Zobrazeno 1 - 10
of 182
pro vyhledávání: '"Theodore S Jardetzky"'
Autor:
Xiaolin Wen, Jennifer Pickens, Jarrod J Mousa, George P Leser, Robert A Lamb, James E Crowe, Theodore S Jardetzky
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0155917 (2016)
Respiratory syncytial virus (RSV) and human metapneumovirus (HMPV) are paramyxoviruses that are responsible for substantial human health burden, particularly in children and the elderly. The fusion (F) glycoproteins are major targets of the neutraliz
Externí odkaz:
https://doaj.org/article/ba23e9b4714b43c39ae465a6528943d2
Autor:
Karthik Sathiyamoorthy, Jiansen Jiang, Yao Xiong Hu, Cynthia L Rowe, Britta S Möhl, Jia Chen, Wei Jiang, Elizabeth D Mellins, Richard Longnecker, Z Hong Zhou, Theodore S Jardetzky
Publikováno v:
PLoS Pathogens, Vol 10, Iss 8, p e1004309 (2014)
Epstein-Barr Virus (EBV) is an enveloped double-stranded DNA virus of the gammaherpesvirinae sub-family that predominantly infects humans through epithelial cells and B cells. Three EBV glycoproteins, gH, gL and gp42, form a complex that targets EBV
Externí odkaz:
https://doaj.org/article/8b7acd2542c642678bab7e0320cf2d9c
Autor:
Brett D Welch, Ping Yuan, Sayantan Bose, Christopher A Kors, Robert A Lamb, Theodore S Jardetzky
Publikováno v:
PLoS Pathogens, Vol 9, Iss 8, p e1003534 (2013)
Paramyxoviruses cause a wide variety of human and animal diseases. They infect host cells using the coordinated action of two surface glycoproteins, the receptor binding protein (HN, H, or G) and the fusion protein (F). HN binds sialic acid on host c
Externí odkaz:
https://doaj.org/article/e87e7976be5348d0822e0bff98c7121f
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e58874 (2013)
Incorporation of unnatural amino acids and peptidomimetic residues into therapeutic peptides is highly efficacious and commonly employed, but generally requires laborious trial-and-error approaches. Previously, we demonstrated that C20 peptide has th
Externí odkaz:
https://doaj.org/article/4bc3abc6f10e4c7d903bea5bdb4a19bf
Publikováno v:
PLoS Pathogens, Vol 8, Iss 8, p e1002855 (2012)
Paramyxovirus hemagglutinin-neuraminidase (HN) plays roles in viral entry and maturation, including binding to sialic acid receptors, activation of the F protein to drive membrane fusion, and enabling virion release during virus budding. HN can there
Externí odkaz:
https://doaj.org/article/639ea6861fad4b088f2546725cd2f43f
Autor:
Jie Zhu, Edward L Braun, Satomi Kohno, Monica Antenos, Eugene Y Xu, Robert W Cook, S Jack Lin, Brandon C Moore, Louis J Guillette, Theodore S Jardetzky, Teresa K Woodruff
Publikováno v:
PLoS ONE, Vol 5, Iss 3, p e9457 (2010)
Transforming growth factor-beta (TGFbeta) homologues form a diverse superfamily that arose early in animal evolution and control cellular function through membrane-spanning, conserved serine-threonine kinases (RII and RI receptors). Activin and inhib
Externí odkaz:
https://doaj.org/article/f0670ba69dc94e9c92be3ba9b0b9b9bd
Autor:
Luke F. Pennington, Pascal Gasser, Silke Kleinboelting, Chensong Zhang, Georgios Skiniotis, Alexander Eggel, Theodore S. Jardetzky
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Facilitated dissociation is a mechanism where antibody-mediated disruption of high-affinity complexes can enhance the therapeutic effects of a drug. Here the authors present a yeast display approach to select and engineer omalizumab variants that dis
Externí odkaz:
https://doaj.org/article/ce93054282b0409585dfb3dd0b17d1d1
Autor:
Evaristus C. Mbanefo, Loc Le, Luke F. Pennington, Yi- Ju Hsieh, Justin I. Odegaard, Kristina Lapira, Theodore S. Jardetzky, Franco H. Falcone, Michael H. Hsieh
Publikováno v:
Parasites & Vectors, Vol 13, Iss 1, Pp 1-11 (2020)
Abstract Background Parasitic infections can increase susceptibility to bacterial co-infections. This may be true for urogenital schistosomiasis and bacterial urinary tract co-infections (UTI). We previously reported that this co-infection is facilit
Externí odkaz:
https://doaj.org/article/57db53dd11c442ff85e265dc6750f3c5
Autor:
Pascal Gasser, Svetlana S. Tarchevskaya, Pascal Guntern, Daniel Brigger, Rahel Ruppli, Noemi Zbären, Silke Kleinboelting, Christoph Heusser, Theodore S. Jardetzky, Alexander Eggel
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Immunoglobulin E (IgE) plays a central role in allergic responses, yet therapeutic targeting of IgE with antibodies such as omalizumab is met with various limitations. Here the authors characterize the molecular properties and crystal structure of a
Externí odkaz:
https://doaj.org/article/e445acdbe9e24d959b171d05c7983a61
Publikováno v:
mBio, Vol 12, Iss 5 (2021)
HCMV is a herpesvirus that infects a large percentage of the adult population and causes significant levels of disease in immunocompromised individuals and birth defects in the developing fetus. The virus encodes a complex protein machinery that coor
Externí odkaz:
https://doaj.org/article/99a3ab6028954f238a25604e90e9a233