Zobrazeno 1 - 10
of 112
pro vyhledávání: '"Therese M, Becker"'
Autor:
Tanzila Khan, John G. Lock, Yafeng Ma, David G. Harman, Paul de Souza, Wei Chua, Bavanthi Balakrishnar, Kieran F. Scott, Therese M. Becker
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract Androgen receptor variant 7 (AR-V7) is an important biomarker to guide treatment options for castration-resistant prostate cancer (CRPC) patients. Its detectability in circulating tumour cells (CTCs) opens non-invasive diagnostic avenues. Wh
Externí odkaz:
https://doaj.org/article/d06bbbb8a6c34c748da9fb0465a71580
Autor:
Benedicte Grebstad Tune, Heena Sareen, Branka Powter, Smadar Kahana-Edwin, Adam Cooper, Eng-Siew Koh, Cheok S. Lee, Joseph W. Po, Geoff McCowage, Mark Dexter, Lucy Cain, Geraldine O’Neill, Victoria Prior, Jonathan Karpelowsky, Maria Tsoli, Lars O. Baumbusch, David Ziegler, Tara L. Roberts, Paul DeSouza, Therese M. Becker, Yafeng Ma
Publikováno v:
Biomedicines, Vol 11, Iss 11, p 2907 (2023)
Genetic histone variants have been implicated in cancer development and progression. Mutations affecting the histone 3 (H3) family, H3.1 (encoded by HIST1H3B and HIST1H3C) and H3.3 (encoded by H3F3A), are mainly associated with pediatric brain cancer
Externí odkaz:
https://doaj.org/article/444c9199ff6b4d05bfdb45dd6101a100
Autor:
A-M Joëlle Marivel, Yafeng Ma, Therese M. Becker, Anvita Verma, Steven Trieu, Tara L. Roberts, Silvia C.W. Ling
Publikováno v:
Leukemia Research Reports, Vol 20, Iss , Pp 100393- (2023)
Multiple myeloma (MM) is an incurable haematological malignancy which relies heavily on bone marrow biopsies for disease monitoring and prediction of treatment response. In recent years, liquid biopsy derived cell-free DNA (cfDNA) has emerged as alte
Externí odkaz:
https://doaj.org/article/35d85e00910149f18598e25d980d87a8
Autor:
Udit Nindra, Abhijit Pal, Vivienne Lea, Stephanie Hui-Su Lim, Kate Wilkinson, Ray Asghari, Tara L Roberts, Therese M Becker, Mahtab Farzin, Tristan Rutland, Mark Lee, Scott MacKenzie, Weng Ng, Bin Wang, C Soon Lee, Wei Chua
Publikováno v:
PLoS ONE, Vol 18, Iss 10, p e0292087 (2023)
BackgroundNext generation sequencing (NGS) is increasingly used in standard clinical practice to identify patients with potentially actionable mutations. Stratification of NGS mutation tiers is currently based on the European Society of Medical Oncol
Externí odkaz:
https://doaj.org/article/96a4f02f3945468bab367622f96e9e7b
Autor:
Sarah A. Jeffreys, Therese M. Becker, Sarah Khan, Patsy Soon, Hans Neubauer, Paul de Souza, Branka Powter
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
BackgroundUp to 80% of breast cancers (BCa) are estrogen receptor positive and current treatments target the estrogen receptor (endocrine therapies) and/or CDK4/6 (CDK4/6 inhibitors). CCND1 encodes the protein cyclin D1, responsible for regulation of
Externí odkaz:
https://doaj.org/article/38ad87533aa74a16b72faaaecd6ad7b3
Autor:
Tanzila Khan, Therese M. Becker, Kieran F. Scott, Joseph Descallar, Paul de Souza, Wei Chua, Yafeng Ma
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
In advanced prostate cancer, access to recent diagnostic tissue samples is restricted and this affects the analysis of the association of evolving biomarkers such as AR-V7 with metastatic castrate resistance. Liquid biopsies are emerging as alternati
Externí odkaz:
https://doaj.org/article/f49a2e4f887b4cfcbf27f2a6908ceef4
Autor:
Allal Ouhtit, Ishita Gupta, Rajiv L. Gaur, Augusta Fernando, Amira O. Abd El-Azim, Ali Eid, Therese M Becker
Publikováno v:
Frontiers in Bioscience-Elite, Vol 12, Iss 2, Pp 223-236 (2020)
We have previously characterized the role of p16/Rb in coordinating the early events in UVB-irradiated skin. As an extension to this work, normal melanocytes and mutant p16-inducible melanoma cell models were employed to elucidate further the coordin
Externí odkaz:
https://doaj.org/article/71940ba4fe864703b04019c06a0e81a9
Autor:
Puneet Singh, Paul de Souza, Kieran F. Scott, Bruce M. Hall, Nirupama D. Verma, Therese M. Becker, James W. T. Toh, Mila Sajinovic, Kevin J. Spring
Publikováno v:
Translational Medicine Communications, Vol 4, Iss 1, Pp 1-13 (2019)
Abstract Although durable clinical responses are achieved in a significant number of patients given Immune checkpoint inhibitors (ICI), like anti-CTLA-4 and anti-PD-1 inhibitors, some of the cancers have shown little or no response to ICI therapy. Ev
Externí odkaz:
https://doaj.org/article/5e7bfbc3b7b54f42ba821c6a42ac4cb0
Autor:
Celine Garrett, Therese M Becker, David Lynch, Joseph Po, Wei Xuan, Kieran F Scott, Paul de Souza
Publikováno v:
PLoS ONE, Vol 16, Iss 6, p e0252614 (2021)
ObjectivePre- and post-operative neutrophil to lymphocyte ratio (NLR) and prognostic nutritional index (PNI) and other prognostic clinicopathological variables were correlated with progression free survival (PFS) and overall survival (OS) of Glioblas
Externí odkaz:
https://doaj.org/article/e4bf37e11aa240dcac614cbaa80d6585
Autor:
Tanzila Khan, Kieran F. Scott, Therese M. Becker, John Lock, Mohammed Nimir, Yafeng Ma, Paul de Souza
Publikováno v:
Prostate Cancer, Vol 2020 (2020)
Prostate cancer (PCa) is initially driven by excessive androgen receptor (AR) signaling with androgen deprivation therapy (ADT) being a major therapeutic approach to its treatment. However, the development of drug resistance is a significant limitati
Externí odkaz:
https://doaj.org/article/11e6256a7b5a4cc59b14b4cca3ac9fbd