Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Theresa L Gioannini"'
Autor:
Prasad Rallabhandi, Rachel L. Phillips, Marina S. Boukhvalova, Lioubov M. Pletneva, Kari Ann Shirey, Theresa L. Gioannini, Jerrold P. Weiss, Jesse C. Chow, Lynn D. Hawkins, Stefanie N. Vogel, Jorge C. G. Blanco
Publikováno v:
mBio, Vol 3, Iss 4 (2012)
ABSTRACT Respiratory syncytial virus (RSV) is a leading cause of infant mortality worldwide. Toll-like receptor 4 (TLR4), a signaling receptor for structurally diverse microbe-associated molecular patterns, is activated by the RSV fusion (F) protein
Externí odkaz:
https://doaj.org/article/79ea6ff9ae2848cdaa97e9031ac10480
Autor:
Roman Jerala, Theresa L. Gioannini, Sonsoles Martín-Santamaría, Tina Tinkara Peternelj, Jerrold Weiss, Javier Klett, Jožica Vašl, Alja Oblak
Publikováno v:
The Journal of Immunology. 196:2309-2318
Myeloid differentiation factor 2 (MD-2) is an extracellular protein, associated with the ectodomain of TLR4, that plays a critical role in the recognition of bacterial LPS. Despite high overall structural and functional similarity, human (h) and muri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f8d4562beb3c7515527bac33897bd2f7
https://doi.org/10.4049/jimmunol.1502074
https://doi.org/10.4049/jimmunol.1502074
Publikováno v:
Innate Immunity. 19:545-560
A purified complex of metabolically labeled [3H]lipooligosaccharide (LOS) and recombinant human myeloid differentiation factor 2 (MD-2), [3H]LOS·MD-2, has been used to demonstrate pM affinity binding interactions with soluble TLR4 ectodomain (TLR4ec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fc2cc075585f6809f2096ef1c981607
https://doi.org/10.1177/1753425913475688
https://doi.org/10.1177/1753425913475688
Publikováno v:
Innate Immunity. 18:846-855
Recognition of microbial products by members of the Toll-like receptor (TLR) family initiates intracellular signaling cascades that result in NF-κB activation and subsequent production of inflammatory cytokines. We explored the potential roles of mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8f532c5f31b8af36d632dd32b8c8f1e
https://doi.org/10.1177/1753425912443903
https://doi.org/10.1177/1753425912443903
Autor:
Valentina Calabrese, Gaetana Damore, Roberto Cighetti, Francesco Peri, Matteo Piazza, Theresa L. Gioannini, Jerrold Weiss
Publikováno v:
ChemMedChem. 7:213-217
Innate immunity recognition relies on a diverse set of germ line encoded receptors, termed pattern recognition receptors (PRR), which recognize broad classes of molecular structures common to groups of microorganisms. One of the largest and best stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98c1398ec7a042f8cf4fbe4c85bf0a49
https://doi.org/10.1002/cmdc.201100494
https://doi.org/10.1002/cmdc.201100494
Publikováno v:
Innate Immunity. 18:478-491
Response to Gram-negative bacteria (GNB) is partially mediated by the recognition of GNB-derived endotoxin by host cells. Potent host response to endotoxin depends on the sequential interaction of endotoxin with lipopolysaccharide binding protein (LB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08d1f347f5f914c738d542194be4c611
https://doi.org/10.1177/1753425911422723
https://doi.org/10.1177/1753425911422723
Autor:
Francesca Granucci, Davide Prosperi, Miriam Colombo, Jerrold Weiss, Ivan Zanoni, Theresa L. Gioannini, Paolo Tortora, Francesco Peri, Matteo Piazza
Publikováno v:
Angewandte Chemie. 123:648-652
The interaction of highly conserved microbial constituents with the innate immune system contributes greatly to the recognition and reaction against intruding pathogens by mammals. Examples of such microbial constituents include the lipopolysaccharid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ce10ce668809ac17b0248777a5d27da
https://doi.org/10.1002/ange.201004655
https://doi.org/10.1002/ange.201004655
Publikováno v:
The Journal of Immunology. 184:4362-4367
Two missense variants (D299G and T399I) of TLR4 are cosegregated in individuals of European descent and, in a number of test systems, result in reduced responsiveness to endotoxin. How these changes within the ectodomain (ecd) of TLR4 affect TLR4 fun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b99eda8114e877713762c59c9310f62
https://doi.org/10.4049/jimmunol.0903142
https://doi.org/10.4049/jimmunol.0903142
Publikováno v:
The Journal of Immunology. 183:5138-5145
The MD-2/TLR4 complex provides a highly robust mechanism for recognition and response of mammalian innate immunity to Gram-negative bacterial endotoxins. Despite overall close structural and functional similarity, human (h) and murine (m) MD-2 show s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54002e1225fabe4ab5b553b2c93ca674
https://doi.org/10.4049/jimmunol.0901544
https://doi.org/10.4049/jimmunol.0901544
Autor:
Alja Oblak, Roman Jerala, Theresa L. Gioannini, Jožica Vašl, Nuša Resman, Primož Pristovšek, Jerrold Weiss
Publikováno v:
Journal of Biological Chemistry. 284:15052-15060
Gram-negative bacterial endotoxin (i.e. lipopolysaccharide (LPS)) is one of the most potent stimulants of the innate immune system, recognized by the TLR4·MD-2 complex. Direct binding to MD-2 of LPS and LPS analogues that act as TLR4 agonists or ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19542fbaad6d1b0edd45a1c4c05f4bf0
https://doi.org/10.1074/jbc.m901429200
https://doi.org/10.1074/jbc.m901429200