Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Theresa A Branchek"'
Publikováno v:
Drug Discovery Today: Therapeutic Strategies. 3:467-473
Current anti-depressant treatments do not completely fulfill our expectations in terms of efficacy, onset of action and side effects. For decades, both industrial and academic groups have struggled to identify alternative treatments acting through no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29e3bcffa1283d8cd494f6fdece3b371
https://doi.org/10.1016/j.ddstr.2006.11.010
https://doi.org/10.1016/j.ddstr.2006.11.010
Autor:
John Mehnert Schaus, Lee A. Phebus, John M. Zgombick, David B. Wainscott, Kirk W. Johnson, Kathryn W. Schenck, Brian Michael Mathes, Marlene L. Cohen, David L. Nelson, Jon A. Erickson, Sandra Ann Filla, Theresa A Branchek
Publikováno v:
Journal of Medicinal Chemistry. 46:3060-3071
Compound 1a (LY334370), a selective 5-HT(1F) receptor agonist (SSOFRA), inhibited dural inflammation in the neurogenic plasma protein extravasation model of migraine and demonstrated clinical efficacy for the acute treatment of migraine. Although 1a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5449deb90a0dd708c95822c25ab7a265
https://doi.org/10.1021/jm030020m
https://doi.org/10.1021/jm030020m
Autor:
Beth, Borowsky, Margaret M, Durkin, Kristine, Ogozalek, Mohammad R, Marzabadi, John, DeLeon, Bharat, Lagu, Rainer, Heurich, Harvey, Lichtblau, Zoya, Shaposhnik, Irena, Daniewska, Thomas P, Blackburn, Theresa A, Branchek, Christophe, Gerald, Pierre J, Vaysse, Carlos, Forray
Publikováno v:
Nature Medicine. 8:825-830
Melanin concentrating hormone (MCH) is an orexigenic hypothalamic neuropeptide, which plays an important role in the complex regulation of energy balance and body weight. Here we show that SNAP-7941, a selective, high-affinity MCH1 receptor (MCH1-R)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49ac44e9703f185f24a62c45c73ec22b
https://doi.org/10.1038/nm741
https://doi.org/10.1038/nm741
Autor:
Richard L. Weinshank, S A Kucharewicz, J M Zgombick, Theresa A. Branchek, D.A Urquhart, J. A. Bard
Publikováno v:
Neuropharmacology. 36:513-524
Human 5-HT1B and 5-HT1D receptors have been implicated as molecular targets for the treatment of acute migraine based upon the pharmacological actions and clinical efficacy of sumatriptan, an agonist for human 5-HT1B/1D receptors. The guinea pig has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6481d75833c77ab2501f19583144dbf6
https://doi.org/10.1016/s0028-3908(97)00023-3
https://doi.org/10.1016/s0028-3908(97)00023-3
Autor:
J. A. Bard, Richard L. Weinshank, N. Adham, Theresa A. Branchek, S A Kucharewicz, J M Zgombick, Margaret M. Durkin
Publikováno v:
Neuropharmacology. 36:569-576
The anti-migraine compound, sumatriptan, has been shown to have substantial affinity for the cloned human 5-HT1F receptor suggesting that, in addition to 5-HT1B/5-HT1D receptor subtypes, the 5-HT1F receptor may be a therapeutic target for the treatme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b668c57687a3abca13adadff10f96ad3
https://doi.org/10.1016/s0028-3908(97)00020-8
https://doi.org/10.1016/s0028-3908(97)00020-8
Autor:
Leoluca Criscione, Richard L. Weinshank, Robert I. Taber, Christine Batzl-Hartmann, Eric L. Gustafson, Thomas M. Laz, Andrea O. Schaffhauser, Pierre J.-J. Vaysse, Margaret M. Durkin, David L. Linemeyer, Kelli E. Smith, Steven Whitebread, K. G. Hofbauer, Mary W. Walker, Theresa A. Branchek, Christophe P. G. Gerald
Publikováno v:
Nature. 382:168-171
Neuropeptide Y (NPY) is a powerful stimulant of food intake and is proposed to activate a hypothalamic 'feeding' receptor distinct from previously cloned Y-type receptors. This receptor was first suggested to explain a feeding response to NPY and rel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a093719ce26d6c1c352a6f678ec635d
https://doi.org/10.1038/382168a0
https://doi.org/10.1038/382168a0
Autor:
Theresa A. Branchek
Publikováno v:
Seminars in Neuroscience. 7:375-382
Throughout the nervous system the receptors for the neurotransmitter serotonin form an unusually diverse set. Receptor-mediated responses to serotonin utilize a large collection of biochemical second messenger pathways, such as the stimulation or inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::481f9b3518553a9c2074c06d250bdd98
https://doi.org/10.1016/1044-5765(95)90001-2
https://doi.org/10.1016/1044-5765(95)90001-2
Autor:
P. J.-J. Vaysse, J. A. Salon, N. Adham, Richard L. Weinshank, Theresa A. Branchek, J. A. Tamm
Publikováno v:
Neuropharmacology. 33:387-391
The serotonin 5-HT1B and 5-HT1A receptors bind certain beta-adrenergic antagonists, such as propranolol and pindolol, with high affinity. Other 5-HT1 receptors that display very low affinity for beta-adrenergic antagonists, have either a threonine (T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7bcb7e037ab2656519992848bcc004a
https://doi.org/10.1016/0028-3908(94)90068-x
https://doi.org/10.1016/0028-3908(94)90068-x
Autor:
Richard L. Weinshank, H T Kao, Theresa A. Branchek, D.A Urquhart, L E Schecter, Paul R. Hartig, Nika Adham, Margaret M. Durkin, M A Olsen, J. A. Bard
Publikováno v:
Proceedings of the National Academy of Sciences. 90:408-412
An intronless gene encoding an additional human serotonin (5-HT) 5-HT1-like receptor subtype was isolated from a human genomic library with probes obtained from degenerate PCR primers used to amplify 5-HT-receptor-specific sequences. The highest degr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4b2fbeb2e439cb2594578a14bc308ba
https://doi.org/10.1073/pnas.90.2.408
https://doi.org/10.1073/pnas.90.2.408
Autor:
Xuexiang Zhang, Michael Konkel, Kang Zheng, Zhi-Qing David Xu, Thomas P. Blackburn, Heidi Chen, Christophe P. G. Gerald, Mary W. Walker, Chad J. Swanson, Douglas A. Craig, Toni D. Wolinsky, Tomas Hökfelt, Huailing Zhong, Theresa A. Branchek
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 102(48)
The neuropeptide galanin mediates its effects through the receptor subtypes Gal 1 , Gal 2 , and Gal 3 and has been implicated in anxiety- and depression-related behaviors. Nevertheless, the receptor subtypes relevant to these behaviors are not known
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::600306fdfbfb0a74c0169c8e2a9d970f
https://pubmed.ncbi.nlm.nih.gov/16287967
https://pubmed.ncbi.nlm.nih.gov/16287967