Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Theresa Zachary"'
Autor:
Tracey Williams, Rajendran Vairagoundar, Julie A. White, Dennis L Huczek, Respondek Tomasz, Jason T. Ross, Johnson Paul D, Carolyn Hedke, Andrea J Gonzales, Govindan Subramanian, Christopher Javens, Todd Maddux, Brian A. Duclos, Theresa Zachary, Mark R Cox, Wendy Collard, Yaqi Zhu, Steven Kamerling, Scott J. Bowen
Publikováno v:
ACS Medicinal Chemistry Letters. 12:1847-1852
Human β-nerve growth factor (β-NGF) and its associated receptor, human tropomyosin receptor kinase A (hTrkA), have been demonstrated to be key factors in the perception of pain. However, efficacious small molecule therapies targeting the intracellu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b6630b824f3daa850025a3853fdae724
https://doi.org/10.1021/acsmedchemlett.1c00483
https://doi.org/10.1021/acsmedchemlett.1c00483
Autor:
Govindan, Subramanian, Brian, Duclos, Paul D, Johnson, Tracey, Williams, Jason T, Ross, Scott J, Bowen, Yaqi, Zhu, Julie A, White, Carolyn, Hedke, Dennis, Huczek, Wendy, Collard, Christopher, Javens, Rajendran, Vairagoundar, Tomasz, Respondek, Theresa, Zachary, Todd, Maddux, Mark R, Cox, Steven, Kamerling, Andrea J, Gonzales
Publikováno v:
ACS Med Chem Lett
[Image: see text] Human β-nerve growth factor (β-NGF) and its associated receptor, human tropomyosin receptor kinase A (hTrkA), have been demonstrated to be key factors in the perception of pain. However, efficacious small molecule therapies target
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fc2cffcee3fe711d396c4c194701a46f
https://pubmed.ncbi.nlm.nih.gov/34795875
https://pubmed.ncbi.nlm.nih.gov/34795875
Autor:
Govindan Subramanian, Rajendran Vairagoundar, Scott J. Bowen, Nicole Roush, Theresa Zachary, Christopher Javens, Tracey Williams, Ann Janssen, Andrea Gonzales
Publikováno v:
RSC Med Chem
In silico virtual screening followed by in vitro biochemical, biophysical, and cellular screening resulted in the identification of distinctly different hTrkA kinase domain inhibitor scaffolds. X-ray structural analysis of representative inhibitors b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3584656b859101aea2f970a4ce37378c
https://pubmed.ncbi.nlm.nih.gov/33479642
https://pubmed.ncbi.nlm.nih.gov/33479642
Autor:
Julie A. White, Andrea J Gonzales, Tracey Williams, Ann Janssen, Theresa Zachary, Dennis L Huczek, Scott J. Bowen, Govindan Subramanian, Yaqi Zhu, Christopher Javens, Nicole Roush
Publikováno v:
Bioorganicmedicinal chemistry letters. 29(22)
Virtual in silico structure-guided modeling, followed by in vitro biochemical screening of a subset of commercially purchasable compound collection resulted in the identification of several human tropomyosin receptor kinase A (hTrkA) inhibitors that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be2e40af679acf04c5fe28464d5fde08
https://pubmed.ncbi.nlm.nih.gov/31610943
https://pubmed.ncbi.nlm.nih.gov/31610943
Autor:
Andrea J Gonzales, Nicole Roush, Ann Janssen, Tracey Williams, Scott J. Bowen, Yaqi Zhu, Theresa Zachary, Christopher Javens, Govindan Subramanian
Publikováno v:
Bioorganicmedicinal chemistry letters. 29(19)
In silico virtual screening using the ligand-based ROCS approach and the commercially purchasable compound collection from the ZINC database resulted in the identification of distinctly different and novel acetamide core frameworks with series repres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf970bb15732e6187610487e48a06264
https://pubmed.ncbi.nlm.nih.gov/31444087
https://pubmed.ncbi.nlm.nih.gov/31444087
Autor:
Govindan Subramanian, Paul D. Johnson, Theresa Zachary, Nicole Roush, Yaqi Zhu, Scott J. Bowen, Ann Janssen, Brian A. Duclos, Tracey Williams, Christopher Javens, Nancy Dekki Shalaly, Daniel Martinez Molina, Arthur J. Wittwer, Jeffrey L. Hirsch
Publikováno v:
ACS chemical biology. 14(6)
Access to cryptic binding pockets or allosteric sites on a kinase that present themselves when the enzyme is in a specific conformational state offers a paradigm shift in designing the next generation small molecule kinase inhibitors. The current wor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a0edc89000af4461790f75c6c7f1c9f
https://pubmed.ncbi.nlm.nih.gov/31059222
https://pubmed.ncbi.nlm.nih.gov/31059222