Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Theresa Hickman"'
Autor:
Manijeh Daneshmand, Richard H. Patt, Tae-Ho Hwang, Theresa Hickman, John C. Bell, Minhtran C. Ngo, Hyun Cheol Chung, Leyo Ruo, Steven C. Rose, Kara S DuBois, Anne Moon, Yeon Sook Lee, Caroline J. Breitbach, Chang Won Kim, Mong Cho, Tony R. Reid, Byung Geon Rhee, Lara Longpre, Cliona M. Rooney, Riccardo Lencioni, Ho Yeong Lim, James M. Burke, David H. Kirn, Mark Bloomston, Jeong Heo, Mi Kyeong Kim
Publikováno v:
Nature Medicine. 19:329-336
Oncolytic viruses and active immunotherapeutics have complementary mechanisms of action (MOA) that are both self amplifying in tumors, yet the impact of dose on subject outcome is unclear. JX-594 (Pexa-Vec) is an oncolytic and immunotherapeutic vacci
Autor:
Byung-Geon Rhee, Mi-Kyung Kim, Theresa Hickman, Caroline J. Breitbach, Tae-Ho Hwang, Yu Kyung Lee, Sung Yong Oh, Julia L Rintoul, Theresa Falls, David H. Kirn, Hyun Young Woo, Anne Moon, Jeong Heo, John C. Bell, Rick Patt, Kelley Parato, Chang Won Kim
Publikováno v:
Molecular Therapy. 19:1170-1179
JX-594 is a targeted and granulocyte-macrophage colony stimulating factor (GM-CSF) expressing oncolytic poxvirus designed to selectively replicate in and destroy cancer cells through viral oncolysis and tumor-specific immunity. In a phase 1 trial, JX
Autor:
Theresa Hickman, M. Homerin, David H. Kirn, N. Stojkowitz, M. Lusky, James M. Burke, S.C. Rose, C.J. Breitbach, C.W. Kim, Riccardo Lencioni
Publikováno v:
European Journal of Cancer. 51:S405-S406
Autor:
Yee Chao, Riccardo Lencioni, François Habersetzer, Theresa Hickman, Jean-Marc Limacher, James F. Burke, Ari David Baron, Caroline J. Breitbach, Lara Longpre, David H. Kirn, Michel Homerin, Jeong Heo, Richard H. Patt, Monika Lusky, Derek J. Jonker
Publikováno v:
Journal of Clinical Oncology. 31:TPS4161-TPS4161
TPS4161^ Background: Pexa-Vec is a targeted oncolytic and immunotherapeutic vaccinia virus engineered to express human granulocyte-macrophage colony stimulating factor (GM-CSF). Direct oncolysis plus GM-CSF expression stimulates tumor vascular disrup
Autor:
Theresa Hickman, Tae-Ho Hwang, Ung Bae Jeon, Jeong Heo, Caroline J. Breitbach, David H. Kirn, Chang Won Kim, Jun Woo Lee, Hyun Young Woo, Ki Tae Yoon, Lara Longpre, Richard H. Patt, Mong Cho, James F. Burke
Publikováno v:
Journal of Clinical Oncology. 31:4122-4122
4122^ Background: Pexa-Vec is a vaccinia virus engineered to express granulocyte-macrophage colony stimulating factor (GM-CSF), thereby stimulating direct oncolysis, tumor vascular disruption and anti-tumor immunity (Nat Rev Cancer 2009). Pexa-Vec wa
Autor:
Riccardo Lencioni, Michel Homerin, David H. Kirn, Caroline J. Breitbach, Richard H. Patt, Theresa Hickman, Jean-Marc Limacher, James M. Burke, Lara Longpre, Monika Lusky
Publikováno v:
Journal of Clinical Oncology. 30:TPS4152-TPS4152
TPS4152 Background: JX-594 is a first-in-class targeted oncolytic poxvirus designed to selectively replicate in and destroy cancer cells with epidermal growth factor receptor (EGFR)/ ras pathway activation. Direct oncolysis plus GM-CSF expression sti
Autor:
Richard H. Patt, Ung Bae Jeon, David H. Kirn, Theresa Hickman, Hyun Young Woo, Caroline J. Breitbach, Jeong Heo, Kara S DuBois, Ki Tae Yoon, Lara Longpre, Mong Cho, James F. Burke, Chang Won Kim, Tae-Ho Hwang, Jun Woo Lee
Publikováno v:
Journal of Clinical Oncology. 30:e14566-e14566
e14566 Background: JX-594 is a targeted oncolytic vaccinia virus designed to selectively replicate in and destroy cancer cells with epidermal growth factor receptor (EGFR)/ ras pathway activation. Direct oncolysis plus GM-CSF expression is accompanie
Autor:
David H. Kirn, Theresa Hickman, Caroline J. Breitbach, Naomi De Silva, Manijeh Daneshmand, Kelley Parato, Rozanne Arulanandam, John C. Bell, Richard H. Patt
Publikováno v:
Cancer Research. 71:LB-283
JX-594 is a first-in-class targeted oncolytic poxvirus designed to selectively replicate in and destroy cancer cells with cell cycle abnormalities and epidermal growth factor receptor (EGFR)/ras pathway activation. Direct oncolysis plus granulocyte m
Autor:
John C. Bell, Theresa Hickman, Manijeh Daneshmand, Caroline J. Breitbach, Kelley Parato, Richard H. Patt, David H. Kirn, N. De Silva
Publikováno v:
European Journal of Cancer Supplements. 8:128
Autor:
John C. Bell, Caroline J. Breitbach, Mark Bloomston, Ho Yeong Lim, T.-H. Hwang, Leyo Ruo, Richard H. Patt, C.W. Kim, Theresa Hickman, Jeong Heo, Hyun Cheol Chung, David H. Kirn, Tony R. Reid, B.-G. Rhee
Publikováno v:
Journal of Hepatology. 52:S55