Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Therese, Pham"'
Publikováno v:
Australasian Journal of Plastic Surgery, Vol 6, Iss 2 (2023)
**Background**: Skin tears cause a significant burden to the patient and healthcare system. Acute management has traditionally comprised of operative debridement and formal skin grafting, which is costly, invasive and often followed by admission for
Externí odkaz:
https://doaj.org/article/bdf711b5be24429594106771b31d0861
Autor:
Morten P. Oksvold, Ulrika Warpman Berglund, Helge Gad, Baoyan Bai, Trond Stokke, Idun Dale Rein, Therese Pham, Kumar Sanjiv, Geir Frode Øy, Jens Henrik Norum, Erlend B. Smeland, June H. Myklebust, Thomas Helleday, Thea Kristin Våtsveen
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Chemo-immunotherapy has improved survival in B-cell lymphoma patients, but refractory/relapsed diseases still represent a major challenge, urging for development of new therapeutics. Karonudib (TH1579) was developed to inhibit MTH1, an enzym
Externí odkaz:
https://doaj.org/article/2bf70b7f4423442fb0d96f1650f44291
Autor:
Xiangwei Hua, Kumar Sanjiv, Helge Gad, Therese Pham, Camilla Gokturk, Azita Rasti, Zhenjun Zhao, Kang He, Mingxuan Feng, Yunjin Zang, Jianjun Zhang, Qiang Xia, Thomas Helleday, Ulrika Warpman Berglund
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 11 (2019)
Background: Hepatocellular carcinoma (HCC) is the most common form of liver cancer and is generally caused by viral infections or consumption of mutagens, such as alcohol. While liver transplantation and hepatectomy is curative for some patients, man
Externí odkaz:
https://doaj.org/article/ea44fe1660bc4ebd9bd694a45f0ab9ba
Autor:
Nadilly Bonagas, Nina M. S. Gustafsson, Martin Henriksson, Petra Marttila, Robert Gustafsson, Elisée Wiita, Sanjay Borhade, Alanna C. Green, Karl S. A. Vallin, Antonio Sarno, Richard Svensson, Camilla Göktürk, Therese Pham, Ann-Sofie Jemth, Olga Loseva, Victoria Cookson, Nicole Kiweler, Lars Sandberg, Azita Rasti, Judith E. Unterlass, Martin Haraldsson, Yasmin Andersson, Emma R. Scaletti, Christoffer Bengtsson, Cynthia B. J. Paulin, Kumar Sanjiv, Eldar Abdurakhmanov, Linda Pudelko, Ben Kunz, Matthieu Desroses, Petar Iliev, Katarina Färnegårdh, Andreas Krämer, Neeraj Garg, Maurice Michel, Sara Häggblad, Malin Jarvius, Christina Kalderén, Amanda Bögedahl Jensen, Ingrid Almlöf, Stella Karsten, Si Min Zhang, Maria Häggblad, Anders Eriksson, Jianping Liu, Björn Glinghammar, Natalia Nekhotiaeva, Fredrik Klingegård, Tobias Koolmeister, Ulf Martens, Sabin Llona-Minguez, Ruth Moulson, Helena Nordström, Vendela Parrow, Leif Dahllund, Birger Sjöberg, Irene L. Vargas, Duy Duc Vo, Johan Wannberg, Stefan Knapp, Hans E. Krokan, Per I. Arvidsson, Martin Scobie, Johannes Meiser, Pål Stenmark, Ulrika Warpman Berglund, Evert J. Homan, Thomas Helleday
Publikováno v:
Nature Cancer
The folate metabolism enzyme MTHFD2 (methylenetetrahydrofolate dehydrogenase/cyclohydrolase) is consistently overexpressed in cancer but its roles are not fully characterized, and current candidate inhibitors have limited potency for clinical develop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebc803a4ce48681e11987b33fd0a94af
https://doi.org/10.1038/s43018-022-00331-y
https://doi.org/10.1038/s43018-022-00331-y
Autor:
Nadilly Bonagas, Nina Gustafsson, Martin Henriksson, Petra Marttila, Robert Gustafsson, Elisée Wiita, Sanjay Borhade, Alanna Green, Karl Vallin, Antonio Sarno, Richard Svensson, Camilla Göktürk, Therese Pham, Ann-Sofie Jemth, Olga Loseva, Victoria Cookson, Nicole Kiweler, Lars Sandberg, Azita Rasti, Judith Unterlass, Martin Haraldsson, Yasmin Andersson, Emma Scaletti, Christoffer Bengtsson, Cynthia Paulin, Kumar Sanjiv, Eldar Abdurakhmanov, Linda Pudelko, Ben Kunz, Matthieu Desroses, Petar Iliev, Katarina Färnegårdh, Andreas Krämer, Neeraj Garg, Maurice Michel, Sara Häggblad, Malin Jarvius, Christina Kalderén, Amanda Bögedahl Jensen, Ingrid Almlöf, Stella Karsten, Si Min Zhang, Maria Häggblad, Anders Eriksson, Jianping Liu, Björn Glinghammar, Natalia Nekhotiaeva, Fredrik Klingegård, Tobias Koolmeister, Ulf Martens, Sabin Llona-Minguez, Ruth Moulson, Helena Nordström, Vendela Parrow, Leif Dahllund, Birger Sjöberg, Irene Vargas, Duy Duc Vo, Johan Wannberg, Stefan Knapp, Hans Krokan, Per Arvidsson, Martin Scobie, Johannes Meiser, Pål Stenmark, Ulrika Warpman Berglund, Evert Homan, Thomas Helleday
Supplementary methods for the article "Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress".
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::032514cb5181fdda8fdfefd73848c5d0
https://doi.org/10.21203/rs.3.pex-1730/v1
https://doi.org/10.21203/rs.3.pex-1730/v1
Publikováno v:
International Journal of Surgery Case Reports. 95:107228
Pituitary apoplexy is a clinical syndrome that occurs secondary to abrupt haemorrhage or infarction and can cause a presentation with headache, visual disturbances, and various neurological deficits. Pituitary apoplexy is a rare clinical syndrome tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d8f6562c7a51e9629e370f1a2de725e
https://doi.org/10.1016/j.ijscr.2022.107228
https://doi.org/10.1016/j.ijscr.2022.107228
Autor:
Deepti Verma, Therese Pham, Martin Scobie, Thomas Helleday, Ulrika Warpman Berglund, Florence Sjögren, Charlotta Enerbäck, Claudia Bamberg, Ines Köhler, Stella Karsten, Cecilia Bivik Eding
Inflammatory diseases, including psoriasis, are characterized by changes in redox regulation. The MTH1 prevents the incorporation of oxidized nucleotides during DNA replication. Using MTH1 small-molecule inhibitors, we found induced apoptosis through
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7678ad44d04aa37d9e817e56401873e8
http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-179842
http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-179842
Publikováno v:
Nucleic Acids Research
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=r3c4b2081b22::1b96a4787958dae3873632e7ad65a12f
Autor:
Petra Marttila, Ingrid Almlöf, Christina Kalderén, Carolina Sandman, Björn Platzack, Stella Karsten, Ulrika Warpman Berglund, Karin Cederbrant, Xing-Mei Zhang, Robert A. Harris, Azita Rasti, Kumar Sanjiv, Lars Bräutigam, M. Marcusson-Ståhl, Therese Pham, Thomas Helleday, Roland Fiskesund
Publikováno v:
Cell Death & Differentiation
Cell Death Differ
Cell Death Differ
T cell-driven diseases account for considerable morbidity and disability globally and there is an urgent need for new targeted therapies. Both cancer cells and activated T cells have an altered redox balance, and up-regulate the DNA repair protein MT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5aa153163ae80f7ce934b6bc452148a
Autor:
Therese Pham, Kumar Sanjiv, T. Meijer, Jonas Nilsson, Christina Kalderén, Rozbeh Jafari, Fabienne Z. Gaugaz, Torkild Visnes, Annika Lindqvist, Prasad B. Wakchaure, Aleksandr Manoilov, Per Artursson, Gianluca Maddalo, U. Warpman Berglund, Olov A. Wallner, Pawel Baranczewski, V. Nagpal, Azita Rasti, Aljona Saleh, Elisee Wiita, Sean G. Rudd, Ann-Sofie Jemth, Martin Henriksson, Ingrid Almlöf, Helge Gad, Camilla Göktürk, Tobias Koolmeister, Alexey Chernobrovkin, Evert Homan, Thomas Helleday, Vassilis G. Gorgoulis, Lars Bräutigam, Berglind Osk Einarsdottir, Brinton Seashore-Ludlow, Y. Kallberg, Olga Loseva, T-C Lee, Janne Lehtiö, Sanjay R. Borhade, Björn Platzack, Patrick Herr, Anne M. Filppula, Karl S. A. Vallin, Roman A. Zubarev, Ioannis S. Pateras, Martin Scobie, Nicolaas G. M. Schipper
Publikováno v:
Annals of Oncology
Annals of oncology : official journal of the European Society for Medical Oncology
Annals of oncology : official journal of the European Society for Medical Oncology
Background: Previously we showed cancer cells rely on the MTH1 protein to prevent incorporation of otherwise deadly oxidised nucleotides into DNA and we developed MTH1 inhibitors which selectively kill cancer cells. Recently several new and potent in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0a71ea01ac7d0533472602aea288f43
https://doi.org/10.1093/annonc/mdw429
https://doi.org/10.1093/annonc/mdw429