Oral pimonidazole unveils clinicopathologic and epigenetic features of hypoxic tumour aggressiveness in localized prostate cancer

Autor: Xinpei Ci, Sujun Chen, Rui Zhu, Mojgan Zarif, Rahi Jain, Wangyuan Guo, Matthew Ramotar, Linsey Gong, Wenjie Xu, Olivia Singh, Sheila Mansouri, Gelareh Zadeh, Gong-Hong Wei, Wei Xu, Robert Bristow, Alejandro Berlin, Marianne Koritzinsky, Theodorus van der Kwast, Housheng Hansen He

Publikováno v: BMC Cancer, Vol 24, Iss 1, Pp 1-12 (2024)

Abstract Background Tumor hypoxia is associated with prostate cancer (PCa) treatment resistance and poor prognosis. Pimonidazole (PIMO) is an investigational hypoxia probe used in clinical trials. A better understanding of the clinical significance a

Externí odkaz: https://doaj.org/article/0536003d350a4933803620ed43e2f7a7

The telomere length landscape of prostate cancer

Autor: Julie Livingstone, Yu-Jia Shiah, Takafumi N. Yamaguchi, Lawrence E. Heisler, Vincent Huang, Robert Lesurf, Tsumugi Gebo, Benjamin Carlin, Stefan Eng, Erik Drysdale, Jeffrey Green, Theodorus van der Kwast, Robert G. Bristow, Michael Fraser, Paul C. Boutros

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)

Despite the known role of telomere length in cancer, its association with genomic features remains unclear. Here, the authors integrate telomere length, genomics, transcriptomics and proteomics in localized prostate cancer and reveal links between te

Externí odkaz: https://doaj.org/article/3a1b96dd7f314201be56b49c89bc022a

Noncoding mutations target cis-regulatory elements of the FOXA1 plexus in prostate cancer

Autor: Stanley Zhou, James R. Hawley, Fraser Soares, Giacomo Grillo, Mona Teng, Seyed Ali Madani Tonekaboni, Junjie Tony Hua, Ken J. Kron, Parisa Mazrooei, Musaddeque Ahmed, Christopher Arlidge, Hwa Young Yun, Julie Livingstone, Vincent Huang, Takafumi N. Yamaguchi, Shadrielle M. G. Espiritu, Yanyun Zhu, Tesa M. Severson, Alex Murison, Sarina Cameron, Wilbert Zwart, Theodorus van der Kwast, Trevor J. Pugh, Michael Fraser, Paul C. Boutros, Robert G. Bristow, Housheng Hansen He, Mathieu Lupien

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)

FOXA1 pioneer transcription factor is recurrently mutated in primary and metastatic prostate tumors. Here, authors identify a set of six cis-regulatory elements in the FOXA1 regulatory plexus harboring somatic SNVs in primary prostate tumors and char

Externí odkaz: https://doaj.org/article/ced842dd69954226b920c3219e59c1a5

Best Current Practice and Research Priorities in Active Surveillance for Prostate Cancer-A Report of a Movember International Consensus Meeting

Autor: Caroline M. Moore, Lauren E. King, John Withington, Mahul B. Amin, Mark Andrews, Erik Briers, Ronald C. Chen, Francis I. Chinegwundoh, Matthew R. Cooperberg, Jane Crowe, Antonio Finelli, Margaret I. Fitch, Mark Frydenberg, Francesco Giganti, Masoom A. Haider, John Freeman, Joseph Gallo, Stephen Gibbs, Anthony Henry, Nicholas James, Netty Kinsella, Thomas B.L. Lam, Mark Lichty, Stacy Loeb, Brandon A. Mahal, Ken Mastris, Anita V. Mitra, Samuel W.D. Merriel, Theodorus van der Kwast, Mieke Van Hemelrijck, Nynikka R. Palmer, Catherine C. Paterson, Monique J. Roobol, Phillip Segal, James A. Schraidt, Camille E. Short, M. Minhaj Siddiqui, Clare M.C. Tempany, Arnaud Villers, Howard Wolinsky, Steven MacLennan

Publikováno v: Moore, C M, King, L, Withington, J, Amin, M, Andrews, M, Briers, E, Chen, R, Chinegwundoh, F, Matthew, C, Crowe, J, Finelli, A, Fitch, M, Frydenberg, M, Giganti, F, Haider, M, Freeman, J, Gallo, J, Gibbs, S, Henry, A, James, N, Kinsella, N, Lam, T, Lichty, M, Loeb, S, Mahal, B, Mastris, K, Mitra, A, Merriel, S, van der Kwast, T, van Hemelrijck, M, Palmer, N, Paterson, C, Roobol, M, Segal, P, Schraidt, J, Short, C, Siddiqu, M M, Tempany, C, Villiers, A, Wolinsky, H & MacLennan, S 2023, ' Best Current Practice and Research Priorities in Active Surveillance for Prostate Cancer—A Report of a Movember International Consensus Meeting ', European Urology Oncology . https://doi.org/10.1016/j.euo.2023.01.003
European urology oncology, 6(2), 160-182. Elsevier

BACKGROUND: Active surveillance (AS) is recommended for low-risk and some intermediate-risk prostate cancer. Uptake and practice of AS vary significantly across different settings, as does the experience of surveillance-from which tests are offered,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6973ff56fbc22ce04dd894528db4af7
https://pure.eur.nl/en/publications/409382cf-97bc-4635-a6f7-61db60dde2ed

Images in pathology: The *wild* prostate

Autor: Cornelia Thoeni, Myles Margolis, Ants Toi, Theodorus Van der Kwast

Publikováno v: Human Pathology: Case Reports, Vol 21, Iss , Pp 200412- (2020)

Externí odkaz: https://doaj.org/article/fd5ef152a7464da3a5d0c7a8be750955