Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Theodosia, Teo"'
Publikováno v:
Pharmacological Research, Vol 180, Iss , Pp 106249- (2022)
Cyclin-dependent kinase 3 (CDK3) is a major player driving retinoblastoma (Rb) phosphorylation during the G0/G1 transition and in the early G1 phase of the cell cycle, preceding the effects of CDK4/cyclin D, CDK6/cyclin D, and CDK2/cyclin E. CDK3 can
Externí odkaz:
https://doaj.org/article/7f75099e3b6f4eb2b74e828f27063251
Autor:
Biruk Sintayehu Fanta, Jimma Lenjisa, Theodosia Teo, Lianmeng Kou, Laychiluh Mekonnen, Yuchao Yang, Sunita K. C. Basnet, Ramin Hassankhani, Matthew J. Sykes, Mingfeng Yu, Shudong Wang
Publikováno v:
Molecules, Vol 28, Iss 7, p 2951 (2023)
Cyclin-dependent kinase 2 (CDK2) has been garnering considerable interest as a target to develop new cancer treatments and to ameliorate resistance to CDK4/6 inhibitors. However, a selective CDK2 inhibitor has yet to be clinically approved. With the
Externí odkaz:
https://doaj.org/article/e7f7255ec5e440348ed681432266d49d
Autor:
Muhammed H. Rahaman, Frankie Lam, Longjin Zhong, Theodosia Teo, Julian Adams, Mingfeng Yu, Robert W. Milne, Chris Pepper, Noor A. Lokman, Carmela Ricciardelli, Martin K. Oehler, Shudong Wang
Publikováno v:
Molecular Oncology, Vol 13, Iss 10, Pp 2178-2193 (2019)
Colorectal cancer (CRC) remains one of the most lethal human malignancies, and pursuit of new therapeutic targets for treatment has been a major research focus. Cyclin‐dependent kinase 9 (CDK9), which plays a crucial role in transcription, has emer
Externí odkaz:
https://doaj.org/article/cbaa876250d345bd9ed140b6e56eb1f2
Autor:
Saiful Islam, Theodosia Teo, Malika Kumarasiri, Martin Slater, Jennifer H. Martin, Shudong Wang, Richard Head
Publikováno v:
Pharmaceuticals, Vol 15, Iss 10, p 1186 (2022)
The global burden of cancer necessitates rapid and ongoing development of effective cancer therapies. One promising approach in this context is the repurposing of existing non-cancer drugs for cancer indications. A key to this approach is selecting t
Externí odkaz:
https://doaj.org/article/702087c9ed0b4172b10facf3c3e95c8c
Autor:
Renjie Chen, Ramin Hassankhani, Yi Long, Sunita K. C. Basnet, Theodosia Teo, Yuchao Yang, Laychiluh Mekonnen, Mingfeng Yu, Shudong Wang
Publikováno v:
ChemMedChem.
Cyclin-dependent kinases (CDKs) 7 and 9 are deregulated in various types of human cancer and are thus viewed as therapeutic targets. Accordingly, small-molecule inhibitors of both CDKs are highly sought-after. Capitalising on our previous discovery o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83191a927e012c62f7945736ad5349a5
https://pubmed.ncbi.nlm.nih.gov/36400715
https://pubmed.ncbi.nlm.nih.gov/36400715
Autor:
Saiful, Islam, Theodosia, Teo, Malika, Kumarasiri, Martin, Slater, Jennifer H, Martin, Shudong, Wang, Richard, Head
Publikováno v:
Pharmaceuticals (Basel, Switzerland). 15(10)
The global burden of cancer necessitates rapid and ongoing development of effective cancer therapies. One promising approach in this context is the repurposing of existing non-cancer drugs for cancer indications. A key to this approach is selecting t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d463a28f4dd709e096adda5d61b59523
https://pubmed.ncbi.nlm.nih.gov/36297298
https://pubmed.ncbi.nlm.nih.gov/36297298
Autor:
Biruk Sintayehu Fanta, Laychiluh Mekonnen, Sunita K.C. Basnet, Theodosia Teo, Jimma Lenjisa, Nishat Z. Khair, Lianmeng Kou, Solomon Tadesse, Matthew J. Sykes, Mingfeng Yu, Shudong Wang
Publikováno v:
Bioorganic & Medicinal Chemistry. 80:117158
Refereed/Peer-reviewed Deregulation of cyclin-dependent kinase 2 (CDK2) and its activating partners, cyclins A and E, is associated with the pathogenesis of a myriad of human cancers and with resistance to anticancer drugs including CDK4/6 inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b8f63a551dceced78f485f06da01662
https://doi.org/10.1016/j.bmc.2023.117158
https://doi.org/10.1016/j.bmc.2023.117158
Autor:
Renjie Chen, Ramin Hassankhani, Yi Long, Sunita K. C. Basnet, Theodosia Teo, Yuchao Yang, Laychiluh Mekonnen, Mingfeng Yu, Shudong Wang
Publikováno v:
SSRN Electronic Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bff383b48c8ea188b59eff5326d6c2f3
https://doi.org/10.2139/ssrn.4210989
https://doi.org/10.2139/ssrn.4210989
Autor:
Theodosia Teo, Mingfeng Yu, Shudong Wang, Yuchao Yang, Benjamin Noll, Man-jun Li, Yi Long, Stephen Philip
Publikováno v:
European journal of medicinal chemistry. 218
CDK8 is deregulated in multiple types of human cancer and is viewed as a therapeutic target for the treatment of the disease. Accordingly, the search for small-molecule inhibitors of CDK8 is being intensified. Capitalising on our initial discovery of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ef0bc6afe6fdcf34685615d9e589026
https://pubmed.ncbi.nlm.nih.gov/33823391
https://pubmed.ncbi.nlm.nih.gov/33823391
Publikováno v:
Drug discovery today. 25(12)
Cyclin-dependent kinase (CDK) 12 engages in diversified biological functions, from transcription, post transcriptional modification, cell cycle, and translation to cellular proliferation. Moreover, it regulates the expression of cancer-related genes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c8e956defd045c1ee2153ba11cf4ec4
https://pubmed.ncbi.nlm.nih.gov/33038524
https://pubmed.ncbi.nlm.nih.gov/33038524