Zobrazeno 1 - 10
of 162
pro vyhledávání: '"Therese A, Kosten"'
Publikováno v:
Psychoactives, Vol 3, Iss 3, Pp 318-336 (2024)
Methamphetamine use disorder (MuD) is a global health problem, with no FDA-approved medications. Our prior work demonstrated that repeated methamphetamine exposure alters the gut microbiota in male rats and results in depressive-like behaviors. In th
Externí odkaz:
https://doaj.org/article/8f434dcca15443fe85a6c4f58dc3987c
Autor:
Addison E. Stone, Sarah E. Scheuermann, Colin N. Haile, Gregory D. Cuny, Marcela Lopez Velasquez, Joshua P. Linhuber, Anantha L. Duddupudi, Jennifer R. Vigliaturo, Marco Pravetoni, Therese A. Kosten, Thomas R. Kosten, Elizabeth B. Norton
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-11 (2021)
Abstract Fentanyl is a major contributor to the devastating increase in overdose deaths from substance use disorders (SUD). A vaccine targeting fentanyl could be a powerful immunotherapeutic. Here, we evaluated adjuvant and delivery strategies for co
Externí odkaz:
https://doaj.org/article/644008cc7a484a358b436c0687cf30dc
Autor:
Colin N. Haile, Miah D. Baker, Sergio A. Sanchez, Carlos A. Lopez Arteaga, Anantha L. Duddupudi, Gregory D. Cuny, Elizabeth B. Norton, Thomas R. Kosten, Therese A. Kosten
Publikováno v:
Pharmaceutics, Vol 14, Iss 11, p 2290 (2022)
Fentanyl (FEN) is a potent synthetic opioid associated with increasing incidence of opioid use disorder (OUD) and fatal opioid overdose. Vaccine immunotherapy for FEN-associated disorders may be a viable therapeutic strategy. Here, we expand and conf
Externí odkaz:
https://doaj.org/article/b87b831ac006499e8459474ee7bedd01
Autor:
Colin N. Haile, Kurt J. Varner, Xia Huijing, Reetakshi Arora, Frank M. Orson, Thomas R. Kosten, Therese A. Kosten
Publikováno v:
Vaccines, Vol 10, Iss 9, p 1508 (2022)
Background: Methamphetamine use disorder (MUD) is a growing health concern with no FDA-approved treatment. The present series of studies build upon our previous work developing an anti-methamphetamine (MA) vaccine for MUD. We determined the effects o
Externí odkaz:
https://doaj.org/article/b78660c9227a43e9b51847c33f5f5a46
Publikováno v:
Brain, Behavior, & Immunity - Health, Vol 14, Iss , Pp 100248- (2021)
Stress activates innate immune Toll-like receptors (TLRs) and enhances susceptibility to depression, a condition that is more prevalent in females. The TLR4 receptor type is involved in inflammatory responses and its expression levels associate with
Externí odkaz:
https://doaj.org/article/443992b1e5294d8b9c08916daa853c6b
Publikováno v:
The American Journal on Addictions. 30:525-538
Background and objectives A growing body of literature demonstrates that the human microbiota plays a crucial role in health and disease states, as well as in the body's response to stress. In addition, the microbiome plays a role in psychological we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81e01681bfdce02d983a425e2468b89d
https://doi.org/10.1111/ajad.13210
https://doi.org/10.1111/ajad.13210
Publikováno v:
Psychopharmacology. 238:2587-2600
Pre-clinical evidence implicates the GABAergic system in mediating the reinforcing effects of alcohol and offers a therapeutic target for alcohol use disorder (AUD). The orthosteric GABAB receptor agonist baclofen decreases alcohol self-administratio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07c0b8c66b822634aa2f25b450ff7897
https://doi.org/10.1007/s00213-021-05881-0
https://doi.org/10.1007/s00213-021-05881-0
Publikováno v:
The American Journal on Addictions. 30:358-365
BACKGROUND AND OBJECTIVES Chronic cocaine exposure has differential neural effects in Fischer 344 (F344) vs Lewis inbred rats that may explain strain-dependent differences during acquisition vs maintenance of cocaine self-administration. We assessed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0767ef87b414e5de09d72d48e767f51e
https://doi.org/10.1111/ajad.13152
https://doi.org/10.1111/ajad.13152
Publikováno v:
Brain Plasticity
Historically, most alcohol neurotoxicity studies were conducted in young adult males and focused on chronic intake. There has been a shift towards studying the effects of alcohol on the adolescent brain, due to alcohol consumption during this formati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a923bd4bbd5c5a105a23ee433982bfe
https://doi.org/10.3233/bpl-190094
https://doi.org/10.3233/bpl-190094
Publikováno v:
Psychopharmacology. 238:281-292
Methamphetamine is a highly abused psychostimulant drug and its use remains a major public health concern worldwide with limited effective treatment options. Accumulative evidence reveals the influence of gut microbiota on the brain, behavior, and he
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::52fe80c087b79788927e555ffd380756
https://doi.org/10.1007/s00213-020-05681-y
https://doi.org/10.1007/s00213-020-05681-y