Zobrazeno 1 - 10
of 155
pro vyhledávání: '"Theresia Kraft"'
Autor:
Nils Kriedemann, Felix Manstein, Carlos A. Hernandez-Bautista, Kevin Ullmann, Wiebke Triebert, Annika Franke, Mira Mertens, Inês Carvalheira Arnaut Pombeiro Stein, Andreas Leffler, Merlin Witte, Tamari Askurava, Veronika Fricke, Ina Gruh, Birgit Piep, Kathrin Kowalski, Theresia Kraft, Robert Zweigerdt
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Background Commonly used media for the differentiation of human pluripotent stem cells into cardiomyocytes (hPSC-CMs) contain high concentrations of proteins, in particular albumin, which is prone to quality variations and presents a substan
Externí odkaz:
https://doaj.org/article/c071a733e7104321b7fcea2933e63725
Autor:
Malgorzata Szaroszyk, Badder Kattih, Abel Martin-Garrido, Felix A. Trogisch, Gesine M. Dittrich, Andrea Grund, Aya Abouissa, Katja Derlin, Martin Meier, Tim Holler, Mortimer Korf-Klingebiel, Katharina Völker, Tania Garfias Macedo, Cristina Pablo Tortola, Michael Boschmann, Nora Huang, Natali Froese, Carolin Zwadlo, Mona Malek Mohammadi, Xiaojing Luo, Michael Wagner, Julio Cordero, Robert Geffers, Sandor Batkai, Thomas Thum, Nadja Bork, Viacheslav O. Nikolaev, Oliver J. Müller, Hugo A. Katus, Ali El-Armouche, Theresia Kraft, Jochen Springer, Gergana Dobreva, Kai C. Wollert, Jens Fielitz, Stephan von Haehling, Michaela Kuhn, Johann Bauersachs, Joerg Heineke
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Cachexia is associated with poor prognosis in heart failure. Here the authors show that mice and patients with cardiac cachexia display reduced skeletal muscle expression and circulating levels of Musclin. Musclin ablation in skeletal muscle worsens,
Externí odkaz:
https://doaj.org/article/95984c1d58cc4de49ae09f7ddb642716
Autor:
Alfredo Jesús López-Dávila, Natalie Weber, Theresia Kraft, Faramarz Matinmehr, Mariela Arias-Hidalgo, Julián Fernández, Bruno Lomonte, José María Gutiérrez
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract Viperid snake venoms contain a unique family of cytotoxic proteins, the Lys49 PLA2 homologs, which are devoid of enzymatic activity but disrupt the integrity of cell membranes. They are known to induce skeletal muscle damage and are therefor
Externí odkaz:
https://doaj.org/article/cc35569f21c0463fa051d26b773f6b04
Autor:
Valentin Burkart, Kathrin Kowalski, David Aldag-Niebling, Julia Beck, Dirk Alexander Frick, Tim Holler, Ante Radocaj, Birgit Piep, Andre Zeug, Denise Hilfiker-Kleiner, Cristobal G. dos Remedios, Jolanda van der Velden, Judith Montag, Theresia Kraft
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
Transcriptional bursting is a common expression mode for most genes where independent transcription of alleles leads to different ratios of allelic mRNA from cell to cell. Here we investigated burst-like transcription and its consequences in cardiac
Externí odkaz:
https://doaj.org/article/b474c750ea6f47e1a619c482725c63c5
Autor:
Kristina Sonnenschein, Jan Fiedler, David de Gonzalo-Calvo, Ke Xiao, Angelika Pfanne, Annette Just, Carolin Zwadlo, Samira Soltani, Udo Bavendiek, Theresia Kraft, Cristobal Dos Remedios, Serghei Cebotari, Johann Bauersachs, Thomas Thum
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Hypertrophic cardiomyopathy (HCM) is one of the most common hereditary heart diseases and can be classified into an obstructive (HOCM) and non-obstructive (HNCM) form. Major characteristics for HCM are the hypertrophy of cardiomyocytes and d
Externí odkaz:
https://doaj.org/article/512e2ec0033c4485af4d7813594d8685
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
In genetic diseases like hypertrophic cardiomyopathy, reliable quantification of the expression level of mutant protein can play an important role in disease research, diagnosis, treatment and prognosis. For heterozygous β-myosin heavy chain (β-MyH
Externí odkaz:
https://doaj.org/article/7aeacab4fcbe4fff8b901d852eef1d29
Autor:
Ariana Foinquinos, Sandor Batkai, Celina Genschel, Janika Viereck, Steffen Rump, Mariann Gyöngyösi, Denise Traxler, Martin Riesenhuber, Andreas Spannbauer, Dominika Lukovic, Natalie Weber, Katrin Zlabinger, Ena Hašimbegović, Johannes Winkler, Jan Fiedler, Seema Dangwal, Martin Fischer, Jeanne de la Roche, Daniel Wojciechowski, Theresia Kraft, Rita Garamvölgyi, Sonja Neitzel, Shambhabi Chatterjee, Xiaoke Yin, Christian Bär, Manuel Mayr, Ke Xiao, Thomas Thum
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
miR-132 was shown to drive pathological cardiac remodeling, a hallmark of heart failure. Here, the authors show that an antisense inhibitor of miR-132 has favourable pharmacokinetics, safety-tolerability and preclinical efficacy in mouse and porcine
Externí odkaz:
https://doaj.org/article/33579ddb7f504de8ad9792e4fd12c4d2
Autor:
Caroline Halloin, Kristin Schwanke, Wiebke Löbel, Annika Franke, Monika Szepes, Santoshi Biswanath, Stephanie Wunderlich, Sylvia Merkert, Natalie Weber, Felix Osten, Jeanne de la Roche, Felix Polten, Kai Wollert, Theresia Kraft, Martin Fischer, Ulrich Martin, Ina Gruh, Henning Kempf, Robert Zweigerdt
Publikováno v:
Stem Cell Reports, Vol 13, Iss 2, Pp 366-379 (2019)
Summary: Aiming at clinical translation, robust directed differentiation of human pluripotent stem cells (hPSCs), preferentially in chemically defined conditions, is a key requirement. Here, feasibility of suspension culture based hPSC-cardiomyocyte
Externí odkaz:
https://doaj.org/article/5bf4901f96304fee8eb8aff796b40560
Autor:
Emilie Auxerre-Plantié, Tanja Nielsen, Marcel Grunert, Olga Olejniczak, Andreas Perrot, Cemil Özcelik, Dennis Harries, Faramarz Matinmehr, Cristobal Dos Remedios, Christian Mühlfeld, Theresia Kraft, Rolf Bodmer, Georg Vogler, Silke R. Sperling
Publikováno v:
Disease Models & Mechanisms, Vol 13, Iss 12 (2020)
The causal genetic underpinnings of congenital heart diseases, which are often complex and multigenic, are still far from understood. Moreover, there are also predominantly monogenic heart defects, such as cardiomyopathies, with known disease genes f
Externí odkaz:
https://doaj.org/article/3ad5653fc6794cb9940a877a8adecd22
Autor:
Alfredo Jesus López-Dávila, Joseph M. Chalovich, Stefan Zittrich, Birgit Piep, Faramarz Matinmehr, Andras Málnási-Csizmadia, Anna Á. Rauscher, Theresia Kraft, Bernhard Brenner, Robert Stehle
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
It has been shown that not only calcium but also strong binding myosin heads contribute to thin filament activation in isometrically contracting animal fast-twitch and cardiac muscle preparations. This behavior has not been studied in human muscle fi
Externí odkaz:
https://doaj.org/article/44a2581e2ee844f2b914999690386b9e