Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Theresa M. Ward"'
Autor:
Sarah J. Mitchell, Alejandro Martin-Montalvo, Evi M. Mercken, Hector H. Palacios, Theresa M. Ward, Gelareh Abulwerdi, Robin K. Minor, George P. Vlasuk, James L. Ellis, David A. Sinclair, John Dawson, David B. Allison, Yongqing Zhang, Kevin G. Becker, Michel Bernier, Rafael de Cabo
Publikováno v:
Cell Reports, Vol 6, Iss 5, Pp 836-843 (2014)
The prevention or delay of the onset of age-related diseases prolongs survival and improves quality of life while reducing the burden on the health care system. Activation of sirtuin 1 (SIRT1), an NAD+-dependent deacetylase, improves metabolism and c
Externí odkaz:
https://doaj.org/article/4311e779c1b84073a91f71df14820ee9
Autor:
Jordan J Licata, Robin K. Minor, Gelareh Abulwerdi, Christoph H. Westphal, Theresa M. Ward, James L. Ellis, Hector H. Palacios, David A. Sinclair, Peter J. Elliott, Sarah J. Mitchell, Michel Bernier, Rafael de Cabo, Nathan L. Price, Dushani L. Palliyaguru
Publikováno v:
J Gerontol A Biol Sci Med Sci
SRT1720, a sirtuin1-activator, and metformin (MET), an antidiabetic drug, confer health and life-span benefits when administered individually. It is unclear whether combination of the two compounds could lead to additional benefits. Groups of 56-week
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f14201f16e0be1fc5483b12b70349c1b
https://pubmed.ncbi.nlm.nih.gov/32556267
https://pubmed.ncbi.nlm.nih.gov/32556267
Autor:
Alberto Diaz-Ruiz, Andrea Di Francesco, Michel Bernier, Theresa M. Ward, Sophia R. Levan, Rafael de Cabo, Evi M. Mercken, Kevin J. Pearson, Nathan L. Price, Bethany A. Carboneau
Publikováno v:
The Journals of Gerontology: Series A. 74:155-162
Caloric restriction (CR) is the most potent nonpharmacological intervention known to both protect against carcinogenesis and delay aging in laboratory animals. There is a growing number of anticarcinogens and CR mimetics that activate NAD(P)H:quinone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::823f93dca61f4f3517e15612e9a5af0e
https://doi.org/10.1093/gerona/gly112
https://doi.org/10.1093/gerona/gly112
Publikováno v:
Visual Journal of Emergency Medicine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d77dfc3b3fe73fe79837d21a45e5ec0d
https://doi.org/10.1016/j.visj.2020.100796
https://doi.org/10.1016/j.visj.2020.100796
Autor:
Ahmed Ali, Miguel Calvo-Rubio, R. Michael Anson, T. Mark Beasley, Vincent Guiterrez, John Dawson, Vilhelm A. Bohr, Pinchas Cohen, Devin Wahl, Dan L. Longo, Ana Maria Cuervo, David W. Frederick, Rafael de Cabo, M. I. Burón, Yongqing Zhang, Joseph A. Baur, Donald K. Ingram, Kevin J. Pearson, James R. Mitchell, José A. González-Reyes, Evandro Fei Fang, José M. Villalba, Christopher Hine, Julio Madrigal-Matute, Kevin G. Becker, Morten Scheibye-Knudsen, Gene B. Hubbard, Yuji Ikeno, Marta Gonzalez-Freire, Michel Bernier, Sarah J. Mitchell, Frank Madeo, Lukas Habering, David B. Allison, Susmita Kaushik, Junxiang Wan, Theresa M. Ward, Josephine M. Egan, Bindi Patel, Miguel A. Aon, Sonia Cortassa, Huan Cai, Plácido Navas, Luigi Ferrucci, David A. Sinclair, Hector H. Palacios, Filomena Broeskamp
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
Author manuscript; available in PMC 2017 June 14.-- et al.
Calorie restriction (CR) is the most robust non-genetic intervention to delay aging. However, there are a number of emerging experimental variables that alter CR responses. We investigat
Calorie restriction (CR) is the most robust non-genetic intervention to delay aging. However, there are a number of emerging experimental variables that alter CR responses. We investigat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d758f9f5688dc7e65e1d3366a5535f6e
https://pubmed.ncbi.nlm.nih.gov/27304509
https://pubmed.ncbi.nlm.nih.gov/27304509
Autor:
Johan Auwerx, Yongqing Zhang, Carles Cantó, Melissa Krawczyk, David A. Sinclair, Christoph H. Westphal, George P. Vlasuk, Elin Lehrmann, Evi M. Mercken, Kevin G. Becker, Joseph A. Baur, Zoltan Ungvari, Morten Scheibye-Knudsen, Rafael de Cabo, Myriam Gorospe, William R. Swindell, Josephine M. Egan, Nathan L. Price, Basil P. Hubbard, Peter J. Elliott, Robin K. Minor, Theresa M. Ward, Alexa A. White, James L. Ellis, Kotb Abdelmohsen, Pablo M. Irusta, Vilhelm A. Bohr, Mark I. Talan, Yu Kyong Shin, Ana P. Gomes, Anna Csiszar, Alejandro Martin-Montalvo, Kevin J. Pearson
Publikováno v:
Scientific Reports. 3
Sirt1 is an NAD+-dependent deacetylase that extends lifespan in lower organisms and improves metabolism and delays the onset of age-related diseases in mammals. Here we show that SRT1720, a synthetic compound that was identified for its ability to ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4ddbc2a1bae593c4876f2130bdfaf74
https://doi.org/10.1038/srep01131
https://doi.org/10.1038/srep01131
Autor:
Edward M. Tilmont, Josephine M. Egan, Mitesh Sanghvi, María M. Malagón, Christopher H. Morrell, Plácido Navas, Caitlin M. Younts, Yolanda Jimenez-Gomez, Theresa M. Ward, Jonathan S. Bogan, Kaitlyn N. Lewis, Joanne S. Allard, Julie A. Mattison, Luigi Ferrucci, Alex M. Sossong, Richard Herbert, Joseph A. Baur, Dan L. Longo, Ruin Moaddel, Rafael de Cabo, Alejandro Martin-Montalvo, Kevin J. Pearson, Michel Bernier, Jonathan P. Belman, Hector H. Palacios
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
PMID:24093677.-- et al.
Obesity is associated with a chronic, low-grade, systemic inflammation that may contribute to the development of insulin resistance and type 2 diabetes. Resveratrol, a natural compound with anti-inflammatory properties, i
Obesity is associated with a chronic, low-grade, systemic inflammation that may contribute to the development of insulin resistance and type 2 diabetes. Resveratrol, a natural compound with anti-inflammatory properties, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5af1f7769e7d87ab243d9dcb1541b0b8
http://hdl.handle.net/10261/129202
http://hdl.handle.net/10261/129202
The societal impact of obesity, diabetes, and other metabolic disorders continues to rise despite increasing evidence of their negative long-term consequences on health span, longevity, and aging. Unfortunately, dietary management and exercise freque
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ae8831457aaf3a9cfcd09573b04bf0e
https://europepmc.org/articles/PMC2884086/
https://europepmc.org/articles/PMC2884086/
Autor:
Martha Kaufman, Theresa M Ward, Rodney Guerra, David C. Riley, Yesenia Acevedo, Adenike Folorunsho
Publikováno v:
Critical Ultrasound Journal
A 45-year-old woman presented to the emergency department with a 2-day history of severe left shoulder pain made worse with movement. Emergency department (ED) bedside point-of-care static and dynamic ultrasound examination of the supraspinatus tendo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2725b2aa5ad696f69108a6b3ca118cc8
http://europepmc.org/articles/PMC3675373
http://europepmc.org/articles/PMC3675373
Autor:
Patricia L. Mote, Ana P. Gomes, Yinbing Yu, Vilhelm A. Bohr, Alejandro Martin-Montalvo, Kevin G. Becker, Evi M. Mercken, Robin K. Minor, Yongqing Zhang, Sarah J. Mitchell, Hector H. Palacios, Matthias Schwab, Donald K. Ingram, Michael Pollak, Theresa M. Ward, Norman S. Wolf, David A. Sinclair, Morten Scheibye-Knudsen, Stephen R. Spindler, Michel Bernier, Rafael de Cabo, Marie-José Blouin
Publikováno v:
Nature communications
Metformin is a drug commonly prescribed to treat patients with type 2 diabetes. Here we show that long-term treatment with metformin (0.1% w/w in diet) starting at middle age extends healthspan and lifespan in male mice, while a higher dose (1% w/w)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a221c5797640517bbfd7bca3507039b9
http://europepmc.org/articles/PMC3736576
http://europepmc.org/articles/PMC3736576