Zobrazeno 1 - 10
of 187
pro vyhledávání: '"Theodore R. Cummins"'
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 17 (2024)
IntroductionResurgent current (INaR) generated by voltage-gated sodium channels (VGSCs) plays an essential role in maintaining high-frequency firing of many neurons and contributes to disease pathophysiology such as epilepsy and painful disorders. Ta
Externí odkaz:
https://doaj.org/article/2c80377f9ae84466b6ea9bc4ae910d16
Autor:
Kiran George, Diego Lopez-Mateos, Tarek Mohamed Abd El-Aziz, Yucheng Xiao, Jake Kline, Hong Bao, Syed Raza, James D. Stockand, Theodore R. Cummins, Luca Fornelli, Matthew P. Rowe, Vladimir Yarov-Yarovoy, Ashlee H. Rowe
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Voltage-gated sodium channel NaV1.8 regulates transmission of pain signals to the brain. While NaV1.8 has the potential to serve as a drug target, the molecular mechanisms that shape NaV1.8 gating are not completely understood, particularly mechanism
Externí odkaz:
https://doaj.org/article/0dc9b79a83a742afa9602e8aab884a62
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Approximately 30% of patients with epilepsy do not achieve adequate seizure control through current anti-seizure drugs and treatment methods. Therefore, a critical need exists to efficiently screen anti-seizure drugs to enhance our ability to tailor
Externí odkaz:
https://doaj.org/article/9216de572c1542db94c9b44f1b25a93e
Autor:
Kirstin B. VanderWall, Ridhima Vij, Sarah K. Ohlemacher, Akshayalakshmi Sridhar, Clarisse M. Fligor, Elyse M. Feder, Michael C. Edler, Anthony J. Baucum, II, Theodore R. Cummins, Jason S. Meyer
Publikováno v:
Stem Cell Reports, Vol 12, Iss 2, Pp 201-212 (2019)
Summary: Retinal ganglion cells (RGCs) form the connection between the eye and the brain, with this connectivity disrupted in numerous blinding disorders. Previous studies have demonstrated the ability to derive RGCs from human pluripotent stem cells
Externí odkaz:
https://doaj.org/article/32b7f9cd1ac54eed97d9fd2c68d2ebbd
Publikováno v:
Cells, Vol 11, Iss 13, p 2108 (2022)
Aberrant Nav1.6 activity can induce hyperexcitability associated with epilepsy. Gain-of-function mutations in the SCN8A gene encoding Nav1.6 are linked to epilepsy development; however, the molecular mechanisms mediating these changes are remarkably
Externí odkaz:
https://doaj.org/article/ad1b378b4c7e4866806619807bdb5162
Autor:
Tarek Mohamed Abd El-Aziz, Yucheng Xiao, Jake Kline, Harold Gridley, Alyse Heaston, Klaus D. Linse, Micaiah J. Ward, Darin R. Rokyta, James D. Stockand, Theodore R. Cummins, Luca Fornelli, Ashlee H. Rowe
Publikováno v:
Toxins, Vol 13, Iss 7, p 501 (2021)
The voltage-gated sodium channel Nav1.8 is linked to neuropathic and inflammatory pain, highlighting the potential to serve as a drug target. However, the biophysical mechanisms that regulate Nav1.8 activation and inactivation gating are not complete
Externí odkaz:
https://doaj.org/article/66078cee5d4c41428eff491c6e30d661
Publikováno v:
Cells, Vol 10, Iss 7, p 1595 (2021)
Voltage-gated sodium channels (Navs) are critical determinants of cellular excitability. These ion channels exist as large heteromultimeric structures and their activity is tightly controlled. In neurons, the isoform Nav1.6 is highly enriched at the
Externí odkaz:
https://doaj.org/article/25a75908716041d29398ec9d79fd8a9b
Autor:
Ruchi Bansal, Staci E. Engle, Patrick J. Antonellis, Logan S. Whitehouse, Anthony J. Baucum, Theodore R. Cummins, Jeremy F. Reiter, Nicolas F. Berbari
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
Primary cilia dysfunction has been associated with hyperphagia and obesity in both ciliopathy patients and mouse models of cilia perturbation. Neurons throughout the brain possess these solitary cellular appendages, including in the feeding centers o
Externí odkaz:
https://doaj.org/article/9b25369212b44d63bbaada888fbf027e
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Cardiac voltage-gated sodium channels (Nav1.5) are crucial regulators of heart electric activity. Here the authors show that palmitoylation, a process of lipid modification of cysteine residues, modulates Nav1.5 function and affects cardiomyocyte exc
Externí odkaz:
https://doaj.org/article/ab603083dedd44c1938573e6d1f39389
Autor:
Emily R. Mason, Theodore R. Cummins
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 7, p 2454 (2020)
Many epilepsy patients are refractory to conventional antiepileptic drugs. Resurgent and persistent currents can be enhanced by epilepsy mutations in the Nav1.2 channel, but conventional antiepileptic drugs inhibit normal transient currents through t
Externí odkaz:
https://doaj.org/article/af9c9c3ea16f40d8bc1285684e0571fd