Anti-Proliferative Potential of Secondary Metabolites from the Marine Sponge Theonella sp.: Moving from Correlation toward Causation

Autor: Kuei-Hung Lai, Bo-Rong Peng, Chun-Han Su, Mohamed El-Shazly, Yi-Long Sun, Ming-Cheng Shih, Yu-Ting Huang, Pei-Tzu Yen, Lung-Shuo Wang, Jui-Hsin Su

Publikováno v: Metabolites, Vol 11, Iss 8, p 532 (2021)

Marine sponges have been recognized as a rich source of potential anti-proliferative metabolites. Currently, there are two sponge-derived anti-cancer agents (a macrolide and a nucleoside) isolated from the Porifera phylum, suggesting the great potent

Externí odkaz: https://doaj.org/article/42df0fd6c1b04040bfdcebcdd5bfd016

Bafilomycins N and O, novel cytotoxic bafilomycin analogues produced by Streptomyces sp. GIC10-1 isolated from marine sponge Theonella sp

Autor: Yu Hsin Chen, Ching-Feng Weng, Ping-Jyun Sung, Juan-Cheng Yang, Mei-Chin Lu, Yin Di Su, Yang Chang Wu, Jimmy Kuo

Publikováno v: Tetrahedron. 73:5170-5175

Two novel 16-membered tetraene marcolides, bafilomycins N (1) and O (2), along with two known analogues, JBIR-100 (3) and bafilomycin K (4) were produced from isolate GIC10-1, a Streptomyces sp. strain that was originally cloned from bacterial commun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d5d40ad37f85e1e000f4346486fa049b
https://doi.org/10.1016/j.tet.2017.07.009

Lanesoic Acid: A Cytotoxic Zwitterion from Theonella sp

Autor: Carlos Jiménez, Jaime Rodríguez, María M. Blanco, Guillermo Tarazona, Carmen Cuevas, Rogelio Fernández

Publikováno v: Organic Letters. 18:5832-5835

Lanesoic acid (1) was isolated and characterized from Theonella sp. during PharmaMar’s ongoing program to study cytotoxic substances from marine sources. Its planar structure, elucidated by spectral analysis (NMR, IR, UV, and MS), possesses an unus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b695073f1d4b6dc646b0c730ccaf7d19
https://doi.org/10.1021/acs.orglett.6b02832

The swinholide biosynthesis gene cluster from a terrestrial cyanobacterium, Nostoc sp. strain UHCC 0450

Autor: David P. Fewer, Anu Humisto, Liwei Liu, João Paulo Machado, Hao Wang, Perttu Permi, Agostinho Antunes, Jouni Jokela, Matti Wahlsten, Kaarina Sivonen

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Applied and Environmental Microbiology

Swinholides are 42-carbon ring polyketides with a 2-fold axis of symmetry. They are potent cytotoxins that disrupt the actin cytoskeleton. Swinholides were discovered from the marine sponge Theonella sp. and were long suspected to be produced by symb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff5a9e7d4141651b972da4642bb57996

Stereochemistry of theonezolides A–C

Autor: Kohei Nozawa, Takaaki Kubota, Naonobu Tanaka, Masashi Tsuda, Eri Fukushi, Jun Kawabata, Jun'ichi Kobayashi

Publikováno v: Tetrahedron Letters. 54:783-787

Theonezolides A–C (1–3) are cytotoxic 37-membered macrolides with a long side chain isolated from an Okinawan marine sponge Theonella sp. The relative stereochemistry of 1–3 was investigated by combination of NMR analysis including application

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2493cb172e4361fa46939aa7ed1634d9
https://doi.org/10.1016/j.tetlet.2012.11.120