A neuronal mechanism underlying decision-making deficits during hyperdopaminergic states

Autor: Jeroen P. H. Verharen, Johannes W. de Jong, Theresia J. M. Roelofs, Christiaan F. M. Huffels, Ruud van Zessen, Mieneke C. M. Luijendijk, Ralph Hamelink, Ingo Willuhn, Hanneke E. M. den Ouden, Geoffrey van der Plasse, Roger A. H. Adan, Louk J. M. J. Vanderschuren

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)

Aberrant increased dopaminergic function results in impaired value-based decision making. Here the authors report pathway-specific effects of VTA activation on distinct aspects of flexible value-based decisions in rats.

Externí odkaz: https://doaj.org/article/31622733c1f8444ca230c79f49f730a9

Good taste or gut feeling? A new method in rats shows oro-sensory stimulation and gastric distention generate distinct and overlapping brain activation patterns

Autor: Roger A.H. Adan, Guido Camps, Rick M. Dijkhuizen, Paul A.M. Smeets, Mieneke C. M. Luijendijk, Theresia J. M. Roelofs, Annette van der Toorn

Publikováno v: International Journal of Eating Disorders, 54(7), 1116-1126
The International Journal of Eating Disorders
International Journal of Eating Disorders 54 (2021) 7

Satiation is influenced by a variety of signals including gastric distention and oro‐sensory stimulation. Here we developed a high‐field (9.4 T) functional magnetic resonance imaging (fMRI) protocol to test how oro‐sensory stimulation and gastr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03426d1d10d6af6b1898b0d54a8187f0
https://research.wur.nl/en/publications/good-taste-or-gut-feeling-a-new-method-in-rats-shows-oro-sensory-

Distinct structure-function relationships across cortical regions and connectivity scales in the rat brain

Autor: Michel R.T. Sinke, Rick M. Dijkhuizen, Oliver Schmitt, Theresia J. M. Roelofs, Erwin L. A. Blezer, Annette van der Toorn, Milou Straathof, R. Angela Sarabdjitsingh, Willem M. Otte

Publikováno v: Scientific Reports, 10(1). Nature Publishing Group
Scientific reports, 10(1). Nature Publishing Group
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports

An improved understanding of the structure-function relationship in the brain is necessary to know to what degree structural connectivity underpins abnormal functional connectivity seen in disorders. We integrated high-field resting-state fMRI-based

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5836c92cfb720fde0e3a1d004f39032e
https://doi.org/10.1038/s41598-019-56834-9

A novel approach to map induced activation of neuronal networks using chemogenetics and functional neuroimaging in rats : A proof-of-concept study on the mesocorticolimbic system

Autor: Willem M. Otte, Roger A.H. Adan, Geralda A. F. van Tilborg, Theresia J. M. Roelofs, Rick M. Dijkhuizen, Mieneke C. M. Luijendijk, Annette van der Toorn, Johannes W. de Jong, Linde Boekhoudt, Jeroen P.H. Verharen

Publikováno v: NeuroImage, 156, 109. Academic Press Inc.

Linking neural circuit activation at whole-brain level to neuronal activity at cellular level remains one of the major challenges in neuroscience research. We set up a novel functional neuroimaging approach to map global effects of locally induced ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac5017224c94f75fd994d0553b02906c
https://hdl.handle.net/1874/349677