Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Therese-Marie Stachyra"'
Autor:
Martin Schröder, Martin Renatus, Xiaoyou Liang, Fabian Meili, Thomas Zoller, Sandrine Ferrand, Francois Gauter, Xiaoyan Li, Frederic Sigoillot, Scott Gleim, Therese-Marie Stachyra, Jason R. Thomas, Damien Begue, Maryam Khoshouei, Peggy Lefeuvre, Rita Andraos-Rey, BoYee Chung, Renate Ma, Benika Pinch, Andreas Hofmann, Markus Schirle, Niko Schmiedeberg, Patricia Imbach, Delphine Gorses, Keith Calkins, Beatrice Bauer-Probst, Magdalena Maschlej, Matt Niederst, Rob Maher, Martin Henault, John Alford, Erik Ahrne, Luca Tordella, Greg Hollingworth, Nicolas H. Thomä, Anna Vulpetti, Thomas Radimerski, Philipp Holzer, Seth Carbonneau, Claudio R. Thoma
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-5 (2024)
Externí odkaz:
https://doaj.org/article/1168651eade84aa68bb9c377c9befbde
Autor:
Martin Schröder, Martin Renatus, Xiaoyou Liang, Fabian Meili, Thomas Zoller, Sandrine Ferrand, Francois Gauter, Xiaoyan Li, Frederic Sigoillot, Scott Gleim, Therese-Marie Stachyra, Jason R. Thomas, Damien Begue, Maryam Khoshouei, Peggy Lefeuvre, Rita Andraos-Rey, BoYee Chung, Renate Ma, Benika Pinch, Andreas Hofmann, Markus Schirle, Niko Schmiedeberg, Patricia Imbach, Delphine Gorses, Keith Calkins, Beatrice Bauer-Probst, Magdalena Maschlej, Matt Niederst, Rob Maher, Martin Henault, John Alford, Erik Ahrne, Luca Tordella, Greg Hollingworth, Nicolas H. Thomä, Anna Vulpetti, Thomas Radimerski, Philipp Holzer, Seth Carbonneau, Claudio R. Thoma
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Targeted protein degradation (TPD) mediates protein level through small molecule induced redirection of E3 ligases to ubiquitinate neo-substrates and mark them for proteasomal degradation. TPD has recently emerged as a key modality in drug d
Externí odkaz:
https://doaj.org/article/8f2eff537f564b01931321a688bb396a
Autor:
William R. Sellers, Francesco Hofmann, Michael R. Jensen, Marion Wiesmann, Emil Kuriakose, Audrey Kauffmann, Astrid Jullion, Ensar Halilovic, Nelson Guerreiro, Jens Würthner, Pascal Furet, Joerg Kallen, Therese-Marie Stachyra, Stephan Ruetz, Marta Cortes-Cros, Swann Gaulis, Eric Y. Durand, Grainne Kerr, Masato Murakami, Vincent Romanet, Dario Sterker, Markus Wartmann, Emilie A. Chapeau, Jeanette Fuchs, Philipp Holzer, Stéphane Ferretti, Sébastien Jeay
Median of the shRNAs and RSA values. File containing median counts and log fold changes of each gene from Supplementary Data File S1. According significance values of each gene as activator or sensitizer compared to DMSO control (see Methods) are inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9fb2879a6749b92d41888b92af04a38
https://doi.org/10.1158/0008-5472.22420067.v1
https://doi.org/10.1158/0008-5472.22420067.v1
Autor:
William R. Sellers, Francesco Hofmann, Michael R. Jensen, Marion Wiesmann, Emil Kuriakose, Audrey Kauffmann, Astrid Jullion, Ensar Halilovic, Nelson Guerreiro, Jens Würthner, Pascal Furet, Joerg Kallen, Therese-Marie Stachyra, Stephan Ruetz, Marta Cortes-Cros, Swann Gaulis, Eric Y. Durand, Grainne Kerr, Masato Murakami, Vincent Romanet, Dario Sterker, Markus Wartmann, Emilie A. Chapeau, Jeanette Fuchs, Philipp Holzer, Stéphane Ferretti, Sébastien Jeay
Activation of p53 by inhibitors of the p53–MDM2 interaction is being pursued as a therapeutic strategy in p53 wild-type cancers. Here, we report distinct mechanisms by which the novel, potent, and selective inhibitor of the p53–MDM2 interaction H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::defcbf6d8ab85cdf500b16956270b3ec
https://doi.org/10.1158/0008-5472.c.6510551.v1
https://doi.org/10.1158/0008-5472.c.6510551.v1
Autor:
William R. Sellers, Francesco Hofmann, Michael R. Jensen, Marion Wiesmann, Emil Kuriakose, Audrey Kauffmann, Astrid Jullion, Ensar Halilovic, Nelson Guerreiro, Jens Würthner, Pascal Furet, Joerg Kallen, Therese-Marie Stachyra, Stephan Ruetz, Marta Cortes-Cros, Swann Gaulis, Eric Y. Durand, Grainne Kerr, Masato Murakami, Vincent Romanet, Dario Sterker, Markus Wartmann, Emilie A. Chapeau, Jeanette Fuchs, Philipp Holzer, Stéphane Ferretti, Sébastien Jeay
Supplementary material and methods include the description for the bioanalytical method for HDM201 detection in plasma and tumor, the human and mouse gene expression analysis in vitro and in vivo, the live-cell quantification of cleaved-caspase activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b82fed93efadb9ad16a5268c6dd4a1d
https://doi.org/10.1158/0008-5472.22420061
https://doi.org/10.1158/0008-5472.22420061
Autor:
Samuel Hintermann, Andreas Marzinzik, Johannes Ottl, Joerg Kallen, Therese-Marie Stachyra, Patrick C. Reid, Stephan Ruetz, Anselm F. L. Schneider, Christian P. R. Hackenberger, Christoph E. Dumelin, Sebastien Ripoche
Publikováno v:
RSC Chemical Biology
Mouse double minute 2 homolog (MDM2, Hdm2) is an important negative regulator of the tumor suppressor p53. Using a mRNA based display technique to screen a library of >1012in vitro-translated cyclic peptides, we have identified a macrocyclic ligand t
Autor:
Emil T. Kuriakose, Vincent Romanet, Swann Gaulis, Philipp Holzer, Grainne Kerr, Nelson Guerreiro, Dario Sterker, Emilie A. Chapeau, Astrid Jullion, Jeanette Fuchs, Francesco Hofmann, Sébastien Jeay, Jens Würthner, Masato Murakami, Joerg Kallen, Stephan Ruetz, Audrey Kauffmann, Marta Cortes-Cros, Pascal Furet, Therese-Marie Stachyra, William R. Sellers, Markus Wartmann, Michael Rugaard Jensen, Marion Wiesmann, Eric Durand, Stephane Ferretti, Ensar Halilovic
Publikováno v:
Cancer Research. 78:6257-6267
Activation of p53 by inhibitors of the p53–MDM2 interaction is being pursued as a therapeutic strategy in p53 wild-type cancers. Here, we report distinct mechanisms by which the novel, potent, and selective inhibitor of the p53–MDM2 interaction H
Autor:
Markus Kaufmann, Frédéric Baysang, Amanda Cobos-Correa, Pascal Furet, Therese-Marie Stachyra, Andreas Marzinzik, Nicole Buschmann, Pier Luca D’Alessandro, Johannes Ottl, Dimitrios Lizos, Reto Brunner, Thomas Vorherr
Publikováno v:
Angewandte Chemie International Edition. 55:16026-16030
To study the behavior of MDM2-p53 inhibitors in a disease-relevant cellular model, we have developed and validated a set of bioorthogonal probes that can be fluorescently labeled in cells and used in high-content screening assays. By using automated
Autor:
François Gessier, Robert Mah, Philipp Holzer, Therese-Marie Stachyra, Andrea Vaupel, Vito Guagnano, Emmanuelle Wirth, Patrick Chène, Pascal Furet, Joseph Schoepfer, Aude Izaac, Bahaa Salem, Stefan Stutz, Joerg Kallen, Keiichi Masuya, Achim Schlapbach, Suzanne Chau
Publikováno v:
ChemMedChem. 14(14)
Hdm2 (human MDM2, human double minute 2 homologue) counteracts p53 function by direct binding to p53 and by ubiquitin-dependent p53 protein degradation. Activation of p53 by inhibitors of the p53-Hdm2 interaction is being pursued as a therapeutic str
Autor:
Aude Izaac, Stefan Stutz, Patrick Chène, Emmanuelle Wirth, Achim Schlapbach, Keiichi Masuya, François Gessier, Robert Mah, Bahaa Salem, Andrea Vaupel, Therese-Marie Stachyra, Philipp Holzer, Vito Guagnano, Joseph Schoepfer, Pascal Furet, Joerg Kallen, Suzanne Chau
Publikováno v:
ChemMedChem. 14:1304-1304