Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Theresa Mulholland"'
Autor:
Caroline Busch, Theresa Mulholland, Michele Zagnoni, Matthew Dalby, Catherine Berry, Helen Wheadon
Publikováno v:
Cell Communication and Signaling, Vol 21, Iss 1, Pp 1-17 (2023)
Abstract Background Despite improved patient outcome using tyrosine kinase inhibitors (TKIs), chronic myeloid leukaemia (CML) patients require life-long treatment due to leukaemic stem cell (LSC) persistence. LSCs reside in the bone marrow (BM) niche
Externí odkaz:
https://doaj.org/article/fbe6d5d0bb3447628508594bc360d398
Publikováno v:
IEEE Open Journal of Engineering in Medicine and Biology, Vol 3, Pp 86-95 (2022)
Chimeric antigen receptor (CAR)-T cell therapy is efficacious against many haematological malignancies, but challenges remain when using this cellular immunotherapy for treating solid tumours. Classical 2D in vitro models fail to recapitulate the com
Externí odkaz:
https://doaj.org/article/eaba4ea35d8546e281cfac93783da60e
Autor:
David J. Flint, Mark A. Underwood, Theresa Mulholland, Samantha Patek, Joanne Edwards, Milly J. McAllister, Alexander Sim, Michele Zagnoni
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Performing drug screening of tissue derived from cancer patient biopsies using physiologically relevant 3D tumour models presents challenges due to the limited amount of available cell material. Here, we present a microfluidic platform that enables d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2503128ecb65a01a77648f96d5d526e3
https://strathprints.strath.ac.uk/65509/8/Mulholland_etal_SR_2018_Drug_screening_of_biopsy_derived_spheroids_using_a_self_generated_microfluidic.pdf
https://strathprints.strath.ac.uk/65509/8/Mulholland_etal_SR_2018_Drug_screening_of_biopsy_derived_spheroids_using_a_self_generated_microfluidic.pdf
Autor:
Chloe Gulliver, Catherine C. Berry, Helen Wheadon, Caroline Busch, Theresa Mulholland, Michele Zagnoni
Publikováno v:
Blood. 134:3732-3732
Despite improved patient outcome using tyrosine kinase inhibitors (TKIs), chronic myeloid leukemia (CML) patients require life-long treatment due to leukemic stem cell (LSC) persistence. LSCs reside together with mesenchymal stem cells (MSCs) and hem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::766bee669adb43a9ad74670bffebb1d5
https://doi.org/10.1182/blood-2019-123967
https://doi.org/10.1182/blood-2019-123967
Autor:
Michele Zagnoni, Alexander Sim, Mark A. Underwood, Joanne Edwards, Samantha Patek, Milly J. McAllister, David J. Flint, Theresa Mulholland
Publikováno v:
Cancer Research. 78:5024-5024
Performing drug screening, of physiologically relevant three-dimensional (3D) tumor models, for personalized treatment remains challenging, due to the small amount of tissue available from most biopsies. New microfluidic technologies, enabling greate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b034955b2654f74a9280af38444821ff
https://doi.org/10.1158/1538-7445.am2018-5024
https://doi.org/10.1158/1538-7445.am2018-5024