Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Theresa Proia"'
Autor:
Anna D. Staniszewska, Joshua Armenia, Matthew King, Chrysiis Michaloglou, Avinash Reddy, Maneesh Singh, Maryann San Martin, Laura Prickett, Zena Wilson, Theresa Proia, Deanna Russell, Morgan Thomas, Oona Delpuech, Mark J. O’Connor, Elisabetta Leo, Helen Angell, Viia Valge-Archer
Publikováno v:
OncoImmunology, Vol 11, Iss 1 (2022)
PARP inhibitors are synthetically lethal with BRCA1/2 mutations, and in this setting, accumulation of DNA damage leads to cell death. Because increased DNA damage and subsequent immune activation can prime an anti-tumor immune response, we studied th
Externí odkaz:
https://doaj.org/article/42e14e70567c4dc0ac16e7566635a844
Autor:
Matthew J. Sale, Emma Minihane, Noel R. Monks, Rebecca Gilley, Frances M. Richards, Kevin P. Schifferli, Courtney L. Andersen, Emma J. Davies, Mario Aladren Vicente, Eiko Ozono, Aleksandra Markovets, Jonathan R. Dry, Lisa Drew, Vikki Flemington, Theresa Proia, Duncan I. Jodrell, Paul D. Smith, Simon J. Cook
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
BRAF or MEK1/2 inhibitors are cytostatic in melanoma and the surviving cells develop drug resistance. This study shows that the pro-survival pool is biased towards MCL1 in melanoma so that BRAF or MEK1/2 inhibitors are synthetic lethal with the MCL1
Externí odkaz:
https://doaj.org/article/03dfbb8e162440b8bfec0b14545e606c
Autor:
Sarah Phillips, Aleix Prat, Maja Sedic, Theresa Proia, Ania Wronski, Sohini Mazumdar, Adam Skibinski, Stephanie H. Shirley, Charles M. Perou, Grace Gill, Piyush B. Gupta, Charlotte Kuperwasser
Publikováno v:
Stem Cell Reports, Vol 2, Iss 5, Pp 633-647 (2014)
Perturbations in stem cell activity and differentiation can lead to developmental defects and cancer. We use an approach involving a quantitative model of cell-state transitions in vitro to gain insights into how SLUG/SNAI2, a key developmental trans
Externí odkaz:
https://doaj.org/article/49bf3ae918ff4bb49ce7180791cc9d2e
Autor:
Heidi Okamura, Jeno Gyuris, Jie Lin, Ronan O'Hagan, Samantha Perino, Solly Weiler, Meghan Flaherty, William M. Winston, Laura Poling, Kelly Kreuter, Lingxin Kong, Richard Nicoletti, Alisa Bell, Feng Jiang, Theresa Proia
Supplementary Figure Legends. Figure legends for supplementary figures S1, S2, S3 and table S1.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78b1fd73bd78c98e763d17e4b0b22b8b
https://doi.org/10.1158/1535-7163.22502494
https://doi.org/10.1158/1535-7163.22502494
Autor:
Heidi Okamura, Jeno Gyuris, Jie Lin, Ronan O'Hagan, Samantha Perino, Solly Weiler, Meghan Flaherty, William M. Winston, Laura Poling, Kelly Kreuter, Lingxin Kong, Richard Nicoletti, Alisa Bell, Feng Jiang, Theresa Proia
Supplementary Materials and Methods. Description of Materials and Methods for experiments in supplementary data.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13138cd31ee3536d99c444efc4345d30
https://doi.org/10.1158/1535-7163.22502485.v1
https://doi.org/10.1158/1535-7163.22502485.v1
Autor:
Heidi Okamura, Jeno Gyuris, Jie Lin, Ronan O'Hagan, Samantha Perino, Solly Weiler, Meghan Flaherty, William M. Winston, Laura Poling, Kelly Kreuter, Lingxin Kong, Richard Nicoletti, Alisa Bell, Feng Jiang, Theresa Proia
Supplementary Figures S1-3 and Table S1. Supplementary Figure S1: Histopathology and 23814 Serum Concentration at end of toxicity study Supplementary Figure S2: 23814 Treatment Increases Vasculature Even in Tumors with Limited Response Supplementary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b517f8fc5d4c2134f8ae9c3550c2be66
https://doi.org/10.1158/1535-7163.22502488
https://doi.org/10.1158/1535-7163.22502488
Autor:
Lisa Drew, Stephen E. Fawell, Michael Zinda, David M. Weinstock, Raphael Koch, Jamal C. Saeh, Wenlin Shao, Clive S. D'Santos, Chandra Sekhar Reddy Chilamakuri, Valar Nila Roamio Franklin, Nancy Su, Petar Pop-Damkov, Maryann San Martin, Steven W. Criscione, Douglas Ferguson, Theresa Proia, Scott Boiko, Justin Cidado
Purpose:Cyclin-dependent kinase 9 (CDK9) is a transcriptional regulator and potential therapeutic target for many cancers. Multiple nonselective CDK9 inhibitors have progressed clinically but were limited by a narrow therapeutic window. This work des
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e78a2f9d8bc4116c23d641a6d2430c69
https://doi.org/10.1158/1078-0432.c.6528438
https://doi.org/10.1158/1078-0432.c.6528438
Autor:
Lisa Drew, Stephen E. Fawell, Michael Zinda, David M. Weinstock, Raphael Koch, Jamal C. Saeh, Wenlin Shao, Clive S. D'Santos, Chandra Sekhar Reddy Chilamakuri, Valar Nila Roamio Franklin, Nancy Su, Petar Pop-Damkov, Maryann San Martin, Steven W. Criscione, Douglas Ferguson, Theresa Proia, Scott Boiko, Justin Cidado
Material, methods, supplementary references, and list of supplementary tables.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::452c2d4f2e72a9f64fb946ec7fddeb69
https://doi.org/10.1158/1078-0432.22473192
https://doi.org/10.1158/1078-0432.22473192
Autor:
Lisa Drew, Stephen E. Fawell, Michael Zinda, David M. Weinstock, Raphael Koch, Jamal C. Saeh, Wenlin Shao, Clive S. D'Santos, Chandra Sekhar Reddy Chilamakuri, Valar Nila Roamio Franklin, Nancy Su, Petar Pop-Damkov, Maryann San Martin, Steven W. Criscione, Douglas Ferguson, Theresa Proia, Scott Boiko, Justin Cidado
Identification of highly selective and potent CDK9 inhibitor, AZD4573.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84e366b0dc227f1d2ebf32c454d70b9e
https://doi.org/10.1158/1078-0432.22473207.v1
https://doi.org/10.1158/1078-0432.22473207.v1
Autor:
Lisa Drew, Stephen E. Fawell, Michael Zinda, David M. Weinstock, Raphael Koch, Jamal C. Saeh, Wenlin Shao, Clive S. D'Santos, Chandra Sekhar Reddy Chilamakuri, Valar Nila Roamio Franklin, Nancy Su, Petar Pop-Damkov, Maryann San Martin, Steven W. Criscione, Douglas Ferguson, Theresa Proia, Scott Boiko, Justin Cidado
List of antibodies (S1), PK/PD/efficacy model parameters (S2), putative cancer-associated genes (S3), and transcripts modulated by AZD4573 (S4).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c9d91db0a50ac30baa8045d2a585387
https://doi.org/10.1158/1078-0432.22473189.v1
https://doi.org/10.1158/1078-0432.22473189.v1