Comparative risk of major congenital malformations with eight different antiepileptic drugs: a prospective cohort study of the EURAP registry

Autor: Birgitte Forsom Sondal, Zarouhi Hertz, Brenda Diputado, Meritxell Martinez Ferri, Odo Hildenhagen, Aldo Paggi, Gerhard Luef, Jakob Christensen, John Craig, Jana Zárubová, Gordana Kiteva-Trencevska, Raffaele Rocchi, Erik Tauboll, Lisa Gordon, Terttu Heikinheimo-Connell, Uden Navn, Ketevan Khomeriki, Iva Marečková, Erminio Bonizzoni, Michela Cecconi, Lone Rodam, Astrid Carius, Ineke Hogenesch, Katarzyna Miesczanleh, Angelo Labate, Eva Kumlien, Claus Albretsen, Torbjörn Tomson, Chiara Pantaleoni, David Sopelana Garay, Albertina Franza, Imad Halawa, Stefan Juhl, Emilio Perucca, Pia Gellert, Daniela Marino, Aline Russell, E. Kluck, Eylert Brodtkorb, Luigi Maria Specchio, Isabel Pires, Pietro Pignatta, Frank J.E. Vajda, Anette Huuse Farmen, Hans Lindsten, Boštjan Čebular, Maria Paola Canevini, Jens Arentsen, Francesca Faravelli, Bettina Schmitz, Noémi Becser Andersen, Birgit Müffelmann, Petr Bušek, T.-Y. Chang, Alma Sikiric, Judith Osseforth, Elias Zakharia, Elsebeth Bruun Christensen, Gemma Sansa Fayos, Vaiva Petrenaite, Alessandra Pistelli, Eliana Pastor, Hana Krijtová, Tim Hendgen, Leonor Cabral-Lim, Marina Trivisano, Hsiang-Yu Yu, Renata Listonova, Torleiv Svendsen, Vladimír Safcák, Nicoletta Foschi, Kristina Malmgren, Reetta Kälviäinen, Dag Aurlien, Martin J. Brodie, Maria Dolores Castro Vilanova, Anders Nilsson, Jesús Antonio Riuz Gimenez, Christian Samsonsen, Katsuyuki Fukushima, Maria Strandberg, Masaaki Kato, Giovanni De Maria, Katrine Haggag, Anna Maija Saukkonen, Maja Milovanovic, Masahiro Mizobuchi, Peter Mattsson, Bernhard Oehl, Anne Sabers, Juan Luis Becerra Cuñat, Mogens Worm, Antonio Gambardella, Miri Neufeld, Reina Roivainen, Kiyohito Terada, Janne Marit Ertresvåg, Birthe Pedersen, Gisela Rytířová, Claudia Cagnetti, Sanjeev V Thomas, Dick Lindhout, Silvia Kochen, Katherine Turner, Dieter Dennig, Luisa Antonini, Dina Battino, Laura Broglio, Aileen McGonigal, Helena Gauffin, Andrea Ortenzi, Ismael Barzinji, Hideyuki Ohtani, Rasmus Lossius, Elisabeth Robert-Gnansia, Morteza Zarifi-Oskoie, Leif Gjerstad, Barbara Tettenborn, Stephanie Hödl, Martin Kurthen, Barbara Mostacci, Alejandro De Marinis, Natalia Bohorquez Morera, Karl O. Nakken, Yushi Inoue, Germaine Kenou Van Rijckevorssel, Theresa Lasch, Iñigo Garamendi Ruiz, Silje Alvestad, Eugène van Puijenbroek, Anders Lundgren, Elena Zambrelli, Toni Escartin, Bernhard J. Steinhoff, Dominique Flügel

Publikováno v: Lancet Neurology, 17(6), 530-538. ELSEVIER SCIENCE INC
Christensen, J, Brændgaard, H & EURAP Study Group 2018, ' Comparative risk of major congenital malformations with eight different antiepileptic drugs: a prospective cohort study of the EURAP registry ', Lancet Neurology, vol. 17, no. 6, pp. 530-538 . https://doi.org/10.1016/S1474-4422(18)30107-8
Epilepsy Currents
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Background: Evidence for the comparative teratogenic risk of antiepileptic drugs is insufficient, particularly in relation to the dosage used. Therefore, we aimed to compare the occurrence of major congenital malformations following prenatal exposure

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https://research.rug.nl/en/publications/e1ac6454-26ab-449f-b9d3-ded61fad6250