Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Thergiory Irrazabal"'
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 4, Pp 1177-1197 (2021)
Inflammatory bowel disease (IBD) patients have an increased risk of developing colitis-associated colon cancer (CAC); however, the basis for inflammation-induced genetic damage requisite for neoplasia is unclear. Several studies have shown that IBD p
Externí odkaz:
https://doaj.org/article/df9372db18f54415b3dd1c0b95453e41
Autor:
Thergiory Irrazabal, Bhupesh K. Thakur, Mingsong Kang, Yann Malaise, Catherine Streutker, Erin O. Y. Wong, Julia Copeland, Robert Gryfe, David S. Guttman, William W. Navarre, Alberto Martin
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
It is unclear how microbial-induced inflammation promotes neoplastic transformation in colitis-associated cancer (CAC). Here, the authors use models of CAC to show that inflammation induces 8-oxoguanine lesions in DNA, and that antioxidants can reduc
Externí odkaz:
https://doaj.org/article/526a67a99acf4d7686fe026f8f5cd7e5
Autor:
Conglei Li, Thergiory Irrazabal, Clare C. So, Maribel Berru, Likun Du, Evelyn Lam, Alexanda K. Ling, Jennifer L. Gommerman, Qiang Pan-Hammarström, Alberto Martin
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Class switch recombination (CSR) requires break and repair of immunoglobulin DNA. Here the authors show that the histone deubiquitinase Usp22 is involved in V(D)J recombination and CSR of IgG and IgE, but not IgA, and that IgG CSR is dependent on the
Externí odkaz:
https://doaj.org/article/905ec0c6076f4a6599d3753a0f2a55ca
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 4, Pp 1177-1197 (2021)
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 4, Pp 1177-1197 (2021)
Inflammatory bowel disease (IBD) patients have an increased risk of developing colitis-associated colon cancer (CAC); however, the basis for inflammation-induced genetic damage requisite for neoplasia is unclear. Several studies have shown that IBD p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f8c79d5f17568276f485aec45f7d118
http://europepmc.org/articles/PMC7907812
http://europepmc.org/articles/PMC7907812
Autor:
Catherine J. Streutker, Julia K. Copeland, Alberto Martin, Thergiory Irrazabal, David S. Guttman, Yann Malaise, Robert Gryfe, Erin O. Y. Wong, Mingsong Kang, Bhupesh Kumar Thakur, William Wiley Navarre
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Nature Communications
Inflammatory bowel disease patients have a greatly increased risk of developing colitis-associated colon cancer (CAC); however, the basis for inflammation-induced genetic damage requisite for neoplasia is unclear. Using three models of CAC, we find t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45bb3217d7e52baeb3b82087f2506526
http://link.springer.com/article/10.1038/s41467-020-15549-6
http://link.springer.com/article/10.1038/s41467-020-15549-6
Autor:
Diego A Rodriguez, Sebastian Zamorano, Fernanda Lisbona, Diego Rojas‐Rivera, Hery Urra, Juan R Cubillos‐Ruiz, Ricardo Armisen, Daniel R Henriquez, Emily H Cheng, Michal Letek, Tomas Vaisar, Thergiory Irrazabal, Christian Gonzalez‐Billault, Anthony Letai, Felipe X Pimentel‐Muiños, Guido Kroemer, Claudio Hetz
Publikováno v:
EMBO J
Adaptation to endoplasmic reticulum (ER) stress depends on the activation of the unfolded protein response (UPR) stress sensor inositol-requiring enzyme 1α (IRE1α), which functions as an endoribonuclease that splices the mRNA of the transcription f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::583dc7d77733bfc90c63ceccad5fb767
https://doi.org/10.15252/embj.2021109146
https://doi.org/10.15252/embj.2021109146
Autor:
Charles Maisonneuve, Dana J. Philpott, Thergiory Irrazabal, Stephen E. Girardin, Alberto Martin
Publikováno v:
Annual Review of Cancer Biology. 2:229-249
Colorectal cancer (CRC) represents one of the leading causes of morbidity and cancer-related mortality in the world. While the etiology of CRC is believed to arise from genetic mutations, alterations in the gut microbiota composition also influence c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f8098783e2d0d7118f920c86322be02
https://doi.org/10.1146/annurev-cancerbio-030617-050240
https://doi.org/10.1146/annurev-cancerbio-030617-050240
Autor:
Evelyn Lam, Alexanda K. Ling, Jennifer L. Gommerman, Conglei Li, Alberto Martin, Thergiory Irrazabal, Qiang Pan-Hammarström, Likun Du, Clare C. So, Maribel Berru
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Nature Communications
Nature Communications
Class switch recombination (CSR) has a fundamental function during humoral immune response and involves the induction and subsequent repair of DNA breaks in the immunoglobulin (Ig) switch regions. Here we show the role of Usp22, the SAGA complex deub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7deeae1dc5a458451bf8fd1990824bf5
http://link.springer.com/article/10.1038/s41467-018-03455-x
http://link.springer.com/article/10.1038/s41467-018-03455-x
Autor:
Jorge Ojeda, Sara Fernandez-Collemann, Mirva J. Saaranen, Danilo B. Medinas, Fernando J. Bustos, Viviana Pérez, Johnny Salameh, Alicia Colombo, Paloma Gonzalez-Perez, Natalia Muñoz, Pablo Rozas, Robert H. Brown, Mauricio Torres, Vicente Valenzuela, Lloyd W. Ruddock, Pablo Henny, Miguel L. Concha, Rodrigo Lopez-Gonzalez, Juan Pablo Henríquez, Rene L. Vidal, Alfredo Sagredo, Brigitte van Zundert, Sandra Almeida, Soledad Matus, Thergiory Irrazabal, Mario Campero, Fen-Biao Gao, Catherine I. Andreu, Ute Woehlbier, Ricardo Armisen, Karina Palma, Claudio Hetz
Publikováno v:
EMBO J
Artículos CONICYT
CONICYT Chile
instacron:CONICYT
Artículos CONICYT
CONICYT Chile
instacron:CONICYT
Disturbance of endoplasmic reticulum (ER) proteostasis is a common feature of amyotrophic lateral sclerosis (ALS). Protein disulfide isomerases (PDIs) are ER foldases identified as possible ALS biomarkers, as well as neuroprotective factors. However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93f3762ccb894d457fc7ff27ef704c47
https://doi.org/10.15252/embj.201592224
https://doi.org/10.15252/embj.201592224
Autor:
Thergiory Irrazabal, Alberto Martin
The gut microbiota is a dynamic structure that helps maintain host homeostasis. Recent studies have shown that specific microbes are strongly associated with colorectal cancer development. In addition, patients with colorectal cancer harbor differenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5005c21897097620943c794043b3dab9
https://doi.org/10.1016/b978-0-12-801238-3.65124-3
https://doi.org/10.1016/b978-0-12-801238-3.65124-3
