Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Theodosia Vallianatou"'
Autor:
Ibrahim Kaya, Anna Nilsson, Dominika Luptáková, Yachao He, Theodosia Vallianatou, Patrik Bjärterot, Per Svenningsson, Erwan Bezard, Per E. Andrén
Publikováno v:
npj Parkinson's Disease, Vol 9, Iss 1, Pp 1-10 (2023)
Abstract Metabolism of MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) to the neurotoxin MPP+ in the brain causes permanent Parkinson’s disease-like symptoms by destroying dopaminergic neurons in the pars compacta of the substantia nigra in hum
Externí odkaz:
https://doaj.org/article/3c661f82385146aa87fdf62d51986805
Autor:
Heather Hulme, Elva Fridjonsdottir, Theodosia Vallianatou, Reza Shariatgorji, Anna Nilsson, Qin Li, Erwan Bezard, Per E. Andrén
Publikováno v:
npj Parkinson's Disease, Vol 8, Iss 1, Pp 1-11 (2022)
Abstract L-DOPA administration is the primary treatment for Parkinson’s disease (PD) but long-term administration is usually accompanied by hyperkinetic side-effects called L-DOPA-induced dyskinesia (LID). Signaling neuropeptides of the basal gangl
Externí odkaz:
https://doaj.org/article/ca923e27a978411da1b704e62974977d
Publikováno v:
Molecules, Vol 27, Iss 12, p 3668 (2022)
The development of high-throughput approaches for the valid estimation of brain disposition is of great importance in the early drug screening of drug candidates. However, the complexity of brain tissue, which is protected by a unique vasculature for
Externí odkaz:
https://doaj.org/article/65a59db46d5f4dd89a1c58e04873fbe1
Autor:
Heather Hulme, Elva Fridjonsdottir, Halla Gunnarsdottir, Theodosia Vallianatou, Xiaoqun Zhang, Henrik Wadensten, Reza Shariatgorji, Anna Nilsson, Erwan Bezard, Per Svenningsson, Per E. Andrén
Publikováno v:
Neurobiology of Disease, Vol 137, Iss , Pp 104738- (2020)
Neuropeptides are important signalling molecules in the brain and alterations in their expression levels have been linked to neurological disorders such as Parkinson's disease. It is challenging to map neuropeptide changes across and within brain reg
Externí odkaz:
https://doaj.org/article/417cce8aeadc4bedbb39202384ddd14f
Autor:
Theodosia Vallianatou, Nicholas B. Bèchet, Mario S. P. Correia, Iben Lundgaard, Daniel Globisch
Publikováno v:
Metabolites, Vol 12, Iss 1, p 21 (2021)
Sleep is a state in which important restorative and anabolic processes occur. Understanding changes of these metabolic processes during the circadian rhythm in the brain is crucial to elucidate neurophysiological mechanisms important for sleep functi
Externí odkaz:
https://doaj.org/article/17097f0fc6654f56a7d800543ddba3a8
Autor:
Elva Fridjonsdottir, Theodosia Vallianatou, Ioannis Mantas, Reza Shariatgorji, Anna Nilsson, Luke S. Schembri, Luke R. Odell, Per Svenningsson, Per E. Andrén
Publikováno v:
ACS Chemical Biology
Regional brain distribution and metabolism of neurotransmitters and their response to drug treatment are fundamentally important for understanding the central effects of neuroactive substances. We used matrix-assisted laser desorption/ionization mass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c13280781a496273da28200a0e85c1f
http://europepmc.org/articles/PMC8787750
http://europepmc.org/articles/PMC8787750
Autor:
Mário S. P. Correia, Daniel Globisch, Theodosia Vallianatou, Nagesh C Shanbhag, Iben Lundgaard, Nicholas Burdon Bechet, Weifeng Lin
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism
Sleep has evolved as a universal core function to allow for restorative biological processes. Detailed knowledge of metabolic changes necessary for the sleep state in the brain is missing. Herein, we have performed an in-depth metabolic analysis of f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0233bcd6b588a40573632c4dcb156ca
https://doi.org/10.1177/0271678x211033358
https://doi.org/10.1177/0271678x211033358
Autor:
Theodosia Vallianatou, Marcela Pereira, Florian Barré, Henrik Wadensten, Per E. Andrén, Patrik Källback, Nicoletta Schintu, Anna Nilsson, Reza Shariatgorji, Per Svenningsson
Publikováno v:
Analytical Chemistry
Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) is an established tool in drug development, which enables visualization of drugs and drug metabolites at spatial localizations in tissue sections from different organs.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0721ca51e936fd247cba84b46e7ccb63
https://doi.org/10.1021/acs.analchem.0c03203
https://doi.org/10.1021/acs.analchem.0c03203
Autor:
Luay Katan, Patrik Källback, Erwan Bezard, Theodosia Vallianatou, Per Svenningsson, Per E. Andrén, Anna Nilsson, Ioannis Mantas, Jonas Sävmarker, Elva Fridjonsdottir, Xiaoqun Zhang, Luke R. Odell, Mohammadreza Shariatgorji
Publikováno v:
Nature Methods. 16:1021-1028
We present a mass spectrometry imaging (MSI) approach for the comprehensive mapping of neurotransmitter networks in specific brain regions. Our fluoromethylpyridinium-based reactive matrices facilitate the covalent charge-tagging of molecules contain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8f83981b764be2a5eef0c0fb8a1c371
https://doi.org/10.1038/s41592-019-0551-3
https://doi.org/10.1038/s41592-019-0551-3
Autor:
Dominika, Luptáková, Theodosia, Vallianatou, Anna, Nilsson, Reza, Shariatgorji, Margareta, Hammarlund-Udenaes, Irena, Loryan, Per E, Andrén
Publikováno v:
Molecular psychiatry. 26(12)
Comprehensive determination of the extent of drug transport across the region-specific blood-brain barrier (BBB) is a major challenge in preclinical studies. Multiple approaches are needed to determine the regional free (unbound) drug concentration a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::424cad384a1830497579afdd961b952c
https://pubmed.ncbi.nlm.nih.gov/34480089
https://pubmed.ncbi.nlm.nih.gov/34480089