Maturation of West Nile virus modulates sensitivity to antibody-mediated neutralization.

Autor: Steevenson Nelson, Christiane A Jost, Qinq Xu, Jessica Ess, Julie E Martin, Theodore Oliphant, Stephen S Whitehead, Anna P Durbin, Barney S Graham, Michael S Diamond, Theodore C Pierson

Publikováno v: PLoS Pathogens, Vol 4, Iss 5, p e1000060 (2008)

West Nile virions incorporate 180 envelope (E) proteins that orchestrate the process of virus entry and are the primary target of neutralizing antibodies. The E proteins of newly synthesized West Nile virus (WNV) are organized into trimeric spikes co

Externí odkaz: https://doaj.org/article/96d0e3a92f414f39a003f8d5e50eb00a

Development of Resistance to Passive Therapy with a Potently Neutralizing Humanized Monoclonal Antibody against West Nile Virus

Autor: Matthew R. Vogt, Michael Engle, David W.C. Beasley, Michael S. Diamond, Shuliu Zhang, Evgeniy I. Bovshik, Theodore Oliphant

Publikováno v: The Journal of Infectious Diseases. 200:202-205

Previous studies have established the therapeutic efficacy of humanized E16 (hE16) monoclonal antibody against West Nile virus in animals. Here, we assess the potential for West Nile virus strains encoding mutations in the hE16 epitope to resist pass

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f6e48555465e72776f87ec1ee3acf904
https://doi.org/10.1086/599794

Type- and Subcomplex-Specific Neutralizing Antibodies against Domain III of Dengue Virus Type 2 Envelope Protein Recognize Adjacent Epitopes

Autor: Gregory D. Gromowski, Alan D.T. Barrett, Daved H. Fremont, Grant E. Nybakken, S. Kyle Austin, Theodore Oliphant, Whitney E. Purtha, John T. Roehrig, Michael S. Diamond, Soila Sukupolvi-Petty, Jacob J. Schlesinger

Publikováno v: Journal of Virology. 81:12816-12826

Neutralization of flaviviruses in vivo correlates with the development of an antibody response against the viral envelope (E) protein. Previous studies demonstrated that monoclonal antibodies (MAbs) against an epitope on the lateral ridge of domain I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f22cd0a95894fd8f2fa712a960f22b8
https://doi.org/10.1128/jvi.00432-07

The Stoichiometry of Antibody-Mediated Neutralization and Enhancement of West Nile Virus Infection

Autor: Michael S. Diamond, Steevenson Nelson, Theodore C. Pierson, Grant E. Nybakken, Qing Xu, Daved H. Fremont, Theodore Oliphant

Publikováno v: Cell Host & Microbe. 1(2):135-145

SummaryAntibody binding to the icosahedral arrangement of envelope proteins on the surface of flaviviruses can result in neutralization or enhancement of infection. We evaluated how many antibodies must bind to a given epitope on West Nile virus (WNV

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bcc7987672d530e965fd077258f8071

Longitudinal Population Analysis of Dual Infection with Recombination in Two Strains of HIV Type 1 Subtype B in an Individual from a Phase 3 HIV Vaccine Efficacy Trial

Autor: Jonathan Fuchs, Andrew Rambaut, Vivian T. Nguyen, David V. Jobes, Allan Padua, Theodore Oliphant, Phillip W. Berman, Marcos Pérez-Losada, David Posada, Faruk Sinangil, Melissa Daoust, Keith A. Crandall

Publikováno v: Jobes, D V, Daoust, M, Nguyen, V T, Padua, A, Sinangil, F, Perez-Losada, M, Crandall, K A, Oliphant, T, Posada, D, Rambaut, A, Fuchs, J & Berman, P W 2006, ' Longitudinal population analysis of dual infection with recombination in two strains of HIV type 1 subtype B in an individual from a phase 3 HIV vaccine efficacy trial ', Aids research and human retroviruses, vol. 22, no. 10, pp. 968-978 .

This study documents a case of coinfection (simultaneous infection of an individual with two or more strains) of two HIV-1 subtype B strains in an individual from a Phase 3 HIV-1 vaccine efficacy trial, conducted in North American and the Netherlands

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a77cb7bc05ef75d7d290052d6b90c48
https://doi.org/10.1089/aid.2006.22.968