De novo gene mutations in normal human memory B cells

Autor: Jeroen E. J. Guikema, Koen Wagner, M. J. Kwakkenbos, Aldo Jongejan, C. J. M. Van Noesel, Richard J. Bende, Thera A. M. Wormhoudt, A. C. M. van Kampen, Linda M. Slot, Aranka V Ballering

Publikováno v: Leukemia, 33(5), 1219-1230. Nature Publishing Group

In the past years, the genomes of thousands of tumors have been elucidated. To date however, our knowledge on somatic gene alterations in normal cells is very limited. In this study, we demonstrate that tetanus-specific human memory B lymphocytes car

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0642b71017d3463a53b8f53732e29cc6
https://doi.org/10.1038/s41375-018-0289-4

Salivary Gland Mucosa-Associated Lymphoid Tissue-Type Lymphoma From Sjögren's Syndrome Patients in the Majority Express Rheumatoid Factors Affinity-Selected for IgG

Autor: Koen Wagner, Frans G. M. Kroese, Thera A. M. Wormhoudt, Jeroen E. J. Guikema, Richard J. Bende, Anna Beentjes, Jerry Janssen, Erlin A. Haacke, Carel J. M. van Noesel

Publikováno v: Arthritis & rheumatology (Hoboken, N.J.), 72(8), 1330-1340. John Wiley and Sons Ltd
Arthritis & Rheumatology, 72(8), 1330-1340. Wiley
Arthritis & Rheumatology (Hoboken, N.j.)

OBJECTIVE: Patients with Sjӧgren's syndrome (SS) have an increased risk of developing malignant B cell lymphomas, particularly mucosa-associated lymphoid tissue (MALT)-type lymphomas. We have previously shown that a predominant proportion of patient

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19bac0565ffe8047adbece197b9415ad
https://pubmed.ncbi.nlm.nih.gov/32182401

OP0179 Molecular documentation of the clonal evolution of a diffuse large b-cell lymphoma out of clonally expanded rheumatoid factor-expressing b cells in a sjÖgren’s syndrome patient

Autor: Jeroen E. J. Guikema, Aldo Jongejan, Thera A. M. Wormhoudt, M. J. Kwakkenbos, Linda M. Slot, A. H. C. van Kampen, Richard J. Bende, C. J. M. Van Noesel

Publikováno v: THURSDAY, 14 JUNE 2018.

Background Sjogren’s syndrome (SS) is the autoimmune disease with the highest risk of lymphoma development. SS patients develop most frequently MALT lymphoma and to a lesser extent diffuse large B-cell lymphoma (DLBCL). Previously, we have shown th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d5e564f76e12759cda0a6c3a68e60a5d
https://doi.org/10.1136/annrheumdis-2018-eular.4401

B-Lymphoblastic Lymphomas Evolving from Follicular Lymphomas Co-Express Surrogate Light Chains and Mutated Gamma Heavy Chains

Autor: Bart J. Biemond, Philippus Kluin, Thera A. M. Wormhoudt, Andre B. Mulder, Monique E.C.M. Oud, Linda M. Slot, Robbert Hoogeboom, Aldo Jongejan, Laura A. Smit, Richard J. Bende, Antoine H. C. van Kampen, Carel J. M. van Noesel, Esther J. M. Schilder-Tol, Jeroen E. J. Guikema

Publikováno v: American journal of pathology, 186(12), 3273-3284. Elsevier Inc.
Slot, L M, Hoogeboom, R, Smit, L A, Wormhoudt, T A M, Biemond, B J, Oud, M E C M, Schilder-Tol, E J M, Mulder, A B, Jongejan, A, van Kampen, A H C, Kluin, P M, Guikema, J E J, Bende, R J & van Noesel, C J M 2016, ' B-Lymphoblastic Lymphomas Evolving from Follicular Lymphomas Co-Express Surrogate Light Chains and Mutated Gamma Heavy Chains ', American Journal of Pathology, vol. 186, no. 12, pp. 3273-3284 . https://doi.org/10.1016/j.ajpath.2016.07.027
The American Journal of Pathology, 186(12), 3273-3284. Elsevier
The American Journal of Pathology, 186(12), 3273-3284. ELSEVIER SCIENCE INC

Follicular lymphoma (FL) is an indolent B-cell non-Hodgkin lymphoma able to transform into germinal center-type diffuse large B-cell lymphoma. We describe four extraordinary cases of FL, which progressed to TdT+CD20- precursor B-lymphoblastic lymphom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f2f7a6d6b8aebb3e4378133a0c37fdb
https://pure.amc.nl/en/publications/blymphoblastic-lymphomas-evolving-from-follicular-lymphomas-coexpress-surrogate-light-chains-and-mutated-gamma-heavy-chains(e5531c88-fcd4-4088-8b88-7dd201297b63).html

A novel chronic lymphocytic leukemia subset expressing mutated IGHV3-7-encoded rheumatoid factor B-cell receptors that are functionally proficient

Autor: Richard J. Bende, Thera A. M. Wormhoudt, M R Schipperus, Deborah K. Dunn-Walters, Anthonie Willem Langerak, C. J. M. Van Noesel, Jeroen E. J. Guikema, Robbert Hoogeboom

Publikováno v: Leukemia, 27(3), 738-740. Nature Publishing Group

A novel chronic lymphocytic leukemia subset expressing mutated IGHV3-7-encoded rheumatoid factor B-cell receptors that are functionally proficient

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d3fcb3b5a7a97add1177e548f558d9d
https://doi.org/10.1038/leu.2012.238