Zobrazeno 1 - 10
of 237
pro vyhledávání: '"Theresa L Powell"'
Autor:
Elena Silva, Véronique Ferchaud‐Roucher, Anita Kramer, Lana Madi, Priyadarshini Pantham, Stephanie Chassen, Thomas Jansson, Theresa L. Powell
Publikováno v:
FASEB BioAdvances, Vol 6, Iss 1, Pp 1-11 (2024)
Abstract Normal fetal development is critically dependent on optimal nutrient supply by the placenta, and placental amino acid transport has been demonstrated to be positively associated with fetal growth. Mechanistic target of rapamycin (mTOR) is a
Externí odkaz:
https://doaj.org/article/6adb0c403a7a455989befc49335ab12d
Autor:
Theresa L. Powell, Charis Uhlson, Lana Madi, Karin Zemski Berry, Stephanie S. Chassen, Thomas Jansson, Veronique Ferchaud-Roucher
Publikováno v:
Biology of Sex Differences, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Background We have previously reported that maternal obesity reduces placental transport capacity for lysophosphatidylcholine-docosahexaenoic acid (LPC-DHA), a preferred form for transfer of DHA (omega 3) to the fetal brain, but only in male
Externí odkaz:
https://doaj.org/article/90af4703a2e24a91bfbc4fa598ec7402
Autor:
Amy Kelly, Jeannie Chan, Theresa L. Powell, Laura A. Cox, Thomas Jansson, Fredrick J. Rosario
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Infants born to obese mothers have an increased risk of developing obesity and metabolic diseases in childhood and adulthood. Although the molecular mechanisms linking maternal obesity during pregnancy to the development of metabolic diseases in offs
Externí odkaz:
https://doaj.org/article/e81e6aa845b44b9fbe11dab68f712d74
Autor:
Maren-Helene Langeland Degnes, Ane Cecilie Westerberg, Manuela Zucknick, Theresa L. Powell, Thomas Jansson, Tore Henriksen, Marie Cecilie Paasche Roland, Trond Melbye Michelsen
Publikováno v:
BMC Medicine, Vol 20, Iss 1, Pp 1-15 (2022)
Abstract Background Placenta-derived proteins in the systemic maternal circulation are suggested as potential biomarkers for placental function. However, the identity and longitudinal patterns of such proteins are largely unknown due to the inaccessi
Externí odkaz:
https://doaj.org/article/452d635497eb41518e916b343a3d0fe6
Autor:
Fredrick J. Rosario, Amy Catherine Kelly, Madhulika B. Gupta, Theresa L. Powell, Laura Cox, Thomas Jansson
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Mechanistic Target of Rapamycin Complex 2 (mTORC2) regulates placental amino acid and folate transport. However, the role of mTORC2 in modulating other placental functions is largely unexplored. We used a gene array following the silencing of rictor
Externí odkaz:
https://doaj.org/article/eac172fa88e44145b5c660602dfea016
Autor:
Fredrick J. Rosario, Sammy Pardo, Trond M. Michelsen, Kathryn Erickson, Lorna Moore, Theresa L. Powell, Susan T. Weintraub, Thomas Jansson
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
The placental villus syncytiotrophoblast, the nutrient-transporting and hormone-producing epithelium of the human placenta, is a critical regulator of fetal development and maternal physiology. However, the identities of the proteins synthesized and
Externí odkaz:
https://doaj.org/article/a1e1ff90e67a42889c3486d09aa81298
Autor:
Stephanie S. Chassen, Karin Zemski-Berry, Stefanie Raymond-Whish, Camille Driver, John C. Hobbins, Theresa L. Powell
Publikováno v:
Cells, Vol 11, Iss 19, p 3110 (2022)
Fetal growth restriction (FGR) is associated with short- and long-term morbidity, often with fetal compromise in utero, evidenced by abnormal Doppler velocimetry of fetal vessels. Lipids are vital for growth and development, but metabolism in FGR pre
Externí odkaz:
https://doaj.org/article/1d3e004b4c1941acabf70706810aacf9
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Mechanistic Target of Rapamycin Complex 1 (mTORC1) serves as positive regulator of placental nutrient transport and mitochondrial respiration. The role of mTORC1 signaling in modulating other placental functions is largely unexplored. We used gene ar
Externí odkaz:
https://doaj.org/article/572a0160b8a1476a8d40056113794cfe
Autor:
Laura B James-Allan, Frederick J Rosario, Lana Madi, Kelsey Barner, Soumyalekshmi Nair, Andrew Lai, Flavio Carrion, Theresa L Powell, Carlos Salomon, Thomas Jansson
Publikováno v:
Clinical Science. 136:1535-1549
Small extracellular vesicles (sEVs) play a central role in cell-to-cell communication in normal physiology and in disease, including gestational diabetes mellitus (GDM). The goal of the present study was to test the hypothesis that chronic administra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a29eb8343f47a6036d1c470b08fb18f
https://doi.org/10.1042/cs20220484
https://doi.org/10.1042/cs20220484
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Abstract Maternal folate deficiency is linked to restricted fetal growth, however the underlying mechanisms remain to be established. Here we tested the hypothesis that mTOR functions as a folate sensor in vivo in mice and that maternal folate defici
Externí odkaz:
https://doaj.org/article/281d91b210924359b1352bbc4d3da318