Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Theresa E Hefferan"'
Autor:
Jae Won Choi, Shari L Sutor, Lonn Lindquist, Glenda L Evans, Benjamin J Madden, H Robert Bergen, Theresa E Hefferan, Michael J Yaszemski, Richard J Bram
Publikováno v:
PLoS Genetics, Vol 5, Iss 12, p e1000750 (2009)
Osteogenesis Imperfecta (OI) is a human syndrome characterized by exquisitely fragile bones due to osteoporosis. The majority of autosomal dominant OI cases result from point or splice site mutations in the type I collagen genes, which are thought to
Externí odkaz:
https://doaj.org/article/6198cc03b1f54266bae27fc9975b998a
Publikováno v:
Bone Reports, Vol 14, Iss, Pp 101005-(2021)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96c1811cf0004f13a025e807d4ef601e
https://doi.org/10.1016/j.bonr.2021.101005
https://doi.org/10.1016/j.bonr.2021.101005
Autor:
Frank Rauch, Joan C. Marini, Cathleen L. Raggio, Paul Roschger, Aileen M. Barnes, Erin Carter, Nadja Fratzl-Zelman, Theresa E. Hefferan, Klaus Klaushofer, David R. Eyre, Peter A. Smith, Giorgio Perino, Weizhong Chang, Francis H. Glorieux, MaryAnn Weis
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 101:3516-3525
Context: Type VIII osteogenesis imperfecta (OI; OMIM 601915) is a recessive form of lethal or severe OI caused by null mutations in P3H1, which encodes prolyl 3-hydroxylase 1. Objectives: Clinical and bone material description of non-lethal type VIII
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed94a538a6c73eb47430c5e5253e8c48
https://doi.org/10.1210/jc.2016-1334
https://doi.org/10.1210/jc.2016-1334
Autor:
Michael J. Yaszemski, George F. Muschler, Viviane Luangphakdy, Linda Stockdale, Thomas W. Bauer, M. Brett Runge, Esteban Walker, Mahrokh Dadsetan, Linda G. Griffith, Kentaro Shinohara, Sunil Saini, Hui Pan, Theresa E. Hefferan, Amit Vasanji
Publikováno v:
Tissue Engineering Part A. 19:634-648
Treatment of large segmental bone defects remains an unsolved clinical challenge, despite a wide array of existing bone graft materials. This project was designed to rapidly assess and compare promising biodegradable osteoconductive scaffolds for use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0ee3a5d0bb16e96b92304c9ac50baae
https://doi.org/10.1089/ten.tea.2012.0289
https://doi.org/10.1089/ten.tea.2012.0289
Autor:
Sergey Leikin, Joan C. Marini, Marina Brusel, Nadja Fratzl-Zelman, Theresa E. Hefferan, William H. McAlister, Michael J. Yaszemski, Carl-Johan Rubin, Aileen M. Barnes, Klaus Klaushofer, Katarina Lindahl, Andreas Kindmark, Paul Roschger, Östen Ljunggren, Elena Makareeva, Adele L. Boskey, Steven Mumm, Michael P. Whyte, Efrat Kessler
Publikováno v:
Human Mutation. 32:598-609
Osteogenesis imperfecta (OI) is most often caused by mutations in the type I procollagen genes (COL1A1/COL1A2). We identified two children with substitutions in the type I procollagen C-propeptide cleavage site, which disrupt a unique processing step
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef0f8fe65973b60f19555f09fa42e98d
https://doi.org/10.1002/humu.21475
https://doi.org/10.1002/humu.21475
Autor:
Pedro Domínguez, Pamela Gehron Robey, John D. Termine, Marian F. Young, Kyomi Ibaraki, Theresa E. Hefferan
Publikováno v:
Journal of Bone and Mineral Research. 6:1127-1136
The cis-acting regulatory elements of the osteonectin gene have been studied using a chloramphenicol acetyltransferase (CAT) promoter assay in osteonectin-expressing and nonexpressing cultured cells. When various stretches of the promoter were transi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b29947a6d463e652900e06052d91c271
https://doi.org/10.1002/jbmr.5650061015
https://doi.org/10.1002/jbmr.5650061015
Autor:
Diederik H.R. Kempen, Avudaiappan Maran, Andras Heijink, Wouter J.A. Dhert, Michael J. Yaszemski, Laura B. Creemers, Theresa E. Hefferan, Lichun Lu
Publikováno v:
Biomaterials. 30:2816-2825
Bone regeneration is a coordinated cascade of events regulated by several cytokines and growth factors. Angiogenic growth factors are predominantly expressed during the early phases for re-establishment of the vascularity, whereas osteogenic growth f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::152f5384601008536dc4c5313b6104dd
https://doi.org/10.1016/j.biomaterials.2009.01.031
https://doi.org/10.1016/j.biomaterials.2009.01.031
Autor:
Jason Britson, Andras Heijink, Avudaiappan Maran, Lichun Lu, Laura B. Creemers, Theresa E. Hefferan, Diederik H.R. Kempen, Michael J. Yaszemski, Kelly L. Classic, Wouter J.A. Dhert
Publikováno v:
Journal of Controlled Release. 134:169-176
Non-invasive imaging can provide essential information for the optimization of new drug delivery-based bone regeneration strategies to repair damaged or impaired bone tissue. This study investigates the applicability of nuclear medicine and radiologi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb4375d147aa09aa4aa740e7777ea1db
https://doi.org/10.1016/j.jconrel.2008.11.023
https://doi.org/10.1016/j.jconrel.2008.11.023
Autor:
Jan P. Szatkowski, Michael J. Yaszemski, Slobodan Macura, Prasanna K. Mishra, Theresa E. Hefferan, Lichun Lu, Mahrokh Dadsetan
Publikováno v:
Biomaterials. 29:2193-2202
This study describes investigation of porous photocrosslinked oligo[(polyethylene glycol) fumarate] (OPF) hydrogels as potential matrix for osteoblastic differentiation of marrow stromal cells (MSCs). The porosity and interconnectivity of porous hydr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be07405c187143758a42c69fe722786c
https://doi.org/10.1016/j.biomaterials.2008.01.006
https://doi.org/10.1016/j.biomaterials.2008.01.006
Autor:
Urszula T. Iwaniec, David J. Rickard, Thomas C. Spelsberg, Katrina M. Waters, Jamie C. Hunter, John P. Lydon, Theresa E. Hefferan, Sundeep Khosla, Glenda L. Evans, Russell T. Turner, Bert W. O'Malley
Publikováno v:
Endocrinology. 149:2383-2390
The role of progesterone receptor (PR) signaling in skeletal metabolism is controversial. To address whether signaling through the PR is necessary for normal bone growth and turnover, we performed histomorphometric and microcomputed tomography analys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30492e94d0ae057fd21148f33814ed1a
https://doi.org/10.1210/en.2007-1247
https://doi.org/10.1210/en.2007-1247