Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Theresia Conrad"'
Autor:
Yuen Lam Dora Ng, Evelyn Ramberger, Stephan R. Bohl, Anna Dolnik, Christian Steinebach, Theresia Conrad, Sina Müller, Oliver Popp, Miriam Kull, Mohamed Haji, Michael Gütschow, Hartmut Döhner, Wolfgang Walther, Ulrich Keller, Lars Bullinger, Philipp Mertins, Jan Krönke
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Acquired resistance to immunomodulatory drugs is common in multiple myeloma patients, but rarely attributed to genetic alterations. Here, proteomic, phosphoproteomic and RNA sequencing analysis in five paired pre-treatment and relapse samples reveals
Externí odkaz:
https://doaj.org/article/d4504678ee754ca4b1b981178e24fb56
Autor:
Dennis Gürgen, Theresia Conrad, Michael Becker, Susanne Sebens, Christoph Röcken, Jens Hoffmann, Stefan Langhammer
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-10 (2022)
The identification of novel therapeutic strategies for advanced non-small cell lung cancer (NSCLC) is essential as the outcome of most of these patients is poor. Here the authors provide a proof-of concept that specific low-dose drug combinations can
Externí odkaz:
https://doaj.org/article/92f28987a8ba465c999b6d45aa1fdeb2
Autor:
Philipp Kämmer, Sylvie McNamara, Thomas Wolf, Theresia Conrad, Stefanie Allert, Franziska Gerwien, Kerstin Hünniger, Oliver Kurzai, Reinhard Guthke, Bernhard Hube, Jörg Linde, Sascha Brunke
Publikováno v:
mBio, Vol 11, Iss 5 (2020)
ABSTRACT Only four species, Candida albicans, C. glabrata, C. parapsilosis, and C. tropicalis, together account for about 90% of all Candida bloodstream infections and are among the most common causes of invasive fungal infections of humans. However,
Externí odkaz:
https://doaj.org/article/f2fe89eb2bd349eb97a5aea2719f38fa
Autor:
Iordana A. Shopova, Ivan Belyaev, Prasad Dasari, Susanne Jahreis, Maria C. Stroe, Zoltán Cseresnyés, Ann-Kathrin Zimmermann, Anna Medyukhina, Carl-Magnus Svensson, Thomas Krüger, Viktòria Szeifert, Sandor Nietzsche, Theresia Conrad, Matthew G. Blango, Olaf Kniemeyer, Marie von Lilienfeld-Toal, Peter F. Zipfel, Erzsébet Ligeti, Marc Thilo Figge, Axel A. Brakhage
Publikováno v:
mBio, Vol 11, Iss 2 (2020)
ABSTRACT Polymorphonuclear granulocytes (PMNs) are indispensable for controlling life-threatening fungal infections. In addition to various effector mechanisms, PMNs also produce extracellular vesicles (EVs). Their contribution to antifungal defense
Externí odkaz:
https://doaj.org/article/0c73dfd61b2a43bf9cf5f653d3927aec
Autor:
Mario M. Müller, Roland Lehmann, Tilman E. Klassert, Stella Reifenstein, Theresia Conrad, Christoph Moore, Anna Kuhn, Andrea Behnert, Reinhard Guthke, Dominik Driesch, Hortense Slevogt
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract Exposure of human monocytes to lipopolysaccharide (LPS) induces a temporary insensitivity to subsequent LPS challenges, a cellular state called endotoxin tolerance. In this study, we investigated the LPS-induced global glycoprotein expressio
Externí odkaz:
https://doaj.org/article/7933dd5b970a4a05a24a95607778d7de
Autor:
Theresia Conrad, Johannes Haybaeck, Marie-Laure Yaspo, Marlen Keil, Michael Becker, Jens Hoffmann, Ulrich Keilholz, Moritz Schütte, Hans Lehrach
Publikováno v:
cancers
Cancers; Volume 13; Issue 23; Pages: 6018
Cancers
Cancers, Vol 13, Iss 6018, p 6018 (2021)
Cancers; Volume 13; Issue 23; Pages: 6018
Cancers
Cancers, Vol 13, Iss 6018, p 6018 (2021)
Simple Summary This experimental preclinical study developed a strategy to identify signatures for the personalized treatment of colon cancer focusing on target-specific drug combinations. Tumor growth inhibition was analyzed in a preclinical phase I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8ba098cf97d875882f53f344de36b1f
https://hdl.handle.net/21.11116/0000-0009-BFAD-E21.11116/0000-0009-BFAB-0
https://hdl.handle.net/21.11116/0000-0009-BFAD-E21.11116/0000-0009-BFAB-0
Autor:
Christoph Roecken, Theresia Conrad, Dennis Guergen, Susanne Sebens, Michael Becker, Jens Hoffmann, Stefan Langhammer
Non-small cell lung cancer (NSCLC) is commonly diagnosed at advanced stages limiting treatment options. Although, targeted therapy has become integral part of NSCLC treatment therapies often fail to improve patient’s prognosis. Based on previously
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a417eeb363896ce2cfeac53685509cfb
https://doi.org/10.1101/2021.10.23.465545
https://doi.org/10.1101/2021.10.23.465545
Autor:
Dennis Gürgen, Theresia Conrad, Michael Becker, Susanne Sebens, Christoph Röcken, Jens Hoffmann, Stefan Langhammer
Publikováno v:
Communications Biology
Communications Biology, Vol 5, Iss 1, Pp 1-10 (2022)
Communications Biology, Vol 5, Iss 1, Pp 1-10 (2022)
Non-small cell lung cancer (NSCLC) is commonly diagnosed at advanced stages limiting treatment options. Although, targeted therapy has become integral part of NSCLC treatment therapies often fail to improve patient’s prognosis. Based on previously
Autor:
Dennis Gürgen, Theresia Conrad, Michael Becker, Susanne Sebens, Christoph Röcken, Jens Hoffmann, Stefan Langhammer
Publikováno v:
Cancer Research. 82:3095-3095
Background: Non-small cell lung cancer (NSCLC) is commonly diagnosed at advanced stages with limited treatment options particularly in tumors without targetable driver mutations. Methods: Considering previously published criteria for selecting drug c
Autor:
Reinhard Guthke, Bernhard Hube, Sylvie McNamara, Kerstin Hünniger, Thomas Wolf, Theresia Conrad, Jörg Linde, Oliver Kurzai, Sascha Brunke, Stefanie Allert, Franziska Gerwien, Philipp Kämmer
Publikováno v:
mBio, Vol 11, Iss 5 (2020)
mBio
mBio
To ensure their survival, pathogens have to adapt immediately to new environments in their hosts, for example, during the transition from the gut to the bloodstream. Here, we investigated the basis of this adaptation in a group of fungal species whic