iPSC-induced neurons with the V337M MAPT mutation are selectively vulnerable to caspase-mediated cleavage of tau and apoptotic cell death.

Autor: Theofilas P; Memory and Aging Center, Department of Neurology, UCSF, San Francisco, CA, USA., Wang C; Gladstone Institute of Neurological Disease, San Francisco, CA, USA., Butler D; Neural Stem Cell Institute, Rensselaer, NY, USA., Morales DO; Memory and Aging Center, Department of Neurology, UCSF, San Francisco, CA, USA., Petersen C; Memory and Aging Center, Department of Neurology, UCSF, San Francisco, CA, USA., Ambrose A; Department of Pharmaceutical Chemistry and Small Molecule Discovery Center, UCSF, San Francisco, CA, USA., Chin B; Shanghai ChemPartner, Shanghai, China., Yang T; Shanghai ChemPartner, Shanghai, China., Khan S; ChemPartner San Francisco, South San Francisco, CA, USA., Ng R; ChemPartner San Francisco, South San Francisco, CA, USA., Kayed R; Department of Neurology, University of Texas Medical Branch, Galveston, TX, USA., Karch CM; Washington University School of Medicine, St Louis, MO, USA., Miller BL; Memory and Aging Center, Department of Neurology, UCSF, San Francisco, CA, USA., Gestwicki JE; Department of Pharmaceutical Chemistry, UCSF, San Francisco, CA, USA., Gan L; Gladstone Institute of Neurological Disease, San Francisco, CA, USA; Helen and Robert Appel Alzheimer's Disease Research Institute, Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA., Temple S; Neural Stem Cell Institute, Rensselaer, NY, USA., Arkin MR; Department of Pharmaceutical Chemistry and Small Molecule Discovery Center, UCSF, San Francisco, CA, USA. Electronic address: Michelle.arkin@ucsf.edu., Grinberg LT; Memory and Aging Center, Department of Neurology, UCSF, San Francisco, CA, USA; Department of Pathology, University of Sao Paulo Medical School, Brazil. Electronic address: lea.grinberg@ucsf.edu.

Publikováno v: Molecular and cellular neurosciences [Mol Cell Neurosci] 2024 Sep; Vol. 130, pp. 103954. Date of Electronic Publication: 2024 Jul 20.

A Comprehensive Resource for Induced Pluripotent Stem Cells from Patients with Primary Tauopathies

Autor: Celeste M. Karch, Aimee W. Kao, Anna Karydas, Khadijah Onanuga, Rita Martinez, Andrea Argouarch, Chao Wang, Cindy Huang, Peter Dongmin Sohn, Kathryn R. Bowles, Salvatore Spina, M. Catarina Silva, Jacob A. Marsh, Simon Hsu, Derian A. Pugh, Nupur Ghoshal, Joanne Norton, Yadong Huang, Suzee E. Lee, William W. Seeley, Panagiotis Theofilas, Lea T. Grinberg, Fermin Moreno, Kathryn McIlroy, Bradley F. Boeve, Nigel J. Cairns, John F. Crary, Stephen J. Haggarty, Justin K. Ichida, Kenneth S. Kosik, Bruce L. Miller, Li Gan, Alison M. Goate, Sally Temple, Carolina Alquezar, Kathryn Bowles, David Butler, Israel Hernandez, Valerie Hennes, Martin Kampmann

Publikováno v: Stem Cell Reports, Vol 13, Iss 5, Pp 939-955 (2019)

Summary: Primary tauopathies are characterized neuropathologically by inclusions containing abnormal forms of the microtubule-associated protein tau (MAPT) and clinically by diverse neuropsychiatric, cognitive, and motor impairments. Autosomal domina

Externí odkaz: https://doaj.org/article/598d132842794126ace928eb080d817b

The mechanistic link between selective vulnerability of the locus coeruleus and neurodegeneration in Alzheimer's disease.

Autor: Matchett BJ; Neuropathology Laboratory, Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA., Grinberg LT; Memory and Aging Center, Department of Neurology, University of California, 675 Nelson Rising Lane, San Francisco, CA, 94158, USA., Theofilas P; Memory and Aging Center, Department of Neurology, University of California, 675 Nelson Rising Lane, San Francisco, CA, 94158, USA. Panos.Theofilas@ucsf.edu., Murray ME; Neuropathology Laboratory, Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA. Murray.Melissa@mayo.edu.

Publikováno v: Acta neuropathologica [Acta Neuropathol] 2021 May; Vol. 141 (5), pp. 631-650. Date of Electronic Publication: 2021 Jan 11.

Caspase‐6‐cleaved tau is relevant in Alzheimer's disease but not in 4‐repeat tauopathies: Diagnostic and therapeutic implications.

Autor: Piergies, Antonia M. H., Theofilas, Panos, Li, Song, Petersen, Cathrine, Ehrenberg, Alexander J., Eser, Rana April, Chin, Brian, Yang, Teddy, Khan, Shireen, Ng, Raymond, Spina, Salvatore, Seeley, William W., Miller, Bruce L., Arkin, Michelle R., Grinberg, Lea T.

Publikováno v: Alzheimer's & Dementia: The Journal of the Alzheimer's Association; Dec2021 Supplement S3, Vol. 17 Issue 3, p1-5, 5p

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