Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Theron M, Wall"'
Autor:
Paul L. Ornstein, David S. Bredt, Vanessa N. Barth, Eric S. Nisenbaum, Kar-Chan Choong, Wenhong Guo, Warren J. Porter, Kevin Matthew Gardinier, Emanuele Sher, Yue-Wei Qian, Jon K. Reel, Christian C. Felder, John T. Catlow, Rosa Maria A. Simmons, Kevin D. Burris, Kelly L. Knopp, Douglas Linn Gernert, Chunjin Ding, Steven Swanson, Anne B. Need, Theron M. Wall, He Wang, Akihiko Kato, Douglas A. Schober, Ruud Zwart, Benjamin L. Adams, Jeffrey M. Witkin
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 369:345-363
Nonselective glutamate α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonists are efficacious in chronic pain but have significant tolerability issues, likely arising from the ubiquitous expression of AMPA receptors in the
Autor:
Kelly L. Knopp, Akihiko Kato, Michael P. Johnson, Jeff S. McDermott, Theron M. Wall, Benjamin L. Adams, Eric S. Nisenbaum
Publikováno v:
SATURDAY, 15 JUNE 2019.
Background Movement-evoked pain and impaired joint mobility are common comorbidities in inflammatory diseases such as Rheumatoid Arthritis (RA) and Osteoarthritis. The Janus kinase (JAK) pathway has been implicated in both inflammation and chronic pa
Autor:
Kelly L, Knopp, Rosa Maria A, Simmons, Wenhong, Guo, Benjamin L, Adams, Kevin M, Gardinier, Douglas L, Gernert, Paul L, Ornstein, Warren, Porter, Jon, Reel, Chunjin, Ding, He, Wang, Yuewei, Qian, Kevin D, Burris, Anne, Need, Vanessa, Barth, Steven, Swanson, John, Catlow, Jeffrey M, Witkin, Ruud, Zwart, Emanuele, Sher, Kar-Chan, Choong, Theron M, Wall, Douglas, Schober, Christian C, Felder, Akihiko S, Kato, David S, Bredt, Eric S, Nisenbaum
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 369(3)
Nonselective glutamate
Autor:
Daniel P. Walker, Barbara A. Olson, Fusen Han, E. Jon Jacobsen, Raymond S. Hurst, Shaojuan Jia, Lester A. Dolak, Brandon J. Margolis, Nicole R. Higdon, Tatiana N. Vetman, David W. Piotrowski, Brian A. Staton, Matthew R. Hester, Luz A. Cortes-Burgos, Erik H. F. Wong, Theron M. Wall, Steven Charles Reitz, Vincent E. Groppi, Bruce N. Rogers, Kai S. Li, Brad A. Acker, Bruce A. Thornburgh, Paula M. Tinholt, Jason K. Myers, Mihály Hajós, Thomas J. Raub, Mark L. Wolfe, Karen M. Yates, William E. Hoffmann, Laura Fitzgerald, Donn G. Wishka, Eric P. Seest, Rodney R. Walters
Publikováno v:
Bioorganic & Medicinal Chemistry. 14:8219-8248
A novel set of azabicyclic aryl amides have been identified as potent and selective agonists of the alpha7 nAChR. A two-pronged approach was taken to improve the potential hERG liability of previously disclosed alpha7 nAChR agonist, PNU-282,987, whil
Autor:
Arneric Sp, Karen K. Cook, Thomas J. Raub, Bruce N. Rogers, Mark L. Wolfe, Eric Jon Jacobsen, Vincent E. Groppi, Carey G, Brian A. Staton, Daniel P. Walker, Raymond S. Hurst, Luz A. Cortes-Burgos, Rodney R. Walters, Donn G. Wishka, Theron M. Wall, Jia S, Hanchar Aj, Karen M. Yates, Steven B. Sands, Bruce A. Thornburgh, Gold Lh, Soglia, Jason K. Myers, Franklin S, Steven Charles Reitz, Sabrina X. Zhao, Amit S. Kalgutkar, Nicole R. Higdon, Olson Kl, Erik H. F. Wong, Mihály Hajós, William E. Hoffmann
Publikováno v:
Journal of Medicinal Chemistry. 49:4425-4436
N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide (14, PHA-543,613), a novel agonist of the alpha7 neuronal nicotinic acetylcholine receptor (alpha7 nAChR), has been identified as a potential treatment of cognitive deficits in sch
Autor:
Raymond S. Hurst, Vincent E. Groppi, Bruce N. Rogers, Alice L. Bodnar, Theron M. Wall, Luz A. Cortes-Burgos, Jason K. Myers, Dac M. Dinh, Nicole R. Higdon, Mark L. Wolfe, Erik H. F. Wong, Karen K. Cook, Mihály Hajós, William E. Hoffmann
Publikováno v:
Journal of Medicinal Chemistry. 48:905-908
A library of benzamides was tested for alpha7 nicotinic acetylcholine receptor (nAChR) agonist activity using a chimeric receptor in a functional, cell-based, high-throughput assay. From this library, quinuclidine benzamides were found to have alpha7
Autor:
Vincent E. Groppi, Nicole R. Higdon, Raymond S. Hurst, Mihály Hajós, William E. Hoffmann, Michael Krause, Theron M. Wall
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 312:1213-1222
Schizophrenic patients are thought to have an impaired ability to process sensory information. This deficit leads to disrupted auditory gating measured electrophysiologically as a reduced suppression of the second of paired auditoryevoked responses (
Autor:
William R. Humphrey, Caryl L. Lane, Donald C. Anderson, Theron M. Wall, Ronald J. Shebuski, J. Craig Hartman, Ann L. Wiltse, Anthony M. Manning, Craig L. Rosenbloom
Publikováno v:
Cardiovascular Research. 30:47-54
Objective: A blocking monoclonal antibody to intercellular adhesion molecule-1 (ICAM-1), CL18/6, previously has been demonstrated to inhibit neutrophil attachment to isolated vascular endothelium and cardiomyocytes. Due to the well known participatio
Publikováno v:
Journal of Cardiovascular Pharmacology. 21:996-1003
We wished to determine, using a novel specific antagonist of BK2, HOE 140, (a) if the angiotensin-converting enzyme (ACE) inhibitor, ramiprilat, reduces myocardial infarct size in a well-established animal model of ischemia/reperfusion with minimal c
Publikováno v:
European Journal of Pharmacology. 234:229-236
The angiotensin-converting enzyme inhibitor ramiprilat, the angiotensin II receptor antagonist losartan, angiotensin II, ramiprilat plus angiotensin II, or saline (N = 6 each group), were administered i.v. in anesthetized, open-chest rabbit preparati