Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Therese Stachyra"'
Autor:
Melusine Bleu, Fanny Mermet-Meillon, Verena Apfel, Louise Barys, Laura Holzer, Marianne Bachmann Salvy, Rui Lopes, Inês Amorim Monteiro Barbosa, Cecile Delmas, Alexandra Hinniger, Suzanne Chau, Markus Kaufmann, Simon Haenni, Karolin Berneiser, Maria Wahle, Ivana Moravec, Alexandra Vissières, Tania Poetsch, Erik Ahrné, Nathalie Carte, Johannes Voshol, Elisabeth Bechter, Jacques Hamon, Marco Meyerhofer, Dirk Erdmann, Matteo Fischer, Therese Stachyra, Felix Freuler, Sascha Gutmann, César Fernández, Tobias Schmelzle, Ulrike Naumann, Guglielmo Roma, Kate Lawrenson, Cristina Nieto-Oberhuber, Amanda Cobos-Correa, Stephane Ferretti, Dirk Schübeler, Giorgio Giacomo Galli
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Lineage-restricted transcription factor PAX8 is oncogenic in ovarian cancer cells. Here the authors show that PAX8 interacts and recruits a splice variant of the MECOM locus PRDM3 to control the gene expression module involved in adhesion and extrace
Externí odkaz:
https://doaj.org/article/e459f346777c48fab385e6b2235f6c4c
Autor:
Martin Schröder, Martin Renatus, Xiaoyou Liang, Fabian Meili, Thomas Zoller, Sandrine Ferrand, Francois Gauter, Xiaoyan Li, Fred Sigoillot, Scott Gleim, Marie-Therese Stachyra, Jason Thomas, Damien Begue, Peggy Lefeuvre, Rita Andraos-Rey, BoYee Chung, Renate Ma, Seth Carbonneau, Benika Pinch, Andreas Hofmann, Markus Schirle, Niko Schmiedberg, Patricia Imbach, Delphine Gorses, Keith Calkins, Bea Bauer-Probst, Magdalena Maschlej, Matt Niederst, Rob Maher, Martin Henault, John Alford, Erik Ahrne, Greg Hollingworth, Nicolas H. Thomä, Anna Vulpetti, Thomas Radimerski, Philipp Holzer, Claudio R. Thoma
Targeted protein degradation (TPD) of neo-substrates with proteolysis targeting chimeras (PROTACs) or molecular glues has emerged as a key modality in exploring new biology as well as designing new drug candidates where catalytic inhibition is neithe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b962ac1012caadf747a15217539d973e
https://doi.org/10.1101/2023.04.09.536153
https://doi.org/10.1101/2023.04.09.536153
Autor:
Johannes Voshol, Therese Stachyra, Alexandra Vissieres, Elisabeth Bechter, Verena Apfel, Erik Ahrné, Maria Wahle, Suzanne Chau, Ivana Moravec, Karolin Fiona Berneiser, Nathalie Carte, Tania Poetsch, Rui Lopes, Dirk Schübeler, Simon Haenni, Markus Kaufmann, Stephane Ferretti, Dirk Erdmann, Alexandra Hinniger, Marianne Bachmann Salvy, Jacques Hamon, Guglielmo Roma, Amanda Cobos-Correa, Ulrike Naumann, César Fernández, Louise Barys, Cristina Nieto-Oberhuber, Giorgio G. Galli, Melusine Bleu, Matteo Fischer, Felix Freuler, Sascha Gutmann, Kate Lawrenson, Fanny Mermet-Meillon, Tobias Schmelzle, Cecile Delmas, Laura Holzer, Marco Meyerhofer, Ines Barbosa
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
The transcription factor PAX8 is critical for the development of the thyroid and urogenital system. Comprehensive genomic screens furthermore indicate an additional oncogenic role for PAX8 in renal and ovarian cancers. While a plethora of PAX8-regula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0aaf78d1de96ff3b8d6880ccacc7215a
https://pubmed.ncbi.nlm.nih.gov/33903593
https://pubmed.ncbi.nlm.nih.gov/33903593
Autor:
Therese Stachyra, Stephan Ruetz, Rike Wallbrecher, Patrick Chène, Roland Brock, Thomas Vorherr
Publikováno v:
British Journal of Pharmacology. 174:2613-2622
Background and Purpose Helix stapling enhances the activity of peptides that interact with a target protein in a helical conformation. These staples are also supposed to change the pharmacokinetics of the molecules and promote cytoplasmic targeting.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3bce7ad6c759d0e1511593065de1c643
https://doi.org/10.1111/bph.13834
https://doi.org/10.1111/bph.13834
Autor:
Robert Mah, Sébastien Jeay, Milen Todorov, Stephan Ruetz, Caroline Rynn, Stefan Stutz, Philipp Holzer, Pascal Furet, Joerg Kallen, Stephane Ferretti, Therese Stachyra, Achim Schlapbach, Keiichi Masuya, Vito Guagnano, Andrea Vaupel
Publikováno v:
Bioorganicmedicinal chemistry letters. 28(20)
Small molecule inhibitors of the p53-MDM2 protein complex are under intense investigation in clinical trials as anti-cancer agents, including our first generation inhibitor NVP-CGM097. We recently described the rational design of a novel pyrazolopyrr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28f34c1be3db54c41b2dec1e6dd750b3
https://pubmed.ncbi.nlm.nih.gov/30217415
https://pubmed.ncbi.nlm.nih.gov/30217415
Autor:
Furet, Pascal, Chène, Patrick, De Pover, Alain, Valat, Thérèse Stachyra, Lisztwan, Joanna Hergovich, Kallen, Joerg, Masuya, Keiichi
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 15 May 2012 22(10):3498-3502