Výsledky vyhledávání - "Theodoros Kosteas"

DNA Damage Triggers a Chronic Autoinflammatory Response, Leading to Fat Depletion in NER Progeria

Autor: Tania A. Rozgaja, Georgia Chatzinikolaou, George A. Garinis, Sandra Siakouli, Irene Kamileri, Andria Rasile Robinson, Laura J. Niedernhofer, Eleni Vergadi, Theodoros Kosteas, Iannis Tsamardinos, Ismene Karakasilioti, Christos Tsatsanis

Publikováno v: Cell Metabolism. 18(3):403-415

SummaryLipodystrophies represent a group of heterogeneous disorders characterized by loss of fat tissue. However, the underlying mechanisms remain poorly understood. Using mice carrying an ERCC1-XPF DNA repair defect systematically or in adipocytes,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b6baa09efe9450d4a15d9ce47ba54cc

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Defective transcription initiation causes postnatal growth failure in a mouse model of nucleotide excision repair (NER) progeria

Autor: Irene Kamileri, Ismene Karakasilioti, George A. Garinis, Antonis Tatarakis, Theodoros Kosteas, Iannis Talianidis, Aria Sideri

Publikováno v: Proceedings of the National Academy of Sciences. 109:2995-3000

Nucleotide excision repair (NER) defects are associated with cancer, developmental disorders and neurodegeneration. However, with the exception of cancer, the links between defects in NER and developmental abnormalities are not well understood. Here,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::772e74db7d6ee0f88f1057f6adaad080
https://doi.org/10.1073/pnas.1114941109

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Modulation of the Murine CD8 Gene Complex Following the Targeted Integration of Human CD2-Locus Control Region Sequences

Autor: Ursula Menzel, Kathleen Roderick, Dimitris Kioussis, Nigel Killeen, Mauro Tolaini, Theodoros Kosteas

Publikováno v: The Journal of Immunology. 187:3712-3720

The human CD2 (hCD2) locus control region (LCR) inserted in the mouse CD8 gene complex activates expression of the CD8 genes in T cell subsets in which the CD8 locus is normally silenced (e.g., CD4+ single-positive T cells). In this article, we show

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06dfc19c22ee3093a66727f9b8527fe4
https://doi.org/10.4049/jimmunol.1100709

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Two patients with nonimmune chronic idiopathic neutropenia of adults developing acute myeloid leukemia with aberrant phenotype and complex karyotype but no mutations in granulocyte colony-stimulating factor receptor

Autor: Helen A. Papadaki, M. Psyllaki, George D. Eliopoulos, Claudia Gemetzi, Theodoros Kosteas, Michael G. Alexandrakis

Publikováno v: Annals of Hematology. 81:50-54

It has been suggested that some cases of nonimmune chronic idiopathic neutropenia of adults (NI-CINA) may be considered preleukemic disorders. This paper describes two patients with NI-CINA who developed acute myeloid leukemia (AML) 34 and 64 months,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f77a71915647c0e2108f1287936b1632
https://doi.org/10.1007/s00277-001-0401-z

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Molecular cloning of the breakpoints of the hereditary persistence of fetal hemoglobin type-6 (HPFH-6) deletion and sequence analysis of the novel juxtaposed region from the 3′ end of the β-globin gene cluster

Autor: Antonella Palena, Nicholas P. Anagnou, Theodoros Kosteas

Publikováno v: Human Genetics. 100:441-445

Naturally occurring deletion mutations within the human beta-globin cluster lead to specific, phenotypically discrete syndromes (i.e., delta beta-thalassemias and hereditary persistence of fetal hemoglobin, HPFH), characterized by increased productio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05e7a797f535a42acb315683e98705a3
https://doi.org/10.1007/s004390050530

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Persistent Fetal γ-Globin Expression in Adult Transgenic Mice following Deletion of Two Silencer Elements Located 3′ to the Human Aγ-Globin Gene

Autor: Theodoros Kosteas, Maria Gazouli, Eleni Katsantoni, Nicholas P. Anagnou

Natural deletions of the human gamma-globin gene cluster lead to specific syndromes characterized by increased production of fetal hemoglobin in adult life and provide a useful model to delineate novel cis-acting elements involved in the developmenta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09a9a26a54fc92cd2b78973e5eb9d174
https://europepmc.org/articles/PMC2727461/

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Acute myeloid/NK precursor cell leukemia with trisomy 4 and a novel point mutation in the extracellular domain of the G-CSF receptor in a patient with chronic idiopathic neutropenia

Autor: Helen A. Papadaki, Theodoros Kosteas, Claudia Gemetzi, Athina Damianaki, Nicholas P. Anagnou, George D. Eliopoulos

Publikováno v: Annals of hematology. 83(6)

Chronic idiopathic neutropenia (CIN) has been well recognized as a granulocytic disorder not associated with increased risk to malignant transformation. Four cases, however, of acute myeloid leukemia have been recently reported in patients with CIN.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e694d541e37d52a87470562e9e382a8
https://pubmed.ncbi.nlm.nih.gov/15014900

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