Zobrazeno 1 - 10
of 132
pro vyhledávání: '"Therapy targets"'
Autor:
Yina Wang, Liangyou Rui
Publikováno v:
Onco, Vol 4, Iss 3, Pp 217-231 (2024)
Liver cancer imposes a pervasive global health challenge, ranking among the most prevalent cancers worldwide. Its prevalence and mortality rates are on a concerning upward trajectory and exacerbated by the dearth of efficacious treatment options. The
Externí odkaz:
https://doaj.org/article/c60e0ebbb9a340b3864bbeccea72390e
Publikováno v:
Journal of Inflammation Research, Vol Volume 16, Pp 6087-6105 (2023)
Chujun Chen, Zerui Yang, Zhikun Qiu Key Specialty of Clinical Pharmacy, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, 510080, People’s Republic of ChinaCorrespondence: Zhikun Qiu, Email tougaoqzk@126.comPurpose: G
Externí odkaz:
https://doaj.org/article/3ba3334805a54a6b90a0959a37834f19
Autor:
Ning-ning Yue, Hao-ming Xu, Jing Xu, Min-zheng Zhu, Yuan Zhang, Cheng-Mei Tian, Yu-qiang Nie, Jun Yao, Yu-jie Liang, De-feng Li, Li-sheng Wang
Publikováno v:
Molecular Therapy: Oncolytics, Vol 30, Iss , Pp 193-215 (2023)
Advancements in understanding the pathogenesis mechanisms underlying gastrointestinal diseases, encompassing inflammatory bowel disease, gastrointestinal cancer, and gastroesophageal reflux disease, have led to the identification of numerous novel th
Externí odkaz:
https://doaj.org/article/2221b0bf030945b98deb62ad4a640961
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Globally, the prevalence and fatality rates of liver disorders are on the rise. Among chronic liver conditions, hepatic fibrosis stands out as a central pathological process. Despite this, approved treatments for hepatic fibrosis are currently lackin
Externí odkaz:
https://doaj.org/article/aa85ed10f4dd41b1b2469702513f1df0
Publikováno v:
Ophthalmology and Therapy, Vol 12, Iss 3, Pp 1519-1534 (2023)
Abstract Adiponectin, one of the most ubiquitous adipokines found in the blood, plays a major role in glucolipid metabolism and energy metabolism and regulation. In recent years, a growing body of research indicates that adiponectin also plays a sign
Externí odkaz:
https://doaj.org/article/427ce292041b46449c41f1cea15d5134
Super enhancers: Pathogenic roles and potential therapeutic targets for acute myeloid leukemia (AML)
Publikováno v:
Genes and Diseases, Vol 9, Iss 6, Pp 1466-1477 (2022)
Acute myeloid leukemia (AML) is a malignant hematological tumor with disordered oncogenes/tumor suppressor genes and limited treatments. The potent anti-cancer effects of bromodomain and extra-terminal domain (BET) inhibitors, targeting the key compo
Externí odkaz:
https://doaj.org/article/96fa857a76e5494db22824624576d7cf
Autor:
Michele Correale, Lucia Tricarico, Francesca Croella, Simona Alfieri, Francesco Fioretti, Natale Daniele Brunetti, Riccardo M. Inciardi, Savina Nodari
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
Despite recent advances in chronic heart failure (HF) management, the prognosis of HF patients is poor. This highlights the need for researching new drugs targeting, beyond neurohumoral and hemodynamic modulation approach, such as cardiomyocyte metab
Externí odkaz:
https://doaj.org/article/c7c1c6fd3c184353a56d6ce12107f6aa
Autor:
Vladimir V. Loukachov, Karel A. van Dort, Irma Maurer, R. Bart Takkenberg, Anniki de Niet, Henk W. Reesink, Sophie B. Willemse, Neeltje A. Kootstra
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Background and AimsWith current standard of care a functional cure for Chronic Hepatitis B (CHB) is only achieved in 1-3% of patients and therefore novel therapies are needed. Disease activity during CHB can be determined by a broad range of virologi
Externí odkaz:
https://doaj.org/article/7d1b1f66e52d4143b82e49dffa1fa3d9
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Circular RNAs (circRNAs) are a novel class of noncoding RNAs, which are mainly formed as a loop structure at the exons caused by noncanonical splicing; they are much more stable than linear transcripts; recent reports have suggested that the dysregul
Externí odkaz:
https://doaj.org/article/d0108f7d5cff4a0db938cdf944510380
Autor:
Michele Correale, Lucia Tricarico, Martino Fortunato, Pietro Mazzeo, Savina Nodari, Matteo Di Biase, Natale Daniele Brunetti
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
Despite recent advances in chronic heart failure management (either pharmacological or non-pharmacological), the prognosis of heart failure (HF) patients remains poor. This poor prognosis emphasizes the need for developing novel pathways for testing
Externí odkaz:
https://doaj.org/article/936663f7e9b446099cc1e008198b64a4