Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Therese Cronin"'
Autor:
Jean-Baptiste Ducloyer, Virginie Pichard, Mathieu Mevel, Anne Galy, Gaelle M. Lefevre, Nicole Brument, Dimitri Alvarez-Dorta, David Deniaud, Alexandra Mendes-Madeira, Lyse Libeau, Caroline Le Guiner, Therese Cronin, Oumeya Adjali, Michel Weber, Guylène Le Meur
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 28, Iss , Pp 387-393 (2023)
The subretinal injection protocol for the only approved retinal gene therapy (voretigene neparvovec-rzyl) includes air tamponade at the end of the procedure, but its effects on the subretinal bleb have not been described. In the present study, we eva
Externí odkaz:
https://doaj.org/article/dc74dd4179c14ad388bcdc95456b14ed
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 23, p 12818 (2021)
Gene therapy (GT) for ocular disorders has advanced the most among adeno-associated virus (AAV)-mediated therapies, with one product already approved in the market. The bank of retinal gene mutations carefully compiled over 30 years, the small retina
Externí odkaz:
https://doaj.org/article/416d58a39c6649e9b4c704152ca276c3
Publikováno v:
Pharmaceuticals, Vol 5, Iss 5, Pp 447-459 (2012)
Sub-retinal injection of the common AAV2 pseudotypes frequently results in strong transduction of the retinal pigment epithelium (RPE) as well as the retina itself. This has been of benefit to date in human clinical trials using AAV, where the diseas
Externí odkaz:
https://doaj.org/article/3a5311578c3b49d1ac51dca86f92c4bc
Autor:
Aurelien Leray, Pierre-Alban Lalys, Juliette Varin, Mohammed Bouzelha, Audrey Bourdon, Dimitri Alvarez-Dorta, Karine Pavageau, Sebastien Depienne, Maia Marchand, Anthony Mellet, Joanna Demilly, Jean-Baptiste Ducloyer, Tiphaine Girard, Bodval Fraysse, Mireille Ledevin, Mickael Guilbaud, Sebastien G. Gouin, Eduard Ayuso, Oumeya Adjali, Thibaut Larcher, Therese Cronin, Caroline Le Guiner, David Deniaud, Mathieu Mevel
Decades of biological and clinical research have led to important advances in recombinant adeno-associated viruses rAAV-based gene therapy gene therapy. However, several challenges must be overcome to fully exploit the potential of rAAV vectors. Inno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33fdeaf96dcd33201a922c4fba14ec65
https://doi.org/10.26434/chemrxiv-2023-6xnn8
https://doi.org/10.26434/chemrxiv-2023-6xnn8
Autor:
C Audrain, Alexandra Mendes-Madeira, E Toublanc, L. Libeau, Carolina Isiegas, Nathalie Provost, J B Ducloyer, M Croyal, C Morival, Therese Cronin, Virginie Pichard, Oumeya Adjali
Publikováno v:
FASEB Journal
FASEB Journal, 2021, 35 (11), pp.1-17. ⟨10.1096/fj.202002525RRR⟩
FASEB Journal, 2021, 35 (11), pp.1-17. ⟨10.1096/fj.202002525RRR⟩
International audience; Dysfunction of the ATPase-binding Cassette Transporter protein (ABCA4) can lead to early onset macular degeneration, in particular to Stargardt disease. To enable translational research into this form of blindness, we evaluate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18a14aab11435485a07c1ec9832814aa
https://hal.inrae.fr/hal-03793154/document
https://hal.inrae.fr/hal-03793154/document
Publikováno v:
médecine/sciences
médecine/sciences, EDP Sciences, 2020, 36 (6-7), pp.607-615. ⟨10.1051/medsci/2020095⟩
médecine/sciences, EDP Sciences, 2020, 36 (6-7), pp.607-615. ⟨10.1051/medsci/2020095⟩
Retinitis pigmentosa is the most common blinding inherited retinal dystrophy. Gene therapy is a burgeoning revolutionary approach that paves the way to treatment of previously incurable diseases. At the end of 2017 and 2018, a gene therapy, Luxturna
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5e6bb47941a7e0d317302333277418a
https://www.hal.inserm.fr/inserm-02894145/document
https://www.hal.inserm.fr/inserm-02894145/document
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 12818, p 12818 (2021)
International Journal of Molecular Sciences, Vol 22, Iss 12818, p 12818 (2021)
Gene therapy (GT) for ocular disorders has advanced the most among adeno-associated virus (AAV)-mediated therapies, with one product already approved in the market. The bank of retinal gene mutations carefully compiled over 30 years, the small retina
Autor:
Mathieu Mével, Virginie Pichard, Mohammed Bouzelha, Dimitri Alvarez-Dorta, Pierre-Alban Lalys, Nathalie Provost, Marine Allais, Alexandra Mendes, Elodie Landagaray, Jean-Baptiste Ducloyer, Estelle Toublanc, Anne Galy, Nicole Brument, Gaëlle M. Lefevre, Sébastien G. Gouin, Carolina Isiegas, Guylène Le Meur, Thérèse Cronin, Caroline Le Guiner, Michel Weber, Philippe Moullier, Eduard Ayuso, David Deniaud, Oumeya Adjali
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 1, Pp 101187- (2024)
Inherited retinal diseases are a leading and untreatable cause of blindness and are therefore candidate diseases for gene therapy. Recombinant vectors derived from adeno-associated virus (rAAV) are currently the most promising vehicles for in vivo th
Externí odkaz:
https://doaj.org/article/1edecadd12924319b147b4cab1a426f8
Autor:
Aurélien Leray, Pierre-Alban Lalys, Juliette Varin, Mohammed Bouzelha, Audrey Bourdon, Dimitri Alvarez-Dorta, Karine Pavageau, Sébastien Depienne, Maia Marchand, Anthony Mellet, Joanna Demilly, Jean-Baptiste Ducloyer, Tiphaine Girard, Bodvaël Fraysse, Mireille Ledevin, Mickaël Guilbaud, Sébastien G. Gouin, Eduard Ayuso, Oumeya Adjali, Thibaut Larcher, Thérèse Cronin, Caroline Le Guiner, David Deniaud, Mathieu Mével
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 171, Iss , Pp 116148- (2024)
Decades of biological and clinical research have led to important advances in recombinant adeno-associated viruses rAAV-based gene therapy gene therapy. However, several challenges must be overcome to fully exploit the potential of rAAV vectors. Inno
Externí odkaz:
https://doaj.org/article/1ed978775aad41fbbbc3787da57c93b5
Autor:
Tomas S. Aleman, Pavitra S. Ramachandran, Jean Bennett, Zhangyong Wei, Ji Yun Song, Keirnan Willett, Therese Cronin, Jessica I. W. Morgan, Giulia Casal, Rachel M. Huckfeldt, Albert M. Maguire, Vivian S. Lee
Within the next decade, we will see many gene therapy clinical trials for eye diseases, which may lead to treatments for thousands of visually impaired people around the world. To target retinal diseases that affect specific cell types, several recom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2535c8401489a2356504fd62530f58ac
https://europepmc.org/articles/PMC5312498/
https://europepmc.org/articles/PMC5312498/