Cell-Type-Specific High Throughput Toxicity Testing in Human Midbrain Organoids

Autor: Henrik Renner, Katharina J. Becker, Theresa E. Kagermeier, Martha Grabos, Farsam Eliat, Patrick Günther, Hans R. Schöler, Jan M. Bruder

Publikováno v: Frontiers in Molecular Neuroscience, Vol 14 (2021)

Toxicity testing is a crucial step in the development and approval of chemical compounds for human contact and consumption. However, existing model systems often fall short in their prediction of human toxicity in vivo because they may not sufficient

Externí odkaz: https://doaj.org/article/3fafc522595e473c9de7213b4e759c51

Cell-Type-Specific High Throughput Toxicity Testing in Human Midbrain Organoids

Autor: Hans R. Schöler, Henrik Renner, Jan M. Bruder, Theresa E Kagermeier, Katharina J Becker, Patrick Günther, Martha Grabos, Farsam Eliat

Publikováno v: Frontiers in Molecular Neuroscience
Frontiers in Molecular Neuroscience, Vol 14 (2021)

Toxicity testing is a crucial step in the development and approval of chemical compounds for human contact and consumption. However, existing model systems often fall short in their prediction of human toxicity in vivo because they may not sufficient

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3180a922ec425bd8d6ee4e341c3052b
https://doi.org/10.3389/fnmol.2021.715054

A fully automated high-throughput workflow for 3D-based chemical screening in human midbrain organoids

Autor: Sebastian A. Leidel, Hans R. Schöler, Yaroslav Tsytsyura, Stefan Peischard, Theresa E Kagermeier, Dagmar Zeuschner, Jie Wu, Jan M. Bruder, Guiscard Seebohm, Martha Grabos, Paul Disse, Katharina J Becker, Mandy Otto, Jürgen Klingauf, Henrik Renner

Publikováno v: eLife
eLife, Vol 9 (2020)
Renner, Henrik; Grabos, Martha; Becker, Katharina J; Kagermeier, Theresa E; Wu, Jie; Otto, Mandy; Peischard, Stefan; Zeuschner, Dagmar; TsyTsyura, Yaroslav; Disse, Paul; Klingauf, Jürgen; Leidel, Sebastian A; Seebohm, Guiscard; Schöler, Hans R; Bruder, Jan M (2020). A fully automated high-throughput workflow for 3D-based chemical screening in human midbrain organoids. eLife, 9 eLife Sciences Publications 10.7554/eLife.52904

Three-dimensional (3D) culture systems have fueled hopes to bring about the next generation of more physiologically relevant high-throughput screens (HTS). However, current protocols yield either complex but highly heterogeneous aggregates (‘organo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2af6cafe25b2e8749fddbcb7a904d019