ltd, Foresterhill, Aberdeen AB25 2ZP, UK., Theuring F; Institute of Pharmacology, Charite-Universitätsmedizin Berlin, Berlin, Germany., Wischik CM; School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK.; TauRx Therapeutics Ltd, Aberdeen AB24 5RP, UK., Riedel G; School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK., Niewiadomska G; Nencki Institute of Experimental Biology, Polish Academy of Science, Warsaw 02-093, Poland.

Publikováno v: Brain communications [Brain Commun] 2020 Mar 30; Vol. 2 (1), pp. fcaa033. Date of Electronic Publication: 2020 Mar 30 (Print Publication: 2020).