Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Theresa Stauss"'
Autor:
Sharyn Thomas, Fiyaz Mohammed, Rogier M. Reijmers, Annemarie Woolston, Theresa Stauss, Alan Kennedy, David Stirling, Angelika Holler, Louisa Green, David Jones, Katherine K. Matthews, David A. Price, Benjamin M. Chain, Mirjam H. M. Heemskerk, Emma C. Morris, Benjamin E. Willcox, Hans J. Stauss
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Increasing TCR cell surface expression can potentiate T cell responses to low-concentrations of antigen. Here the authors identify aminoacids in human TCR variable domains that impact its surface expression, and demonstrate how editing these residues
Externí odkaz:
https://doaj.org/article/b91ffe9fd06f4dd8ae5b0aa7c12c5d8e
Autor:
David Price, Fiyaz Mohammed, Benjamin E. Willcox, Louisa Green, Emma C. Morris, David Stirling, Rogier M. Reijmers, Theresa Stauss, Hans J. Stauss, Angelika Holler, Benjamin M. Chain, Sharyn Thomas, Katherine K. Matthews, Alan Kennedy, Mirjam H.M. Heemskerk, Annemarie Woolston, David T. Jones
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications, 10
Nature Communications
Nature Communications, 10
Nature Communications
TCR-gene-transfer is an efficient strategy to produce therapeutic T cells of defined antigen specificity. However, there are substantial variations in the cell surface expression levels of human TCRs, which can impair the function of engineered T cel