Delivering Dialysis During the COVID-19 Outbreak: Strategies and Outcomes

Autor: Tayeba Roper, Nicola Kumar, Timothy Lewis-Morris, Vicki Moxham, Theodoros Kassimatis, David Game, Cormac Breen, Dimitrios-Anestis Moutzouris

Publikováno v: Kidney International Reports, Vol 5, Iss 7, Pp 1090-1094 (2020)

Externí odkaz: https://doaj.org/article/1ae1fe08c34a4bf49743efe5f63fd110

A double-blind randomised controlled investigation into the efficacy of Mirococept (APT070) for preventing ischaemia reperfusion injury in the kidney allograft (EMPIRIKAL): study protocol for a randomised controlled trial

Autor: Theodoros Kassimatis, Anass Qasem, Abdel Douiri, Elizabeth G. Ryan, Irene Rebollo-Mesa, Laura L. Nichols, Roseanna Greenlaw, Jonathon Olsburgh, Richard A. Smith, Steven H. Sacks, Martin Drage

Publikováno v: Trials, Vol 18, Iss 1, Pp 1-11 (2017)

Abstract Background Delayed graft function (DGF) is traditionally defined as the requirement for dialysis during the first week after transplantation. DGF is a common complication of renal transplantation, and it negatively affects short- and long-te

Externí odkaz: https://doaj.org/article/95f1aadf516d4e4bad73ce15ddf5811b

Ex vivo delivery of Mirococept: A dose-finding study in pig kidney after showing a low dose is insufficient to reduce delayed graft function in human kidney

Autor: Jonathon Olsburgh, Abdel Douiri, Guilherme Danzi, Anass Qasem, Richard A. G. Smith, Theodoros Kassimatis, Clare Flach, Peter J. Friend, Flavia Neri, Steven H. Sacks, James P. Hunter, Laura L. Nichols, Catherine Horsfield, Roseanna Greenlaw, Martin Drage, Irene Rebollo-Mesa, Julieta Karegli

Publikováno v: American Journal of Transplantation. 21:1012-1026

The complement system plays a pivotal role in the pathogenesis of ischemia-reperfusion injury in solid organ transplantation. Mirococept is a potent membrane-localizing complement inhibitor that can be administered ex vivo to the donor kidney prior t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc0e402a35a421659f29b3e00ca62f50
https://doi.org/10.1111/ajt.16265

Development of a multivariable gene-expression signature targeting T-cell-mediated rejection in peripheral blood of kidney transplant recipients validated in cross-sectional and longitudinal samples

Autor: Steven H. Sacks, Clara Domingo-Vila, Terry B. Strom, Florence Delaney, Claire Duff, Manohursingh Runglall, Paula Mobillo, Tjir Li Tsui, Rosa Montero, Sui Phin-Kon, Maria P. Hernandez-Fuentes, Yogesh Kamra, Anastasia Spiridou, Paramit Chowdhury, Graham M. Lord, Irene Rebollo-Mesa, Sofia Christakoudi, Daniel Stahl, Theodoros Kassimatis, Christopher K.T. Farmer, Beatriz Tucker

Publikováno v: EBioMedicine
EBioMedicine, Vol 41, Iss, Pp 571-583 (2019)
Christakoudi, S, Runglall, M, Mobillo, P, Tsui, T L, Duff, C, Domingo-Vila, C, Kamra, Y, Delaney, F, Montero, R, Spiridou, A, Kassimatis, T, Phin-Kon, S, Tucker, B, Farmer, C, Strom, T B, Lord, G M, Rebollo-Mesa, I, Stahl, D, Sacks, S, Hernandez-Fuentes, M P & Chowdhury, P 2019, ' Development of a multivariable gene-expression signature targeting T-cell-mediated rejection in peripheral blood of kidney transplant recipients validated in cross-sectional and longitudinal samples ', EBioMedicine, vol. 41, pp. 571-583 . https://doi.org/10.1016/j.ebiom.2019.01.060
Christakoudi, S, Runglall, M, Mobillo, P A, Tsui, T-L, Duff, C, Domingo Vila, C, Kamra, Y K, Delaney, F, Montero, R, Spiridou, A, Kassimatis, T, Phin Kon, S, Tucker, B, Farmer, C, Strom, T B, Lord, G M, Rebollo-Mesa, I, Stahl, D, Sacks, S, Hernandez-Fuentes, M P & Chowdhury, P 2019, ' Development of a multivariable geneexpression signature targeting T-cell-mediated rejection in peripheral blood of kidney transplant recipients validated in crosssectional and longitudinal samples ', EBioMedicine, vol. 41, no. 0, pp. 571-583 . https://doi.org/10.1016/j.ebiom.2019.01.060

Background Acute T-cell mediated rejection (TCMR) is usually indicated by alteration in serum-creatinine measurements when considerable transplant damage has already occurred. There is, therefore, a need for non-invasive early detection of immune sig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae24299bfbd3674285318dfe252d4a2a
http://europepmc.org/articles/PMC6441872

Delivering Dialysis During the COVID-19 Outbreak: Strategies and Outcomes

Autor: Theodoros Kassimatis, Tayeba Roper, Vicki Moxham, Cormac Breen, Dimitrios Anestis Moutzouris, Nicola Kumar, David Game, Timothy Lewis-Morris

Publikováno v: Kidney International Reports
Kidney International Reports, Vol 5, Iss 7, Pp 1090-1094 (2020)

Background Haemodialysis (HD) patients are at increased risk of COVID-19 infection. Although all dialysis patients meet government criteria for shielding, only those on home treatment can comply. Patients attending incentre HD units represent a large

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c819f2e0a0393eb371d0c91557148fd2