Zobrazeno 1 - 10
of 98
pro vyhledávání: '"Theresa Link"'
Autor:
Volker Möbus, Hans-Joachim Lück, Ekkehart Ladda, Peter Klare, Knut Engels, Marcus Schmidt, Andreas Schneeweiss, Eva-Maria Grischke, Grischa Wachsmann, Helmut Forstbauer, Michael Untch, Frederik Marmé, Jens-Uwe Blohmer, Christian Jackisch, Jens Huober, Elmar Stickeler, Mattea Reinisch, Theresa Link, Bruno Sinn, Wolfgang Janni, Carsten Denkert, Sabine Seiler, Christine Solbach, Sabine Schmatloch, Julia Rey, Sibylle Loibl
Publikováno v:
npj Breast Cancer, Vol 10, Iss 1, Pp 1-10 (2024)
Abstract GAIN-2 trial evaluated the optimal intense dose-dense (idd) strategy for high-risk early breast cancer. This study reports the secondary endpoints pathological complete response (pCR) and overall survival (OS). Patients (n = 2887) were rando
Externí odkaz:
https://doaj.org/article/b93eb5cc3e364be681372848cc75b63c
Autor:
Jens Huober, Marion van Mackelenbergh, Andreas Schneeweiss, Fenja Seither, Jens-Uwe Blohmer, Carsten Denkert, Hans Tesch, Claus Hanusch, Christoph Salat, Kerstin Rhiem, Christine Solbach, Peter A. Fasching, Christian Jackisch, Mattea Reinisch, Bianca Lederer, Keyur Mehta, Theresa Link, Valentina Nekljudova, Sibylle Loibl, Michael Untch
Publikováno v:
npj Breast Cancer, Vol 9, Iss 1, Pp 1-12 (2023)
Abstract This retrospective pooled analysis aims to identify factors predicting relapse despite a pathologic complete response (pCR) in patients with breast cancer (BC). 2066 patients with a pCR from five neoadjuvant GBG/AGO-B trials fulfill the incl
Externí odkaz:
https://doaj.org/article/1894262e05954747a7b2989d697dd085
Autor:
Pauline Wimberger, Jens-Uwe Blohmer, Petra Krabisch, Theresa Link, Marianne Just, Bruno Valentin Sinn, Eike Simon, Christine Solbach, Tanja Fehm, Carsten Denkert, Cristin Kühn, Kerstin Rhiem, Hans Tesch, Sherko Kümmel, Andrea Petzold, Oliver Stötzer, Cornelia Meisel, Jan Dominik Kuhlmann, Valentina Nekljudova, Sibylle Loibl
Publikováno v:
Breast Cancer Research, Vol 25, Iss 1, Pp 1-9 (2023)
Abstract Background Disseminated tumor cells (DTCs) in the bone marrow are observed in about 40% at primary diagnosis of breast cancer and predict poor survival. While anti-resorptive therapy with bisphosphonates was shown to eradicate minimal residu
Externí odkaz:
https://doaj.org/article/eb954369b30944128d75b1da2edd9bd4
Autor:
Hannah Woopen, Maren Keller, Dario Zocholl, Suzana Mittelstadt, Maria-Pilar Barretina-Ginesta, Viola Heinzelmann-Schwarz, Judith Lafleur, Roman Kocián, Joanna Baum, Petra Krabisch, Patriciu Achimas-Cadariu, Mehmet Ali Vardar, Ignace Vergote, Sara Nasser, Theresa Link, Marta Gil-Martin, Tibor A. Zwimpfer, Katharina Leitner, Marcin Jedryka, Tamara Boxler, Elena Ioana Braicu, Jalid Sehouli
Publikováno v:
Cancers, Vol 15, Iss 22, p 5428 (2023)
The aim of this survey was to increase the knowledge on the characteristics and health concerns of long-term survivors (LTS; survival > 5 years) after ovarian cancer in order to tailor follow-up care. This international survey was initiated by the NO
Externí odkaz:
https://doaj.org/article/d98f68e3c8d14062be7db5985a925ff8
Autor:
Claudia Arndt, Antje Tunger, Rebekka Wehner, Rebecca Rothe, Eleni Kourtellari, Stephanie Luttosch, Katharina Hannemann, Stefanie Koristka, Liliana R. Loureiro, Anja Feldmann, Torsten Tonn, Theresa Link, Jan Dominik Kuhlmann, Pauline Wimberger, Michael Philipp Bachmann, Marc Schmitz
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
The cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitor palbociclib is an emerging cancer therapeutic that just recently gained Food and Drug Administration approval for treatment of estrogen receptor (ER)-positive, human epidermal growth factor recep
Externí odkaz:
https://doaj.org/article/d050e2b4207a49ff823ba99d4383286d
Publikováno v:
Molecular Oncology, Vol 15, Iss 12, Pp 3626-3638 (2021)
The pleiotropic protein hepatocyte growth factor (HGF) is the only known ligand of the tyrosine kinase mesenchymal–epithelial transition (cMET) receptor. The HGF/cMET pathway mediates invasion and migration of ovarian cancer cells, and upregulation
Externí odkaz:
https://doaj.org/article/cf6cb568631c407b9309e6601d063dd2
Publikováno v:
Molecular Oncology, Vol 15, Iss 9, Pp 2491-2503 (2021)
The tyrosine kinase mesenchymal–epithelial transition (cMET) is typically overexpressed in up to 75% of patients with ovarian cancer, and cMET overexpression has been associated with poor prognosis. The proteolytic release of the soluble cMET (sMET
Externí odkaz:
https://doaj.org/article/6da9b1be43eb481283f9213407d52cce
Autor:
Daniel Martin Klotz, Jan Dominik Kuhlmann, Theresa Link, Maren Goeckenjan, Lorenz C. Hofbauer, Andy Göbel, Tilman D. Rachner, Pauline Wimberger
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
BackgroundNeuropilin (NRP) is a transmembrane protein, which has been shown to be a pro-angiogenic mediator and implicated as a potential driver of cancer progression. NRP-1 up-regulation in ovarian cancer tissue predicts poor prognosis. However, the
Externí odkaz:
https://doaj.org/article/03ee71a135cd4b958849b2d257f515b6
Establishment and Molecular Characterization of an In Vitro Model for PARPi-Resistant Ovarian Cancer
Autor:
Daniel Martin Klotz, Franziska Maria Schwarz, Anna Dubrovska, Kati Schuster, Mirko Theis, Alexander Krüger, Oliver Kutz, Theresa Link, Pauline Wimberger, Stephan Drukewitz, Frank Buchholz, Jürgen Thomale, Jan Dominik Kuhlmann
Publikováno v:
Cancers, Vol 15, Iss 15, p 3774 (2023)
Overcoming PARPi resistance is a high clinical priority. We established and characterized comparative in vitro models of acquired PARPi resistance, derived from either a BRCA1-proficient or BRCA1-deficient isogenic background by long-term exposure to
Externí odkaz:
https://doaj.org/article/652e57059efa460abfe8a58b54b2fe5a
Autor:
Theresa Link, Jan Dominik Kuhlmann, Dennis Kobelt, Pia Herrmann, Yana D. Vassileva, Michael Kramer, Kerstin Frank, Maren Göckenjan, Pauline Wimberger, Ulrike Stein
Publikováno v:
Molecular Oncology, Vol 13, Iss 5, Pp 1268-1279 (2019)
Metastasis‐associated in colon cancer 1 (MACC1) and S100 calcium‐binding protein A4 (S100A4) are prominent inducers of tumor progression and metastasis. For the first time, we systematically tracked circulating serum levels of MACC1 and S100A4 tr
Externí odkaz:
https://doaj.org/article/632101c2f99147fa83dc82928d3ecaeb