Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Thet Thet, Lin"'
Autor:
Saman Hewamana, Prasanna Gunasena, Chathuri Jayasinghe, Thurairajah Skandarajah, Mahesh Harischandra, Sobitha Abeyaratne, Lalith Ekanayake, Gnani Somasundaram, Surjit Somiah, Vadivelu Srinivasan, Gehan Arseculeratne, Neomal Perera, Jayaindra Fernando, Mazhar Faiz, Nihal Munasinghe, Ashfaq Mowlana, Samadhi Deshapriya, Supun Mawathakubura, Chandana Wickramarathna, Ananda Wijewickrama, Priyankara Jayawardena, Eranga Perera, Natasha Peiris, Sarath Paranawithane, Chitranganie Perera, Chitranga Kariyawasam, Sanjeewa Munasinghe, Chandu De Silva, Rohini Wadanamby, Geethani Galagoda, Thet Thet Lin, Bandula Wijesiriwardena, Jayantha Balawardena
Publikováno v:
JCO Global Oncology, Vol , Iss 8 (2022)
PURPOSEThere is a significant disparity in global cancer care and outcome between countries. Progress in the treatment of symptomatic plasma cell myeloma (PCM) in high-income countries is not seen in low- and middle-income countries.MATERIALS AND MET
Externí odkaz:
https://doaj.org/article/d2a2e4d692fd457c9b37139aee2222e7
Autor:
Saman Hewamana, Thurairajah Skandarajah, Chathuri Jayasinghe, Samadhi Deshapriya, Dhananjani Senarathna, Gehan Arseculeratne, Mahesh Harischandra, Gnani Somasundaram, Vadivelu Srinivasan, Surjit Somiah, Nihal Munasinghe, Sangeetha Hewawasam, Lalith Ekanayake, Rohini Wadanamby, Geethani Galagoda, Thet Thet Lin, Jayantha Balawardena
Publikováno v:
PLoS ONE, Vol 16, Iss 9, p e0256941 (2021)
BackgroundThe Covid-19 pandemic has caused significant morbidity and mortality among patients with cancer. Most countries employed measures to prevent spread of Covid-19 infection which include shielding, quarantine, lockdown, travel restrictions, ph
Externí odkaz:
https://doaj.org/article/d6f9931c63e64d2db0a98cd4194d5ba9
Autor:
Philip W. Howard, David E. Thurston, Christopher Fegan, Thet Thet Lin, Christopher Pepper, Janet M. Hartley, Arnaud C. Tiberghien, Luke A. Masterson, Stephen J. Gregson, Zhizhi Chen, Marie Suggitt, Christopher R.H. Martin, Marissa Coffils, Anzu Hamaguchi, John A. Hartley
Supplementary Data from SG2285, a Novel C2-Aryl-Substituted Pyrrolobenzodiazepine Dimer Prodrug That Cross-links DNA and Exerts Highly Potent Antitumor Activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25e04552841910414789329b4ff8923b
https://doi.org/10.1158/0008-5472.22384716
https://doi.org/10.1158/0008-5472.22384716
Genetic modification of primary chronic lymphocytic leukemia cells with a lentivirus expressing CD38
Autor:
Laurence Pearce, Liam Morgan, Thet Thet Lin, Saman Hewamana, R. James Matthews, Silvia Deaglio, Clare Rowntree, Christopher Fegan, Christopher Pepper, Paul Brennan
Publikováno v:
Haematologica, Vol 95, Iss 3 (2010)
Studies of the role of individual genes in chronic lymphocytic leukemia (CLL) have been hampered by the inability to consistently transfect primary tumor cells. Here, we describe a highly efficient method of genetically modifying primary CLL cells us
Externí odkaz:
https://doaj.org/article/923386e9dc694e1189be4f191b896955
Autor:
Tatjana Stankovic, Christopher Fegan, David G. Oscier, Kevin Norris, JC Strefford, Chris Pepper, D. Gonzalez de Castro, Monica Else, Matthew J. J. Rose-Zerilli, Nicole H. Heppel, Duncan M. Baird, Anne Gardiner, Zadie A. Davies, Thet Thet Lin, Andrew J. Steele, Helen Parker, Jade Forster, A. Parker, Latha Kadalayil, Andrew Collins, Daniel Catovsky
Publikováno v:
Leukemia
Telomere erosion and fusion play an important role in the pathology of many common human malignancies including CLL.1,2 Previous studies in CLL have shown that short telomeres defined on the basis of the median value or receiver operating characteris
Autor:
Chris Pepper, Rhiannon E. Jones, James R. Bailey, Duncan Matrin Baird, David Allsup, Kevin Norris, Guy Pratt, Christopher Fegan, Julia W. Grimstead, James M. Allan, Lynn Cawkwell, Bethan Britt-Compton, Nicole H. Heppel, Thet Thet Lin, Robert Kerrin Hills
Publikováno v:
British Journal of Haematology. 167:214-223
Defining the prognosis of individual cancer sufferers remains a significant clinical challenge. Here we assessed the ability of high-resolution single telomere length analysis (STELA), combined with an experimentally derived definition of telomere dy
Autor:
Chris Pepper, Thet Thet Lin, Robert Kerrin Hills, Renata Walewska, Martin J. S. Dyer, Aneela Majid, Guy Pratt, Zadie Davis, David Oscier, Simon D. Wagner, Ian Tracy, Stefan Gesk, Saman Hewamana, Paul Brennan, Anne Gardiner, Reiner Siebert, Christopher Fegan, Fiona Miall, Ben Kennedy
Publikováno v:
British Journal of Haematology. 156:499-507
Approximately 70% of chronic lymphocytic leukaemia (CLL) patients present with early stage disease, therefore defining which patients will progress and require treatment is a major clinical challenge. Here, we present the largest study of prognostic
Autor:
J. G. Mahdi, Paul Brennan, Christopher Fegan, Liam David Morgan, Saman Hewamana, Elisabeth Jane Walsby, Andrea G. S. Buggins, Eamon J. Mahdi, Chris Pepper, Thet Thet Lin, Laurence Pearce, Ivor D. Bowen, A. Al-Haza'a, Ali J. Mahdi
Publikováno v:
Cell Proliferation. 44:380-390
Objectives: Non-steroidal anti-inflammatory drugs have been shown to induce apoptosis in primary B-cell chronic lymphocytic leukaemia (CLL) cells, but the molecular mechanisms that underpin this observation have not been fully elucidated. Here, we ha
Autor:
Rhiannon E. Jones, Christopher Fegan, Saman Hewamana, Duncan M. Baird, Thet Thet Lin, Guy Pratt, Chris Pepper, Boitelo T. Letsolo, Jan Rowson
Publikováno v:
Blood. 116:1899-1907
We performed single-molecule telomere length and telomere fusion analysis in patients at different stages of chronic lymphocytic leukemia (CLL). Our work identified the shortest telomeres ever recorded in primary human tissue, reinforcing the concept
Autor:
Stephen J. Gregson, Thet Thet Lin, David E. Thurston, Christopher R. H. Martin, Philip W. Howard, Marissa Coffils, Christopher Fegan, Luke Masterson, Chris Pepper, Arnaud C. Tiberghien, Zhizhi Chen, Anzu Hamaguchi, John A. Hartley, Marie Suggitt, Janet M. Hartley
Publikováno v:
Cancer Research. 70:6849-6858
The pyrrolobenzodiazepines (PBD) are naturally occurring antitumor antibiotics, and a PBD dimer (SJG-136, SG2000) is in phase II trials. Many potent PBDs contain a C2-endo-exo unsaturated motif associated with the pyrrolo C-ring. The novel compound S