Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Theresa A Kuntzweiler"'
Autor:
Patrick Shum, Thomas Licher, John L. Kane, Carolin Gerbeth-Kreul, Gerhard Hessler, Antje Pommereau, Sven Ruf, Christian Engel, Linli Wei, Joerg Czech, Theresa A Kuntzweiler
Publikováno v:
SLAS Discovery. 26:783-797
Classical high-throughput screening (HTS) technologies for the analysis of ionic currents across biological membranes can be performed using fluorescence-based, radioactive, and mass spectrometry (MS)-based uptake assays. These assays provide rapid r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44e4fb083c4e35d492c537df0250e79a
https://doi.org/10.1177/24725552211011180
https://doi.org/10.1177/24725552211011180
Autor:
Roy J. Vaz, Donglai Yang, Hong Shen, Xin Chen, Stephan Reiling, Raymond Kosley, Theresa A. Kuntzweiler, Joseph D. Batchelor, Ying Zhang, Yi Li, Vinolia Chellaraj, Larry R. McLean
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:3194-3196
This work describes the rational amelioration of Cytochrome P450 4/5 (CYP3A4/5) induction through the Pregnane-X Receptor (PXR) pathway in a series of compounds that modulate the metabotropic glutamate Receptor 2 (mGluR2) via an allosteric mechanism.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::223ef5c9e1949c1ea3dc68860707b446
https://doi.org/10.1016/j.bmcl.2018.08.022
https://doi.org/10.1016/j.bmcl.2018.08.022
Autor:
Mark W. Holladay, Michael Williams, Theresa A. Kuntzweiler, Pamela S. Puttfarcken, Diana L. Donnelly-Roberts, Clark A. Briggs, Anthony W. Bannon, Peter Curzon, Stephen P. Arneric, Michael W. Decker, Arthur L. Nikkel, R. Scott Bitner
Publikováno v:
Journal of Physiology-Paris. 92:221-224
ABT-594, a nicotinic acetylcholine receptor agonist, has antinociceptive effects in rat models of acute thermal, persistent chemical, and neuropathic pain. Direct injection of ABT-594 into the nucleus raphe magnus (NRM) is antinociceptive in a therma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1a1f81a893a5ab180ac725452974ee8
https://doi.org/10.1016/s0928-4257(98)80014-4
https://doi.org/10.1016/s0928-4257(98)80014-4
Publikováno v:
Drug Development Research. 44:14-20
Due to the complex mechanism of cation transport by neuronal nicotinic acetylcholine receptors (nAChR), potential ligands of these receptors must be characterized with respect to functional activity and corresponding subtype selectivity. Conventional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6762fcc29af9e1fc0dd7b43fa2cfce56
https://doi.org/10.1002/(sici)1098-2299(199805)44:1<14::aid-ddr3>3.0.co
https://doi.org/10.1002/(sici)1098-2299(199805)44:1<14::aid-ddr3>3.0.co
Autor:
Stephen P. Arneric, David E. Gunn, Diana L. Donnelly-Roberts, Hao Bai, David J. Anderson, Jeffrey E. Campbell, Yun He, Nan-Horng Lin, James P. Sullivan, Mark W. Holladay, Yihong Li, Theresa A. Kuntzweiler, Keith B. Ryther
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 8:249-254
Analogs of 3-[2-((S)-pyrrolidinyl)methoxy]pyridine (A-84543, 1) with 2-, 4-, 5-, and 6-substituents on the pyridine ring were synthesized. These analogs exhibited Ki values ranging from 0.15 to > 9,000 nM when tested in vitro for neuronal nicotinic a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c67550060a92d9adc388426c5bc5d05
https://doi.org/10.1016/s0960-894x(98)00019-5
https://doi.org/10.1016/s0960-894x(98)00019-5
Autor:
Stephen P. Arneric, Michael Williams, David J.B. Kim, David J. Anderson, Yun He, Michael W. Decker, Diana L. Donnelly-Roberts, Theresa A. Kuntzweiler, Clark A. Briggs, Mark W. Holladay, Anthony W. Bannon, James T. Wasicak, Jeffrey E. Campbell, Keith B. Ryther, Nan-Horng Lin, Marietta Piattoni-Kaplan, Michael J. Buckley
Publikováno v:
Journal of Medicinal Chemistry. 41:407-412
New members of a previously reported series of 3-pyridyl ether compounds are disclosed as novel, potent analgesic agents acting through neuronal nicotinic acetylcholine receptors. Both (R)-2-chloro-5-(2-azetidinylmethoxy)pyridine (ABT-594, 5) and its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81d19c3874a623f054a92340ad391012
https://doi.org/10.1021/jm9706224
https://doi.org/10.1021/jm9706224
Autor:
Stephen P. Arneric, David J. Anderson, Mark W. Holladay, Marietta Piattoni-Kaplan, Keith B. Ryther, Theresa A. Kuntzweiler, Diana L. Donnelly-Roberts, Richard L. Elliott
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:2703-2708
A novel series of 2-(2′-furo[3,2-b]pyridinyl) pyrrolidines has been synthesized and evaluated as novel nicotinic acetylcholine receptor ligands. Changing the pyrrolidine stereochemistry and N-substitution pattern afforded analogs with Ki values ran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::540216a5296bb13a0694c4c2c235df6f
https://doi.org/10.1016/s0960-894x(97)10080-4
https://doi.org/10.1016/s0960-894x(97)10080-4
Publikováno v:
FEBS Letters. 389:179-185
At two intramembrane carboxyl-containing amino acids of the sheep alpha1 isoform of Na,K-ATPase (Asp804 and Asp808), both charge-conserving (Asp to Glu) and charge-deleting (Asp to Asn, Leu and Ala) replacements were made and the altered enzymes stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c540e4e1babb5ab3ae25b588f7dbb20
https://doi.org/10.1016/0014-5793(96)00578-9
https://doi.org/10.1016/0014-5793(96)00578-9
Publikováno v:
ResearcherID
Cardiac glycosides such as ouabain and digoxin specifically inhibit the Na,K-ATPase. Three new residues in the carboxyl half of the Na,K-ATPase, Phe-786, Leu-793 (PFLIF786IIANIPL793PLGT797), and Phe-863 (FTYF863VIM) have been identified as ouabain se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bde2a6682c76989b6190ae57c5b2555
https://doi.org/10.1074/jbc.271.24.14176
https://doi.org/10.1074/jbc.271.24.14176
Autor:
Jeffrey E. Campbell, Yun He, Mark W. Holladay, Yihong Li, Nan-Horng Lin, Stephen P. Arneric, Theresa A. Kuntzweiler, David J. Anderson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:631-633
In an effort to probe the steric influence of C5 substitution of the pyridine ring on CNS binding affinity, analogues of 1 substituted with a bulky moiety—such as phenyl, substituted phenyl, or heteroaryl—were synthesized and tested in vitro for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49c642253190ee14ad2d1875f66a4395
https://doi.org/10.1016/s0960-894x(01)00030-0
https://doi.org/10.1016/s0960-894x(01)00030-0