Výsledky vyhledávání - "Therese H Røst"

Akademický článek

Inflammatory markers, the tryptophan-kynurenine pathway, and vitamin B status after bariatric surgery.

Autor: Monika H E Christensen, Dag J Fadnes, Therese H Røst, Eva R Pedersen, John R Andersen, Villy Våge, Arve Ulvik, Øivind Midttun, Per M Ueland, Ottar K Nygård, Gunnar Mellgren

Publikováno v: PLoS ONE, Vol 13, Iss 2, p e0192169 (2018)

Obesity is associated with increased inflammation and insulin resistance. In conditions with chronic immune activation, low plasma vitamin B6-levels are described, as well as an increased kynurenine:tryptophan-ratio (KTR). We investigated circulating

Externí odkaz: https://doaj.org/article/8c94532a15ff4822a5fb6843d6c1b189

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Absence of the proteoglycan decorin reduces glucose tolerance in overfed male mice

Autor: Gunnar Mellgren, Anne E. Mellgren, Eyvind Rødahl, Camilla E. N. Sommervoll, Simon N. Dankel, Jessica Svärd, Therese H. Røst, Johan Fernø, Christine Haugen, Jørn V. Sagen, Oddrun Anita Gudbrandsen

Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports

Studies have implicated the extracellular matrix (ECM) of adipose tissue in insulin resistance. The proteoglycan decorin, a component of ECM, has been associated with glucose tolerance, but possible causal effects on metabolism remain to be explored.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98e29fd9698369b43cfae5ebca1fbce2
http://link.springer.com/article/10.1038/s41598-018-37501-x

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The Rho GTPase RND3 regulates adipocyte lipolysis

Autor: Simon N. Dankel, Thomas Skurk, Gunnar Mellgren, Agné Kulyté, Zinayida Fandalyuk, Peter Arner, Jørn V. Sagen, Hans Hauner, Therese H. Røst, Mikael Rydén

Publikováno v: Metabolism: Clinical and Experimental

Background: Adipose tissue plays a crucial role in diet- and obesity-related insulin resistance, with implications for several metabolic diseases. Identification of novel target genes and mechanisms that regulate adipocyte function could lead to impr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54e3d46441d87ea78758dee98d9df7dc
https://doi.org/10.1016/j.metabol.2019.153999

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Synthesis of novel PPARα/γ dual agonists as potential drugs for the treatment of the metabolic syndrome and diabetes type II designed using a new de novo design programprotobuild

Autor: R. G. Cooper, Yushma Bhurruth-Alcor, Andrew D. Miller, Joseph M. Sheridan, Therese H. Røst, Rolf K. Berge, Michael R. Jorgensen, Christos Kontogiorgis, Jonathan R. Heal, Jon Skorve, William D.O. Hamilton

Publikováno v: Org. Biomol. Chem.. 9:1169-1188

Peroxisome proliferator activated receptors (PPARs) have been shown to have critical roles in fatty acid oxidation, triglyceride synthesis, and lipid metabolism - making them an important target in drug discovery. Here we describe the in silico desig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04565d632c75cd92bf668e4268595402
https://doi.org/10.1039/c0ob00146e

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A pan-PPAR ligand induces hepatic fatty acid oxidation in PPARα−/− mice possibly through PGC-1 mediated PPARδ coactivation

Autor: Gunnar Mellgren, Line L. Haugan Moi, Rolf K. Berge, Kjetil Berge, Therese H. Røst, Bart Staels

Publikováno v: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1791:1076-1083

Tetradecylthioacetic acid (TTA) is a hypolipidemic modified fatty acid and a peroxisome proliferator-activated receptor (PPAR) ligand. The mechanisms of TTA-mediated effects seem to involve the PPARs, but the effects have not been assigned to any spe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f91466ea6c9b2a80bacc81b6f4ffa833
https://doi.org/10.1016/j.bbalip.2009.06.005

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Tetradecylthioacetic acid attenuates dyslipidaemia in male patients with type 2 diabetes mellitus, possibly by dual PPAR-α/δ activation and increased mitochondrial fatty acid oxidation

Autor: Arild C. Rustan, E. S. Husebye, Andreas J. Wensaas, Jon Skorve, Rune J. Ulvik, K. Løvås, Oddrun Anita Gudbrandsen, Therese H. Røst, Pavol Bohov, Rolf K. Berge

Publikováno v: Diabetes, Obesity and Metabolism. 11:304-314

Aim: We previously demonstrated that a modified fatty acid, tetradecylthioacetic acid (TTA), improves transport and utilization of lipids and increases mitochondrial fatty acid oxidation in animal and cell studies. We conducted an exploratory study o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::890275f3b66654a63469e9bd3cacd29b
https://doi.org/10.1111/j.1463-1326.2008.00958.x

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Synthesis and Analysis of Novel Glycerolipids for the Treatment of Metabolic Syndrome

Autor: Michael R. Jorgensen, Therese H. Røst, Rolf K. Berge, Melanie Müller, Jon Skorve, Kostas Kostarelos, Andrew D. Miller, Cristina Guisado, Pavol Bohov, Endre Dyrøy, Yushma Bhurruth-Alcor

Publikováno v: Journal of Medicinal Chemistry. 52:1172-1179

Tetradecylthioacetic acid (TTA) 1 is a peroxisome proliferator-activated receptor (PPAR) agonist found to improve insulin sensitivity, lower blood lipid levels, enhance fatty acid oxidation, and promote anti-inflammation in vivo. In an attempt to enh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ca938811352a9d0731d8a6a9ec54dcf
https://doi.org/10.1021/jm801019s

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Combination of fish oil and fish protein hydrolysate reduces the plasma cholesterol level with a concurrent increase in hepatic cholesterol level in high-fat–fed Wistar rats

Autor: Rolf K. Berge, Therese H. Røst, Hege Wergedahl, Oddrun Anita Gudbrandsen

Publikováno v: Nutrition. 25:98-104

Objective This study investigated the potential additive or synergistic effect of fish oil (FO) and fish protein hydrolysate (FPH) on cholesterol concentration in plasma and the liver. Methods Male Wistar rats were fed high-fat diets (30% fat, 20% pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e9d2d0b02f3771791d9633310c99d52
https://doi.org/10.1016/j.nut.2008.07.005

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Tetradecylselenoacetic Acid, a PPAR Ligand With Antioxidant, Antiinflammatory, and Hypolipidemic Properties

Autor: Thor Ueland, Endre Dyrøy, Jan Erik Nordrehaug, Pål Aukrust, Fredrik Müller, Reidar J. Pettersen, Rolf K. Berge, Ziad A. Muna, Bente Halvorsen, Oddrun Anita Gudbrandsen, Therese H. Røst

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 27:628-634

Objective— Antioxidants protect against oxidative stress and inflammation, which, in combination with hyperlipidemia, are important mediators of atherogenesis. Here we present a selenium-substituted fatty acid, tetradecylselenoacetic acid (TSA), wh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb7061b1722b93e1ccce711ac2c77052
https://doi.org/10.1161/01.atv.0000255950.70774.d5

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Antipsychotic-induced metabolic effects in the female rat: Direct comparison between long-acting injections of risperidone and olanzapine

Autor: Vidar M. Steen, Kari Merete Ersland, Silje Skrede, Rolf K. Berge, Therese H. Røst

Publikováno v: Journal of psychopharmacology (Oxford, England). 29(12)

Several antipsychotics have well-known adverse metabolic effects. Studies uncovering molecular mechanisms of such drugs in patients are challenging due to high dropout rates, previous use of antipsychotics and restricted availability of biological sa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c7edcb2ce3aeebddfabf0e36bb57199
https://pubmed.ncbi.nlm.nih.gov/26378122

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