Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Theresa A. Kadlecek"'
Autor:
Veronika Horkova, Ales Drobek, Darina Paprckova, Veronika Niederlova, Avishek Prasai, Valeria Uleri, Daniela Glatzova, Markus Kraller, Michaela Cesnekova, Sarka Janusova, Eva Salyova, Oksana Tsyklauri, Theresa A. Kadlecek, Katerina Krizova, René Platzer, Kilian Schober, Dirk H. Busch, Arthur Weiss, Johannes B. Huppa, Ondrej Stepanek
Publikováno v:
Nature Immunology. 24:174-185
The kinase LCK and CD4/CD8 co-receptors are crucial components of the T cell antigen receptor (TCR) signaling machinery, leading to key T cell fate decisions. Despite decades of research, the roles of CD4–LCK and CD8–LCK interactions in TCR trigg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::558e5771858f2dd70484f422099c8b4e
https://doi.org/10.1038/s41590-022-01366-0
https://doi.org/10.1038/s41590-022-01366-0
Autor:
Neel H Shah, Qi Wang, Qingrong Yan, Deepti Karandur, Theresa A Kadlecek, Ian R Fallahee, William P Russ, Rama Ranganathan, Arthur Weiss, John Kuriyan
Publikováno v:
eLife, Vol 5 (2016)
The sequence of events that initiates T cell signaling is dictated by the specificities and order of activation of the tyrosine kinases that signal downstream of the T cell receptor. Using a platform that combines exhaustive point-mutagenesis of pept
Externí odkaz:
https://doaj.org/article/b39beca68cc0453aa3b66feed4aec35e
Publikováno v:
Sci Signal
The cytoplasmic kinase ZAP70 is critical for T cell antigen receptor (TCR) signaling. The R360P mutation in ZAP70 is responsible for an early onset familial autoimmune syndrome. The structural location and biochemical signaling effects of the R360P m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa794d48ddee97c435483b7f78f50a9b
https://doi.org/10.1126/scisignal.abc4479
https://doi.org/10.1126/scisignal.abc4479
Autor:
Yuan-Li Tsai, Marcel Arias Badia, Theresa A Kadlecek, Neel H Shah, Lawrence Fong, Arthur Weiss
Publikováno v:
The Journal of Immunology. 208:166.14-166.14
T cells are critically important for adaptive immune responses. Therefore, maintaining their proper homeostasis an d controlling the magnitude of their responses is critical. To control T cell responses, T cell activity is negatively regulated by inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7912ceb78d8e9279c1efd45653084574
https://doi.org/10.4049/jimmunol.208.supp.166.14
https://doi.org/10.4049/jimmunol.208.supp.166.14
Autor:
Laura M. Nocka, Theresa A. Kadlecek, Arthur Weiss, John Kuriyan, Aubrianna Decker, Jean K. Chung, Jay T. Groves
Publikováno v:
Biophysical Journal. 118:560a-561a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12bd507ac631b62b4db0e7cf30bb77eb
https://doi.org/10.1016/j.bpj.2019.11.3060
https://doi.org/10.1016/j.bpj.2019.11.3060
Autor:
Qi Wang, Laura M. Nocka, Jay T. Groves, Aubrianna Decker, Jean K. Chung, Arthur Weiss, Theresa A. Kadlecek, John Kuriyan
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 116(22)
The transformation of molecular binding events into cellular decisions is the basis of most biological signal transduction. A fundamental challenge faced by these systems is that reliance on protein–ligand chemical affinities alone generally result
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f08a6e0240f1fa69d6da0301ea607f4a
https://pubmed.ncbi.nlm.nih.gov/31076553
https://pubmed.ncbi.nlm.nih.gov/31076553
Autor:
Rajgopal Srinivasan, Divya Punwani, Erin F. Mathes, Theresa A. Kadlecek, Arthur Weiss, Alice Y. Chan, Shu Man Fu, Jean L. Olson, Uma Sunderam, Morton J. Cowan, Steven E. Brenner, Jennifer M. Puck, John Kuriyan
Publikováno v:
The Journal of experimental medicine, vol 213, iss 2
Chan, AY; Punwani, D; Kadlecek, TA; Cowan, MJ; Olson, JL; Mathes, EF; et al.(2016). A novel human autoimmune syndrome caused by combined hypomorphic and activating mutations in ZAP-70. Journal of Experimental Medicine, 213(2), 155-165. doi: 10.1084/jem.20150888. UCSF: Retrieved from: http://www.escholarship.org/uc/item/6dg18051
The Journal of Experimental Medicine
Chan, AY; Punwani, D; Kadlecek, TA; Cowan, MJ; Olson, JL; Mathes, EF; et al.(2016). A novel human autoimmune syndrome caused by combined hypomorphic and activating mutations in ZAP-70. Journal of Experimental Medicine, 213(2), 155-165. doi: 10.1084/jem.20150888. UCSF: Retrieved from: http://www.escholarship.org/uc/item/6dg18051
The Journal of Experimental Medicine
Chan et al. describe a combination of alleles with hypomorphic and activating mutations in the T cell signaling molecule ZAP-70 in a patient with autoimmunity.
A brother and sister developed a previously undescribed constellation of autoimmune m
A brother and sister developed a previously undescribed constellation of autoimmune m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::088812f4b171200f6fc8278cf15dca4e
https://doi.org/10.1084/jem.20150888
https://doi.org/10.1084/jem.20150888
Autor:
Arthur Weiss, John Kuriyan, Laura M. Nocka, Theresa A. Kadlecek, Jean K. Chung, Qi Wang, Jay T. Groves
The transformation of molecular binding events into cellular decisions is the basis of most biological signal transduction. A fundamental challenge faced by these systems is that protein-ligand chemical affinities alone generally result in poor sensi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bae5469e77e0546ba0a041dfcd8850c
https://doi.org/10.1101/284000
https://doi.org/10.1101/284000
Autor:
Ginell Elliott, Taoping Shi, Junchen Gu, Marco A. Marra, Philippe Gascard, Yan Zhou, Xiaoyun Xing, Daofeng Li, Chibo Hong, Angela Tam, Joseph F. Costello, Ting Wang, Pamela A. F. Madden, Nan Lin, Bo Zhang, Hyung Joo Lee, Michael Stevens, Peggy J. Farnham, Theresa A. Kadlecek, Henriette O'Geen, Baoxue Zhang, Arthur Weiss, Jia Zhou, Thea D. Tlsty, Martin Hirst, Vasavi Sundaram, Richard A. Moore, Raman P. Nagarajan, Keith L. Ligon, Jeffrey B. Cheng, Mahvash Sigaroudinia, Cecile L. Maire, Rebecca F. Lowdon
Publikováno v:
Genome Research. 23:1522-1540
DNA methylation plays key roles in diverse biological processes such as X chromosome inactivation, transposable element repression, genomic imprinting, and tissue-specific gene expression. Sequencing-based DNA methylation profiling provides an unprec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5534423fa2b10bd310455e5d9b7fb3e0
https://doi.org/10.1101/gr.156539.113
https://doi.org/10.1101/gr.156539.113
Autor:
Sebastian Deindl, Arthur Weiss, Tiago Barros, John Kuriyan, Qingrong Yan, Patrick R. Visperas, Theresa A. Kadlecek
Publikováno v:
Molecular and Cellular Biology. 33:2188-2201
Serial activation of the tyrosine kinases Lck and ZAP-70 initiates signaling downstream of the T cell receptor. We previously reported the structure of an autoinhibited ZAP-70 variant in which two regulatory tyrosine residues (315 and 319) in the SH2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eff468e45772c1903dc0e767047c311a
https://doi.org/10.1128/mcb.01637-12
https://doi.org/10.1128/mcb.01637-12