Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Theodore N. Mellin"'
Autor:
Xiao-Ming Guan, Charles Rosenblum, Hong Yu, Yue Feng, D. Euan MacIntyre, Alison M. Strack, Lex H.T. Van der Ploeg, Christian N. Nunes, Airu S. Chen, Joseph M. Metzger, Linhai Cao, Easter G. Frazier, Jill K. Fisher, Ramon E. Camacho, William Min, Shobhna Gopal-Truter, Aurawan Vongs, Howard Y. Chen, Theodore N. Mellin, Donald J. Marsh, Myrna E. Trumbauer
Publikováno v:
Nature Genetics. 26:97-102
Genetic and pharmacological studies have defined a role for the melanocortin-4 receptor (Mc4r) in the regulation of energy homeostasis. The physiological function of Mc3r, a melanocortin receptor expressed at high levels in the hypothalamus, has rema
Autor:
Beth Ann Murphy, John Ronan, Theodore N. Mellin, Anna-Marie Fairhurst, M. Hanaway, Christian N. Nunes
Publikováno v:
Europe PubMed Central
MTII, an agonist of melanocortinergic receptors, is a well-documented anorexigenic agent in rats. Many investigators have reported its effects on feeding without considering concurrent alterations in other behaviors. Accordingly, we performed studies
Autor:
Donald J. Marsh, D. E. Macintyre, Xiao-Ming Guan, Michael J. Forrest, Easter G. Frazier, Airu S. Chen, Theodore N. Mellin, Ramon E. Camacho, Hong Yu, Jill K. Fisher, Van der Ploeg Lh, Joe Metzger, Alison M. Strack, Myrna E. Trumbauer, Howard Y. Chen, Shobhna Gopal-Truter
Publikováno v:
Transgenic Research. 9:145-154
We evaluated the role of the melanocortin-4 receptor (MC-4R) in the control of metabolic rate and food intake in mice. Intraperitoneal administration of the non-selective MC-R agonist melanotan II (MT-II; a cyclic heptapeptide) increases metabolic ra
Autor:
L. H. T. Van Der Ploeg, Christian N. Nunes, John Ronan, M. Hanaway, Anna-Marie Fairhurst, D.E Maclntyre, C.M Harper, Beth Ann Murphy, Theodore N. Mellin, M.J Beall
Publikováno v:
Neuropeptides. 32:491-497
Melanocortinergic neurons are believed to play a role in the control of food intake. Melanocortin receptor agonists and antagonists modulate feeding in several mouse models of chemically and genetically induced hyperphagia. To date, little informatio
Autor:
Jeffrey P Varnerin, T. Smith, Aurawan Vongs, Patricia J. Hey, M. Chou, Joseph J. King, Theodore N. Mellin, Easter G. Frazier, Michael R. Tota, D. E. Macintyre, Beth Junker, Beth Ann Murphy, Charles Rosenblum, Christian N. Nunes, B. W. Burgess, L. H. T. Van Der Ploeg
Publikováno v:
Protein Expression and Purification. 14:335-342
A procedure is described for gram-scale refolding of Escherichia coli-derived human leptin inclusion bodies. Refolding was achieved by gradually reducing denaturant using a diafiltration method. Refolded leptin is characterized by in vivo modulation
Autor:
Maciej Dryjski, John Tluczek, Thorir D. Bjornsson, John Ronan, Kenneth A. Thomas, Theodore N. Mellin, Robert Mennie
Publikováno v:
Proceedings of the National Academy of Sciences. 88:8651-8655
Intravascular injury to arteries can result in thickening of the intimal smooth muscle layer adjacent to the lumen by migration and proliferation of cells from the underlying medial smooth muscle layer accompanied by deposition of extracellular matri
Autor:
Klaus D. Schleim, Doreen E. Cashen, Susan P. Rohrer, James M. Schaeffer, Khaled Barakat, Ravi P. Nargund, Elizabeth T. Birzin, Thomas M. Jacks, Gerard J. Hickey, Theodore N. Mellin, Arthur A. Patchett, Ralph T. Mosley
Publikováno v:
Peptides for the New Millennium ISBN: 0792364457
Selective human somatostatin subtype-2 (hsst2) receptor agonists have received considerable attention recently since they may offer benefit in treating diabetes [1]. Specifically, sst2 activation inhibits growth hormone (GH) and glucagon release with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e0c86f33aba114b347b353db444df9d5
https://doi.org/10.1007/0-306-46881-6_100
https://doi.org/10.1007/0-306-46881-6_100
Autor:
Zhizhen Zeng, Christopher P. Austin, David L. Williams, Sheng-Shung Pong, Kevin R. Lynch, C. Thomas Caskey, Xiao-Ming Guan, Andrew D. Howard, Jilly F. Evans, Scott D. Feighner, Terrence P. McDonald, Beth Ann Murphy, Qingyun Liu, Ruiping Wang, Alison M. Strack, Judith N. Stair, Theodore N. Mellin, Karen K. McKee, Carina P. Tan, Qingping Jiang, Lex H.T. Van der Ploeg, Michelle K. Clements, Christian N. Nunes, Hong Yu, Donna L. Hreniuk
Publikováno v:
Nature. 406(6791)
Neuromedin U (NMU) is a neuropeptide with potent activity on smooth muscle which was isolated first from porcine spinal cord and later from other species. It is widely distributed in the gut and central nervous system. Peripheral activities of NMU in
Publikováno v:
The Journal of steroid biochemistry and molecular biology. 44(2)
Elevated levels of testosterone 5 alpha-reductase (5 alpha-R) and its product, dihydrotestosterone are associated with a number of androgen-dependent skin conditions. A series of 4-azasteroids were tested in vitro as inhibitors of 5 alpha-R in the is
Autor:
Theodore N. Mellin, Robert J. Mennie, Doreen E. Cashen, John J. Ronan, Joanna Capparella, Mary Lou James, Jerry Disalvo, John Frank, David Linemeyer, Guillermo Gimenez-Gallego, Kenneth A. Thomas
Publikováno v:
Growth factors (Chur, Switzerland). 7(1)
Acidic fibroblast growth factor (aFGF) is a potent mitogen in vitro for many cells of ectodermal and mesodermal embryonic origin including skin-derived epidermal keratinocytes, dermal fibroblasts and vascular endothelial cells. Based on the mitogenic